Histone variant H2A.Z regulates zygotic genome activation

Autor: Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩

During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7911d2dde2a04081f895092d6c6f58d5
https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9

Biphasic (5-2%) oxygen concentration strategy significantly improves the usable blastocyst and cumulative live birth rates in in vitro fertilization

Autor: Tal Anahoryl, Chloé Baron, Samir Hamamah, Aneta Andreeva, Noemie Ranisavljevic, Fatima Barry, Alice Ferrieres-Hoa, Anna Gala, Delphine Haouzi, Sophie Brouillet, V. Loup, Laura Gaspari

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11 (1), pp.22461. ⟨10.1038/s41598-021-01782-6⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Oxygen (O2) concentration is approximately 5% in the fallopian tube and 2% in the uterus in humans. A “back to nature” approach could increase in vitro fertilization (IVF) outcomes. This hypothesis was tested in this monocentric observational ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73800897ada503a717257018ffc2ecd9
https://pubmed.ncbi.nlm.nih.gov/35534533

Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification

Autor: Hynek Wichterle, Virginie Rouiller-Fabre, Nour Nicolas, Gist F. Croft, Vincent Mouilleau, Vanessa Ribes, Léa Lesueur, Célia Vaslin, Mathieu Daynac, Stéphane Nedelec, Angélique Terray, Margot Jarrige, Simona Gribaudo, Mackenzie W. Mathis, Cécile Martinat, Rémi Robert

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2021, 148 (6), ⟨10.1242/dev.194514⟩
Development

Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether the pace of sequential activation of HOX genes, the 'HOX clock', is controlled by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e0481a9887cbd9be52c24e87935e7c
https://hal.science/hal-03550019

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

Autor: Gail E. Herman, Jennifer Reichert, Camilla Stoltenberg, Stephen Sanders, Menachem Fromer, Branko Aleksic, Julian Maller, Rachel Nguyen, Utku Norman, J. Jay Gargus, Donna M. Werling, David J. Cutler, Silvia De Rubeis, Kathryn Roeder, Ryan N. Doan, Sherif Gerges, Joseph D. Buxbaum, Per Magnus, Patrick Turley, Moyra Smith, Isaac N. Pessah, Rebecca J. Schmidt, Chiara Fallerini, Michael E. Talkowski, Carla Lintas, Pål Surén, Paige M. Siper, Duncan S. Palmer, Timothy W. Yu, Michael S. Breen, Sven Sandin, Esben Agerbo, Rich Belliveau, Antonio M. Persico, Elaine Cristina Zachi, Matthew W. State, Karoline Teufel, Margaret A. Pericak-Vance, Caitlin E. Carey, Ryan Collins, Lambertus Klei, Lara Tang, Mads V. Hollegaard, Ole Mors, Iuliana Ionita-Laza, Elisa Giorgio, Astanand Jugessur, Gerry Schellenberg, Christopher A. Walsh, A. Ercument Cicek, Caroline Dias, Gun Peggy Knudsen, Louise Gallagher, Elise B. Robinson, Abraham Reichenberg, Judith Miller, Ashley Dumont, Flora Tassone, Grace Schwartz, Peter Szatmari, Jacqueline I. Goldstein, Evelise Riberi, Brian H.Y. Chung, Stephen W. Scherer, Fátima Lopes, Jesslyn Jamison, Thomas Werge, Mara Parellada, Gabriela Soares, Hilary Coon, Shan Dong, Terho Lehtimäki, Norio Ozaki, Lauren A. Weiss, Susan L. Santangelo, F. Kyle Satterstrom, Daniel P. Howrigan, Emily Hansen-Kiss, Anders D. Børglum, Vivek Appadurai, Maria Rita Passos-Bueno, Hailiang Huang, Marcus C.Y. Chan, Eric M. Morrow, Stephen J. Guter, Catalina Betancur, Ditte Demontis, Matthew W. Mosconi, Pierandrea Muglia, Joanna Martin, Jack A. Kosmicki, Christine M. Freitag, Suma Jacob, W. Ian Lipkin, Angel Carracedo, Mark J. Daly, Andreas G. Chiocchetti, Eduarda Montenegro M. de Souza, Carsten Bøcker Pedersen, Isabela Maya Wahys Silva, Elizabeth E. Guerrero, Mafalda Barbosa, A. Jeremy Willsey, Maureen Mulhern, Claire Churchhouse, Raymond K. Walters, Timothy Poterba, Alessandra Renieri, Emilie M. Wigdor, Lauren M. Schmitt, Jennifer L. Moran, Mullin H.C. Yu, Edwin H. Cook, Jiebiao Wang, Behrang Mahjani, Kaitlin E. Samocha, Kaija Puura, Xin He, Ezra Susser, Aarno Palotie, Bernardo Dalla Bernardina, Montserrat Fernández-Prieto, Thomas Damm Als, Mykyta Artomov, Emma Wilkinson, Mads E. Hauberg, Enrico Domenici, Joon Yong An, Christine Søholm Hansen, Somer L. Bishop, Idan Menashe, So Lun Lee, Marianne Giørtz Pedersen, Alfredo Brusco, Nancy J. Minshew, Michael E. Zwick, Jesper Buchhave Poulsen, Elaine T. Lim, Benjamin M. Neale, Harrison Brand, Danielle Halpern, Elisabetta Trabetti, Alexander Kolevzon, Christine Stevens, Aurora Currò, Miia Kaartinen, Gal Meiri, Richard Anney, Søren Dalsgaard, Minshi Peng, Kimberly Chambert, Brooke Sheppard, Yunin Ludena, James S. Sutcliffe, Marie Bækvad-Hansen, Xinyi Xu, Audrey Thurm, Itaru Kushima, Michael Gill, Irva Hertz-Picciotto, Jonatan Pallesen, Stephan Ripke, Dara S. Manoach, Giovanni Battista Ferrero, Nell Maltman, Michael L. Cuccaro, David M. Hougaard, Javier González-Peñas, Wesley K. Thompson, Felecia Cerrato, Danielle de Paula Moreira, Jonas Bybjerg-Grauholm, Alicia R. Martin, Merete Nordentoft, John A. Sweeney, Alfonso Buil, Tarjinder Singh, Bernie Devlin, Jakob Grove, Daniel H. Geschwind, Manuel Mattheisen, Patrícia Maciel, Preben Bo Mortensen, Andrew J. Schork, Ryan Yuen, Christina M. Hultman, Maria del Pilar Trelles, Aparna Bhaduri, Sabine Schlitt, Diego Lopergolo

