Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes

Autor: Janey L. Wiggs, C.M. vanDuijn, Vincent Laville, Adriana I Iglesias, Daniel I. Chasman, Bernard Rosner, Jessica N. Cooke Bailey, James F. Wilson, Michael A. Hauser, Jae H. Kang, William G. Christen, Christopher J Hammond, Hugues Aschard, Puya Gharahkhani, John H. Fingert, Alex W. Hewitt, Stuart MacGregor, Frank B. Hu, Peter Kraft, Louis R. Pasquale, Robert P. Igo, Yeunjoo E. Song, David A. Mackey, Pirro G. Hysi, Jonathan L. Haines, UK Biobank, Anthony P Khawaja, Clara C. Cousins, Reka Nagy, Veronique Vitart

Publikováno v: American Journal of Ophthalmology
American Journal of Ophthalmology, Elsevier Masson, 2019, 206, pp.245-255. ⟨10.1016/j.ajo.2019.05.015⟩
American Journal of Ophthalmology, 2019, 206, pp.245-255. ⟨10.1016/j.ajo.2019.05.015⟩
American Journal of Ophthalmology, 206, 245-255. Elsevier Inc.
Am J Ophthalmol
Laville, V, Kang, J H, Cousins, C, Iglesias, A I, Nagy, R, Cooke Bailey, J N, Igo, R P, Song, Y E, Chasman, D I, Christen, W, Kraft, P & Wilson, J F & Vitart, V 2019, ' Genetic correlations between diabetes and glaucoma: an analysis of continuous and dichotomous phenotypes ', American journal of ophthalmology . https://doi.org/10.1016/j.ajo.2019.05.015

Purpose A genetic correlation is the proportion of phenotypic variance between traits that is shared on a genetic basis. Here we explore genetic correlations between diabetes- and glaucoma-related traits. Design Cross-sectional study. Methods We asse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37eb2ae4c5d9cebd21d3aa695a2b922
https://hal-pasteur.archives-ouvertes.fr/pasteur-03278624

Mutation profile of glaucoma candidate genes in Mauritanian families with primary congenital glaucoma

Autor: Hadrami, Mouna, Bonnet, Crystel, Zeitz, Christina, Veten, Fatimetou, Biya, Med, Hamed, Cheikh T., Condroyer, Christel, Wang, Panfeng, Sidi, Med Mahmoud, Cheikh, Sidi, Qingjiong Zhang, Audo, Isabelle, Petit, Christine, Houmeida, Ahmed

Publikováno v: Molecular Vision
Molecular Vision, Molecular Vision, 2021, 25, pp.373-381
Molecular Vision, 2021, 25, pp.373-381
Web of Science

International audience; Purpose: Intraocular pressure leading to glaucoma is a major cause of childhood blindness in developing countries. In this study, we sought to identify gene variants potentially associated with primary congenital glaucoma (PCG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed03b001ad201eddf89b14cb473c8b38
https://pubmed.ncbi.nlm.nih.gov/31367175

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

Autor: Pasquale, Louis, Aschard, Hugues, Kang, Jae, Bailey, Jessica, Lindström, Sara, Chasman, Daniel, Christen, William, Allingham, R Rand, Ashley-Koch, Allison, Lee, Richard, Moroi, Sayoko, Brilliant, Murray, Wollstein, Gadi, Schuman, Joel, Fingert, John, Budenz, Donald, Realini, Tony, Gaasterland, Terry, Gaasterland, Douglas, Scott, William, Singh, Kuldev, Sit, Arthur, Igo, Robert, Song, Yeunjoo, Hark, Lisa, Ritch, Robert, Rhee, Douglas, Gulati, Vikas, Havens, Shane, Vollrath, Douglas, Zack, Donald, Medeiros, Felipe, Weinreb, Robert, Pericak-Vance, Margaret, Liu, Yutao, Kraft, Peter, Richards, Julia, Rosner, Bernard, Hauser, Michael, Haines, Jonathan, Wiggs, Janey, Allingham, R. Rand

Publikováno v: Menopause
Menopause, Lippincott, Williams & Wilkins, 2017, 24 (2), pp.150-156. ⟨10.1097/GME.0000000000000741⟩
Menopause (New York, N.Y.), vol 24, iss 2
Menopause (New York, N.y.)

