Výsledky vyhledávání - "MESH : Gene Expression Regulation, Bacterial/physiology"

Capsular Switching in Group B Streptococcus CC17 Hypervirulent Clone: A Future Challenge for Polysaccharide Vaccine Development

Autor: Agnès Fouet, Claire Poyart, Anne Six, Samuel Bellais, Philippe Glaser, Magalie Longo, Patrick Trieu-Cuot, Nicolas Dmytruk

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 206 (11), pp.1745-1752. ⟨10.1093/infdis/jis605⟩
Journal of Infectious Diseases, 2012, 206 (11), pp.1745-1752. ⟨10.1093/infdis/jis605⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 206 (11), pp.1745-1752. 〈10.1093/infdis/jis605〉

Background. The capsular polysaccharide (CPS) is an important virulence factor and a vaccine target of the major neonatal pathogen group B Streptococcus (GBS). Population studies revealed no strong correlation between CPS type and multilocus sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e26b170049a14f59bf0d350a0b17fee
https://hal-pasteur.archives-ouvertes.fr/pasteur-01300172

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Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile

Autor: Olga Soutourina, Marc Monot, Bruno Dupuy, Isabelle Martin-Verstraete, Laure Saujet, Eliane Hajnsdorf, Pierre Boudry, Joël Caillet, Céline Gracia

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, 2014, 196 (18), pp.3234-3248. ⟨10.1128/JB.01923-14⟩
Journal of Bacteriology, American Society for Microbiology, 2014, 196 (18), pp.3234-3248. ⟨10.1128/JB.01923-14⟩
Journal of Bacteriology, American Society for Microbiology, 2014, 196 (18), pp.3234-48. ⟨10.1128/JB.01923-14⟩

Clostridium difficile is an emergent human pathogen and the most common cause of nosocomial diarrhea. Our recent data strongly suggest the importance of RNA-based mechanisms for the control of gene expression in C. difficile . In an effort to underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbbd081bd82c114df38b363f02fad51
https://pubmed.ncbi.nlm.nih.gov/24982306

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The C-terminal domain of the virulence factor MgtC is a divergent ACT domain

Autor: Martin Cohen-Gonsaud, Anne-Béatrice Blanc-Potard, Laurent Kremer, Kevin Esteves, Séverine Carrère-Kremer, Gilles Labesse, Yinshan Yang

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2012, 194 (22), pp.6255-6263. ⟨10.1128/JB.01424-12⟩

MgtC is a virulence factor of unknown function important for survival inside macrophages in several intracellular bacterial pathogens, including Mycobacterium tuberculosis . It is also involved in adaptation to Mg 2+ deprivation, but previous work su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d826d22296c20ff258ff4859a88fcbe
https://pubmed.ncbi.nlm.nih.gov/22984256

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Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE

Autor: Revathi Govind, Bruno Dupuy

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2012, 8 (6), pp.e1002727. ⟨10.1371/journal.ppat.1002727⟩
PLoS Pathogens, 2012, 8 (6), pp.e1002727. ⟨10.1371/journal.ppat.1002727⟩
PLoS Pathogens, Vol 8, Iss 6, p e1002727 (2012)

The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea, is mainly associated with the production and activities of two major toxins. In many bacteria, toxins are released into the extracellular environment via th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f683a5e87ae2db20f986130a75090c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02440910

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Clostridium difficile toxin synthesis is negatively regulated by TcdC

Autor: Revathi Govind, Ana Antunes, Susana Matamouros, Bruno Dupuy

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, 2008, 57 (6), pp.685-689. ⟨10.1099/jmm.0.47775-0⟩
Journal of Medical Microbiology, Society for General Microbiology, 2008, 57 (6), pp.685-689. ⟨10.1099/jmm.0.47775-0⟩

Clostridium difficile toxin synthesis is growth phase-dependent and is regulated by various environmental signals. The toxin genes tcdA and tcdB are located in a pathogenicity locus, which also includes three accessory genes, tcdR, tcdC and tcdE. Tcd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5065ea629ee864e3cd422b757926d6e
https://pubmed.ncbi.nlm.nih.gov/18480323

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Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

Autor: Bruno Dupuy, Nagraj Mani

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2001, 98 (10), pp.5844-5849. ⟨10.1073/pnas.101126598⟩
Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (10), pp.5844-5849. ⟨10.1073/pnas.101126598⟩

Clostridium difficile , a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8c01649ca811c6517b63f8d05f526b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02445958

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Regulated transcription of Clostridium difficile toxin genes

Autor: Abraham L. Sonenshein, Bruno Dupuy

Publikováno v: Molecular Microbiology
Molecular Microbiology, 1998, 27 (1), pp.107-120. ⟨10.1046/j.1365-2958.1998.00663.x⟩
Molecular Microbiology, Wiley, 1998, 27 (1), pp.107-120. ⟨10.1046/j.1365-2958.1998.00663.x⟩

International audience; The Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic‐associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene‐specific pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643831c5505264df4cb5f493ae6550d
https://pubmed.ncbi.nlm.nih.gov/9466260

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icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

Autor: Claude Parsot, Philippe J. Sansonetti, Joëlle Mounier, Marie-Christine Prévost, Abdelmounaaim Allaoui

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 1992, 6 (12), pp.1605-1616. ⟨10.1111/j.1365-2958.1992.tb00885.x⟩
Molecular Microbiology, 1992, 6 (12), pp.1605-1616. ⟨10.1111/j.1365-2958.1992.tb00885.x⟩

International audience; Shigella flexneri causes baclllary dysentery by invading epithelial cells of the colonic mucosa. We have characterized the icsB gene which is located on the virulence plasmid pWRIOO. After inactivation of icsB, the mutant stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6945fb1fd58f19632d85a9794c2c1a
https://pubmed.ncbi.nlm.nih.gov/1495389

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