Výsledky vyhledávání - "MESH : Gene Expression Regulation, Neoplastic"

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

Autor: Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩

International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y

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Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer

Autor: Foucauld Chamming's, Thomas Guilbert, Virginie Mieulet, Elisabetta Marangoni, Anne Vincent-Salomon, Fatima Mechta-Grigoriou, Yann Kieffer, Fariba Nemati, Camille Garnier, Gilles Renault

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11 (1), pp.4219. ⟨10.1038/s41598-021-83685-0⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal molecular subtype (50% cases). These tumors show a desmoplastic reaction with accumu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebc6698c39c3864f71f7f005ae0bdd1
https://ut3-toulouseinp.hal.science/hal-03778944

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Phase II study evaluating the association of gemcitabine, trastuzumab and erlotinib as first‐line treatment in patients with metastatic pancreatic adenocarcinoma ( GATE 1)

Autor: Caroline Mollevi, Marc Ychou, Hélène de Forges, Fabienne Portales, Thomas Walter, Catherine Lombard-Bohas, Laurent Mineur, Emmanuelle Samalin, Thibaut Mazard, Eric Assenat, Marie Dupuy, Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Florence Boissière-Michot

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2021, 148 (3), pp.682-691. ⟨10.1002/ijc.33225⟩

International audience; In a previous phase II study (THERAPY), cetuximab and trastuzumab combination, as second-line after progression with gemcitabine, showed disease stabilization in 27% of 33 patients with pancreatic carcinoma. In the present pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d22e7a47f1fac4149eece0399f76367
https://hal.archives-ouvertes.fr/hal-03670041

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MicroRNAs Associated With a Good Prognosis of Acute Myeloid Leukemia and Their Effect on Macrophage Polarization

Autor: Alexandra Neaga, Cristina Bagacean, Adrian Tempescul, Laura Jimbu, Oana Mesaros, Cristina Blag, Ciprian Tomuleasa, Corina Bocsan, Mihaela Gaman, Mihnea Zdrenghea

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, 11, pp.582915. ⟨10.3389/fimmu.2020.582915⟩
Frontiers in Immunology, Vol 11 (2021)

International audience; Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with poor outcomes despite very intensive therapeutic approaches. For the majority of patients which are unfit and treated less intensively, the prognosis is eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d116c053505ae2ddbef303a40fb51
https://doi.org/10.3389/fimmu.2020.582915

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PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Publikováno v: Cancer Research
Cancer Research, 2021, 81 (11), pp.2888-2902. ⟨10.1158/0008-5472.CAN-21-0628⟩

Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell carcinomas (ccRCC). To identify novel therapeutic approaches to targeting PBRM1-defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::41b7210ec366a83600f22391bf78d19d
https://hal.science/hal-03447176/document

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Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells

Autor: Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-Panabières

Publikováno v: Cells
Cells, MDPI, 2020, 9 (8), pp.1836. ⟨10.3390/cells9081836⟩
Cells, Vol 9, Iss 1836, p 1836 (2020)

International audience; In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36907ba8ed03087936667735777f1185
https://hal.umontpellier.fr/hal-03367929

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Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nature Structural & Molecular Biology
Nature Structural and Molecular Biology, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nat Struct Mol Biol

International audience; The synthesis of poly(ADP-ribose) (PAR) reconfigures the local chromatin environment and recruits DNA-repair complexes to damaged chromatin. PAR degradation by poly(ADP-ribose) glycohydrolase (PARG) is essential for progressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d45f0c33f255ca7323659e74359498
https://hal.sorbonne-universite.fr/hal-03138406

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High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

Autor: Marie-Therese Haider, Laure Cayrefourcq, Nico Hinz, Klaus Pantel, Catherine Alix-Panabières, Daniel J Smit, Manfred Jücker

Publikováno v: Cells
Cells, MDPI, 2020, 9 (9), pp.2129. ⟨10.3390/cells9092129⟩
Volume 9
Issue 9
Cells, Vol 9, Iss 2129, p 2129 (2020)

International audience; Circulating tumor cells (CTCs) are cells shed from the primary tumor into the bloodstream. While many studies on solid tumor cells exist, data on CTCs are scarce. The mortality of cancer is mostly associated with metastasis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329e37a177f287f26f3e0379a18379f2
https://hal.umontpellier.fr/hal-03338498

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TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

Autor: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩

International audience; Abstract : Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efdc0696479c6db9b921256206c223
https://doi.org/10.1016/j.canlet.2018.08.027

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