Zobrazeno 1 - 10
of 129
pro vyhledávání: '"MESH : Genome-Wide Association Study"'
Autor:
Qing Li, Jieyi Chen, Pierre Faux, Miguel Eduardo Delgado, Betty Bonfante, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, J. Camilo Chacón-Duque, Malena Hurtado, Valeria Villegas, Vanessa Granja, Claudia Jaramillo, William Arias, Rodrigo Barquera, Paola Everardo-Martínez, Mirsha Sánchez-Quinto, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Tábita Hünemeier, Virginia Ramallo, Sijie Wu, Siyuan Du, Andrea Giardina, Soumya Subhra Paria, Mahfuzur Rahman Khokan, Rolando Gonzalez-José, Lavinia Schüler-Faccini, Maria-Cátira Bortolini, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Winston Rojas, Francisco Rothhammer, Nicolas Navarro, Sijia Wang, Kaustubh Adhikari, Andrés Ruiz-Linares
Publikováno v:
Communications Biology
Communications Biology, 2023, 6 (1), pp.481. ⟨10.1038/s42003-023-04838-7⟩
Research Square
Communications Biology, 2023, 6 (1), pp.481. ⟨10.1038/s42003-023-04838-7⟩
Research Square
e report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value
Autor:
Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Élise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Publikováno v:
European Urology
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
Background: Genetic factors play an important role in prostate cancer (PCa) susceptibility.Objective: To discover common genetic variants contributing to the risk of PCa in men of African ancestry.Design, setting, and participants: We conducted a met
Publikováno v:
Bioinformatics
Bioinformatics, 2022, 38 (24), pp.5443-5445. ⟨10.1093/bioinformatics/btac689⟩
Bioinformatics, 2022, 38 (24), pp.5443-5445. ⟨10.1093/bioinformatics/btac689⟩
Summary Genome wide association studies elucidate links between genotypes and phenotypes. Recent studies point out the interest of conducting such experiments using k-mers as the base signal instead of single-nucleotide polymorphisms. We propose a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1c9de1911009d34c4e0ca5befee189
https://inria.hal.science/hal-03885124
https://inria.hal.science/hal-03885124
Autor:
Elizabeth T. Cirulli, Nicole L. Washington, Mickaël Canouil, Guillaume Charpentier, Emmanuelle Durand, Jean-Michel Borys, Alexandre Bolze, Franck De Graeve, Aurélie Dechaume, David Le Guilcher, Beverley Balkau, Sylvia Franc, Frédéric Allegaert, Ronan Roussel, Emmanuel Vaillant, Philippe Froguel, Gai Elhanan, Stefan Gaget, Joseph J. Grzymski, Loic Yengo, Véronique Dhennin, Amélie Bonnefond, James T. Lu, M Vaxillaire, Mathilde Boissel, Michel Marre, Bénédicte Toussaint
Publikováno v:
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
International audience; Genome-wide association studies have identified 240 independent loci associated with type 2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast, the genetic diagnosis of monogenic forms of
Autor:
Patrick Schmid, Enos Bernasconi, Ioannis Theodorou, Sophia S. Wang, Pejman Mohammadi, Paul J. McLaren, Huldrych F. Günthard, Matthias Cavassini, Charles S. Rabkin, Matthias Hoffmann, Christian Hammer, Shehnaz K. Hussain, Jacques Fellay, Andri Rauch, Cécile Goujard, Laurence Meyer, Jonathan Niay, Caroline Besson, Nava Ehsan, Tiphaine Oudot-Mellakh, Dominique Costagliola, Manuel Battegay, Christian W. Thorball, Federico Santoni
Publikováno v:
Haematologica
Haematologica, Ferrata Storti Foundation, 2021, 106 (8), pp.2233-2241. ⟨10.3324/haematol.2020.247023⟩
Haematologica, vol. 106, no. 8, pp. 2233-2241
Haematologica, Ferrata Storti Foundation, 2021, 106 (8), pp.2233-2241. ⟨10.3324/haematol.2020.247023⟩
Haematologica, vol. 106, no. 8, pp. 2233-2241
International audience; Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of develo
Autor:
Zuzanna Makowska, Ricard Cervera, Lorenzo Beretta, László Kovács, Marta E. Alarcón-Riquelme, Guillermo Barturen, Isabel Almeida, Divi Cornec, Javier Martín, Jacques-Olivier Pers, Ellen De Langhe, Nicolas Hunzelmann, Carlo Chizzolini, Maria Gerosa, Martin Kerick, Ralf Lesche, Chiara Bellocchi, Barbara Vigone, Rafaela Ortega Castro
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digital.CSIC. Repositorio Institucional del CSIC
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2020, 79 (9), pp.1218-1226. ⟨10.1136/annrheumdis-2020-217116⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digital.CSIC. Repositorio Institucional del CSIC
Objectives: The analysis of annotated transcripts from genome-wide expression studies may help to understand the pathogenesis of complex diseases, such as systemic sclerosis (SSc). We performed a whole blood (WB) transcriptome analysis on RNA collect
A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
Autor:
Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Christophe, Jamin, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valérie, Boudjeniba, Cheïma, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodríguez-Pintó, Ignasi, de Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovács, László, Witte, Torsten, Bettacchioli, Eléonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Borghi, Maria Orietta, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickaël, Moingeon, Philippe, Alarcón-Riquelme, Marta, Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabel, Gonzalez-Gay Mantecón, Miguel Angel, Blanco Alonso, Ricardo, Corrales Martínez, Alfonso, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Aguirre-Zamorano, Ma Angeles, Escudero-Contreras, Alejandro, Castro-Villegas, Ma Carmen, Jiménez Gómez, Yolanda, Ortego, Norberto, Fernández Roldán, María Concepción, Raya, Enrique, Jiménez Moleón, Inmaculada, de Ramon, Enrique, Díaz Quintero, Isabel, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Zuber, Aleksandra, Wynar, Donatienne, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Hiepe, Falk, Thiel, Silvia, Rodriguez Maresca, Manuel, López-Berrio, Antonio, Aguilar-Quesada, Rocío, Navarro-Linares, Héctor, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcón Riquelme, Marta, Gomes Anjos, Tania, Marañón, Concepción, Le Lann, Lucas, Simon, Quentin, Rouvière, Bénédicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Gerl, Velia, Khodadadi, Laleh, Cheng, Qingyu, de Groof, Aurélie, Ducreux, Julie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Neves, Esmeralda, Rao, Sambasiva, Jouve, Pierre-Emmanuel
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
Nature Communications, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
International audience; Abstract There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1398::61506dd34eed6fb273e9c83af11f3311
https://hal.univ-brest.fr/hal-03301637
https://hal.univ-brest.fr/hal-03301637
Autor:
Edwin K. Silverman, Justin Lee, Michael H. Cho, Iuliana Ionita-Laza, Chen Wang, Zihuai He, Wendy K. Chung, Joseph D. Buxbaum, Linxi Liu, Hugues Aschard, Richard Gill, James L. Dalgleish, Shiyang Ma
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2105191118. ⟨10.1073/pnas.2105191118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2105191118. ⟨10.1073/pnas.2105191118⟩
Significance Gene-based tests are important tools for elucidating the genetic basis of complex traits. Despite substantial recent efforts in this direction, the existing tests are still limited, owing to low power and detection of false-positive sign
Autor:
Julienne, Hanna, Laville, Vincent, Mccaw, Zachary, He, Zihuai, Guillemot, Vincent, Lasry, Carla, Ziyatdinov, Andrey, Nerin, Cyril, Vaysse, Amaury, Lechat, Pierre, Ménager, Hervé, Le Goff, Wilfried, Dube, Marie-Pierre, Kraft, Peter, Ionita-Laza, Iuliana, Vilhjálmsson, Bjarni, Aschard, Hugues
Publikováno v:
PLoS Genetics
Julienne, H, Laville, V, McCaw, Z R, He, Z, Guillemot, V, Lasry, C, Ziyatdinov, A, Nerin, C, Vaysse, A, Lechat, P, Ménager, H, Le Goff, W, Dube, M-P, Kraft, P, Ionita-Laza, I, Vilhjálmsson, B J & Aschard, H 2021, ' Multitrait GWAS to connect disease variants and biological mechanisms ', PLOS Genetics, vol. 17, no. 8, e1009713 . https://doi.org/10.1371/journal.pgen.1009713
PLoS Genetics, 2021, 17 (8), pp.e1009713. ⟨10.1371/journal.pgen.1009713⟩
PLoS Genetics, Vol 17, Iss 8, p e1009713 (2021)
Julienne, H, Laville, V, McCaw, Z R, He, Z, Guillemot, V, Lasry, C, Ziyatdinov, A, Nerin, C, Vaysse, A, Lechat, P, Ménager, H, Le Goff, W, Dube, M-P, Kraft, P, Ionita-Laza, I, Vilhjálmsson, B J & Aschard, H 2021, ' Multitrait GWAS to connect disease variants and biological mechanisms ', PLOS Genetics, vol. 17, no. 8, e1009713 . https://doi.org/10.1371/journal.pgen.1009713
PLoS Genetics, 2021, 17 (8), pp.e1009713. ⟨10.1371/journal.pgen.1009713⟩
PLoS Genetics, Vol 17, Iss 8, p e1009713 (2021)
Genome-wide association studies (GWASs) have uncovered a wealth of associations between common variants and human phenotypes. Here, we present an integrative analysis of GWAS summary statistics from 36 phenotypes to decipher multitrait genetic archit
Autor:
Astrid T. Groot, Brad S. Coates, David G. Heckel, Melanie Unbehend, Teun Dekker, Fotini Koutroumpa, Erik B. Dopman, Genevieve M. Kozak
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.2818. ⟨10.1038/s41467-021-23026-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2818. ⟨10.1038/s41467-021-23026-x⟩
Nature Communications, 12:2818. Nature Publishing Group
Nature Communications, 2021, 12 (1), pp.2818. ⟨10.1038/s41467-021-23026-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2818. ⟨10.1038/s41467-021-23026-x⟩
Nature Communications, 12:2818. Nature Publishing Group
The sex pheromone system of ~160,000 moth species acts as a powerful form of assortative mating whereby females attract conspecific males with a species-specific blend of volatile compounds. Understanding how female pheromone production and male pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f57cf501264c41a6dbad628ac10751
https://hal.sorbonne-universite.fr/hal-03250080
https://hal.sorbonne-universite.fr/hal-03250080