Publikováno v: Cell
Cell, Elsevier, 2020, 180 (3), pp.568-584.e23. ⟨10.1016/j.cell.2019.12.036⟩
Satterstrom, F K, Kosmicki, J A, Wang, J, Breen, M S, De Rubeis, S, An, J Y, Peng, M, Collins, R, Grove, J, Klei, L, Stevens, C, Reichert, J, Mulhern, M S, Artomov, M, Gerges, S, Sheppard, B, Xu, X, Bhaduri, A, Norman, U, Brand, H, Schwartz, G, Nguyen, R, Guerrero, E E, Dias, C, Autism Sequencing Consortium, iPSYCH-Broad Consortium & Børglum, A D 2020, ' Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism ', Cell, vol. 180, no. 3, pp. 568-584.e23 . https://doi.org/10.1016/j.cell.2019.12.036
Autism Sequencing Consortium & Mortensen, P B 2020, ' Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism ', Cell, vol. 180, no. 3, pp. 568-584.e23 . https://doi.org/10.1016/j.cell.2019.12.036
Cell, 2020, 180 (3), pp.568-584.e23. ⟨10.1016/j.cell.2019.12.036⟩

International audience; We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to integrate de novo and case-control rare variation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7b88cb815d29ba4171a1d3556d3c44
https://www.hal.inserm.fr/inserm-03135343

Postnatal Tshz3 deletion drives altered corticostriatal function and autism spectrum disorder-like behavior

Autor: Michèle Carlier, Pierre L. Roubertoux, Christina Frahm, Laurent Fasano, Mehdi Metwaly, Dany Severac, Paolo Gubellini, Alistair N. Garratt, Bernard Jacq, Ahmed Fatmi, Pascal Salin, Dorian Chabbert, Xavier Caubit, Bianca Habermann, Lydia Kerkerian-Le Goff, Emeric Dubois

Publikováno v: Biological Psychiatry
Biological Psychiatry, Elsevier, 2019, 86 (4), pp.274-285. ⟨10.1016/j.biopsych.2019.03.974⟩
Biological Psychiatry, 2019, 86 (4), pp.274-285. ⟨10.1016/j.biopsych.2019.03.974⟩

International audience; BACKGROUND: Heterozygous deletion of the TSHZ3 gene, encoding for the teashirt zinc-finger homeobox family member 3 (TSHZ3) transcription factor that is highly expressed in cortical projection neurons (CPNs), has been linked t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbf5abb350369b7cee3b04f42362f43
http://edoc.mdc-berlin.de/18222/1/18222oa.pdf