Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy

Autor: Sonia Ait-Younes, Mourad Belkhelfa, Chafia Touil-Boukoffa, Yvan de Launoit, Hassen Mahfouf, Hayet Rafa, Nadira Delhem, Hayat Ait-Kaci, Olivier Moralès, Sabah Hetit, Oussama Medjeber, Sarra Benkhelifa, Said Belhadef

Publikováno v: Inflammopharmacology
Inflammopharmacology, Springer Verlag, 2019, 27 (4), pp.685-700. ⟨10.1007/s10787-019-00566-9⟩
Inflammopharmacology, 2019, 27 (4), pp.685-700. ⟨10.1007/s10787-019-00566-9⟩

International audience; Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c14e2c54400f0d81e84b20996df275
https://hal.archives-ouvertes.fr/hal-03059991

FOXE3 mutations: Genotype-phenotype correlations

Autor: H. Dollfus, Gilles Morin, J. C. Kaplan, Christine Francannet, Hélène Colineaux, Nicola K. Ragge, Daphné Lehalle, Nicolas Chassaing, Julie Plaisancié, Patrick Calvas

Publikováno v: Clinical Genetics
Clinical Genetics, Wiley, 2018, 93 (4), pp.837-845. ⟨10.1111/cge.13177⟩

International audience; Microphthalmia and anophthalmia (MA) are severe developmental eye anomalies, many of which are likely to have an underlying genetic cause. More than 30 genes have been described, each of which is responsible for a small percen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9eaeda59f506912a4df0c029bf6b91
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03160633

Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis

Autor: Patrick Jouandin, Stéphane Noselli, Christian Ghiglione

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2014, 141 (15), pp.3013-21
Development (Cambridge, England), Company of Biologists, 2014, 141 (15), pp.3013-21
HAL

International audience; When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2bca95d402c9539de49b3b59390f10
https://doi.org/10.1242/dev.108399

Signalling pathways regulating muscle mass in ageing skeletal muscle

Autor: Luana Toniolo, L. Barberi, Astrid Y. Bijlsma, Antonio L. Serrano, Carel G. M. Meskers, Lars Larsson, Mario Pende, Rosario Rizzuto, Marco Sandri, Kenneth A. Dyar, Cristina Mammucari, Andrea B. Maier, Giorgia Pallafacchina, M. Roceri, Pura Muñoz-Cánoves, Stefano Schiaffino, Antonio Paoli, D. Pion, Giulia Milan, Bert Blaauw, Antonio Musarò, Carlo Reggiani, Vanina Romanello

Publikováno v: Biogerontology, 14(3), 303-23. Springer Netherlands
Biogerontology
Biogerontology, Springer Verlag, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology; Vol 14
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Munoz-Canoves, P, Musaro, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-323 . https://doi.org/10.1007/s10522-013-9432-9
Biogerontology, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology, 14(3), 303-323. Springer Netherlands
Biogerontology, 14(3), 303-323
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Muñoz-Cánoves, P, Musarò, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle : the role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-23 . https://doi.org/10.1007/s10522-013-9432-9

International audience; During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle mass and force and a major cause of physical frailty. To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f4a5d65f36ee74ba4de2ecd531c858
https://hdl.handle.net/1871.1/c3edf814-3c90-4667-8713-c3a120aff07a

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

Autor: Roger Lauener, Vera Isabel Casaca, Caroline Roduit, R. Frei, Juha Pekkanen, Anna Lluis, Josef Riedler, Jean-Charles Dalphin, Harald Renz, Marie-Laure Dalphin, S. Remes, Michael Kabesch, Maija-Riitta Hirvonen, Béatrice Gaugler, Dominique A. Vuitton, Jon Genuneit, Jörg Tost, Juliane Weber, Georg Loss, Diana Raedler, Marjut Roponen, Philippe Saas, Vincent Kaulek, Gisela Büchele, Anne Hyvärinen, Charlotte Braun-Fahrländer, Jing Liu, Martin Depner, Bianca Schaub, Pekka Tiittanen, Erika von Mutius, Gert Doekes, S. Bitter, Petra Ina Pfefferle, Sven Michel, Anne M. Karvonen

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2014, 133 (2), pp.551-9. 〈10.1016/j.jaci.2013.06.034〉
Journal of Allergy and Clinical Immunology, Elsevier, 2014, 133 (2), pp.551-9. ⟨10.1016/j.jaci.2013.06.034⟩
Journal of Allergy and Clinical Immunology, 2014, 133 (2), pp.551-9. ⟨10.1016/j.jaci.2013.06.034⟩

International audience; BACKGROUND: European cross-sectional studies have suggested that prenatal and postnatal farm exposure decreases the risk of allergic diseases in childhood. Underlying immunologic mechanisms are still not understood but might b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fface7f339e704df55db59bd36d0c6f0
https://hal.archives-ouvertes.fr/hal-01063986