Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases

Autor: Michael Spedding, Alexandre Henriques, Frédérique René, Cyril Quessada, Alexandra Bouscary, Jean-Philippe Loeffler, Shyuan T. Ngo

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, 2020, 884, pp.173446. ⟨10.1016/j.ejphar.2020.173446⟩
European Journal of Pharmacology, Elsevier, 2020, 884, pp.173446. ⟨10.1016/j.ejphar.2020.173446⟩

International audience; Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults. While it is primarily characterized by the death of upper and lower motor neurons, there is a significant metabolic component involved in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5d2c9bf5526c8fda5405cf68e3ac9c
https://www.hal.inserm.fr/inserm-03376315/file/1-s2.0-S0014299920305380-main.pdf

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Autor: Andrew G. Watts, A. Carlos Frasch, Ricardo Resende, Jean M. H. van den Elsen, Susan J. Crennell, Patricia Marcé, Pedro M. Alzari, Zexin Chen

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩
Chen, Z, Marce Villa, P, Resende, R, Alzari, P M, Frasch, A C, Van Den Elsen, J, Crennell, S & Watts, A 2018, ' The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase ', European Journal of Medicinal Chemistry, vol. 158, pp. 25-33 . https://doi.org/10.1016/j.ejmech.2018.08.089
European Journal of Medicinal Chemistry, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩

The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ddfe1a4a8535e8f8ad3c5e44d9ceac
https://doi.org/10.1016/j.ejmech.2018.08.089

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Autor: Marie Octave, Laurence Pirotton, Audrey Ginion, Valentine Robaux, Sophie Lepropre, Jérôme Ambroise, Caroline Bouzin, Bruno Guigas, Martin Giera, Marc Foretz, Luc Bertrand, Christophe Beauloye, Sandrine Horman

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (23), pp.13129. ⟨10.3390/ijms222313129⟩
International Journal of Molecular Sciences, 22(23). MDPI
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13129
International Journal of Molecular Sciences, Vol 22, Iss 13129, p 13129 (2021)
International journal of molecular sciences, Vol. 22, no. 23, p. 13129 [1-17] (2021)

International audience; Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the ace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d460f33aa769cd4b3b498816c1247
https://doi.org/10.3390/ijms222313129

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

Autor: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩

The identification of new therapeutic strategies against osteosarcoma, the most common primary bone tumor, continues to be a primary goal to improve the outcomes of patients refractory to conventional chemotherapy. Osteosarcoma originates from the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60
https://hal.archives-ouvertes.fr/hal-02383680

Inhibitors of the Neisseria meningitidis PilF ATPase provoke type IV pilus disassembly

Autor: Cedric Couturier, Sylvie Goussard, Guillaume Duménil, Dorian Obino, Youxin Kong, Ximing Xu, Flore Aubey, Stéphane Renard, Catherine Lapeyrere, Judith Souphron, Jean-Philippe Corre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (17), pp.8481-8486. ⟨10.1073/pnas.1817757116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (17), pp.8481-8486. ⟨10.1073/pnas.1817757116⟩

International audience; Despite the availability of antibiotics and vaccines, Neisseria meningitidis remains a major cause of meningitis and sepsis in humans. Due to its extracellular lifestyle, bacterial adhesion to host cells constitutes an attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cd36dd5177d67e6129ff39dca8b82b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03100484/file/Aubey_et_al-Author_manuscript-HAL_Pasteur.pdf