Supplemental Digital Content is available in the text
Objective: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88080e30449fd5ce3a8f23c07d0c8316
https://hal-pasteur.archives-ouvertes.fr/pasteur-03278728

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Autor: Qibin Qi, Shamira A. Perera, Bernd Wissinger, Paul Mitchell, Christopher J Hammond, Janey L. Wiggs, Frank B. Hu, Donald J. Zack, Murray H. Brilliant, Ching-Yu Cheng, Paul M. Ridker, Pirro G. Hysi, Brian L. Yaspan, Tony Realini, Margaret A. Pericak-Vance, Fotis Topouzis, Eranga N. Vithana, Jessica N. Cooke Bailey, Andrew A. Brown, Gadi Wollstein, Robert N. Weinreb, Jie Jin Wang, Chiea Chuen Khor, Stephanie Loomis, Puya Gharahkhani, David J. Hunter, Stuart MacGregor, Robert Ritch, Hyon K. Choi, Paul R. Lichter, William G. Christen, Hugues Aschard, Yutao Liu, R. Rand Allingham, Douglas E. Gaasterland, Julia E. Richards, Ananth C. Viswanathan, Marylyn D. Ritchie, Eric B. Rimm, Louis R. Pasquale, Yeunjoo E. Song, Robert P. Igo, Shefali S. Verma, John H. Fingert, Kang Zhang, Gary C. Curhan, Paul J. Foster, Peter Kraft, Charles S. Fuchs, Michael A. Hauser, Immaculata De Vivo, Kathryn P. Burdon, Daniel I. Chasman, Kerrin S. Small, Keating W. Pepper, Kuldev Singh, Rulla M. Tamimi, Alfonso Buil, Peter McGuffin, Alex W. Hewitt, Sayoko E. Moroi, Donald L. Budenz, Richard K. Lee, Nicole Weisschuh, Arthur J. Sit, David A. Mackey, Anthony P Khawaja, William K. Scott, Joel S. Schuman, Terry Gaasterland, Douglas Vollrath, Tien Yin Wong, Craig A. Glastonbury, Zheng Li, Allison E. Ashley-Koch, Jae H. Kang, Jamie E Craig, Jonathan L. Haines, Tin Aung, Gareth R. Howell

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2016, 48 (2), pp.189-194. ⟨10.1038/ng.3482⟩
Nature genetics

International audience; Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from eight independent studies from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea58750950c32ae326ace8b1d0e5a44e
https://hal-pasteur.archives-ouvertes.fr/pasteur-03278582

CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension

Autor: William Rostène, Julie Frugier, Françoise Baleux, David Godefroy, Isabelle Célérier, Serge Picaud, Françoise Brignole-Baudouin, Julie Degardin, Jeffrey K. Harrison, Christophe Baudouin, José Sahel, Alexandre Denoyer

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e37873. ⟨10.1371/journal.pone.0037873⟩
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e37873. 〈10.1371/journal.pone.0037873〉
PLoS ONE, Vol 7, Iss 6, p e37873 (2012)
PLoS ONE, 2012, 7 (6), pp.e37873. ⟨10.1371/journal.pone.0037873⟩

International audience; Glaucoma, the most common cause of irreversible blindness, is a neuropathy commonly initiated by pathological ocular hypertension due to unknown mechanisms of trabecular meshwork degeneration. Current antiglaucoma therapy does

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f2117383dc58fb64ab823fe3a14537
https://pubmed.ncbi.nlm.nih.gov/22675496