Adaptation of Staphylococcus aureus in a Medium Mimicking a Diabetic Foot Environment

Autor: Claude-Alexandre Gustave, Emmanuel Lemichez, Frédéric Laurent, Catherine Dunyach-Remy, Jean-Philippe Lavigne, Anne Tristan, Christelle Ngba-Essebe, Albert Sotto, Cassandra Pouget

Publikováno v: Toxins
Volume 13
Issue 3
Toxins, 2021, 13 (3), pp.230. ⟨10.3390/toxins13030230⟩
Toxins, Vol 13, Iss 230, p 230 (2021)

Staphylococcus aureus is the most prevalent pathogen isolated from diabetic foot infections (DFIs). The purpose of this study was to evaluate its behavior in an in vitro model mimicking the conditions encountered in DFI. Four clinical S. aureus strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6202446ffb813db4a1276a3f4698842

Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity

Autor: Dennis Schlossarek, Dorothee Childs, Mateusz Wagner, Alexander Erban, Joachim Kopka, Juan Moreno, Urszula Luzarowska, Izabela Wojciechowska, Leonardo Perez de Souza, Rubén Vicente, Monika Kosmacz, Michal Gorka, Aleksandra Skirycz, Bhavana Vegesna, Aleksandra Brzezińska, Andrei Kiselev, Ewelina M. Sokolowska, Jennifer C. Ewald, Marcin Luzarowski, Lothar Willmitzer, Alisdair R. Fernie

Publikováno v: Communications Biology
Communications Biology, Nature Publishing Group, 2021, 4 (1), 15 p. ⟨10.1038/s42003-021-01684-3⟩
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Protein–metabolite interactions are of crucial importance for all cellular processes but remain understudied. Here, we applied a biochemical approach named PROMIS, to address the complexity of the protein–small molecule interactome in the model y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d74a7a22f23f1e3250092622abb758
https://doi.org/10.1038/s42003-021-01684-3

Dichotomous metabolic networks govern human ILC2 proliferation and function

Autor: Carys A. Croft, James P. Di Santo, Antonia Cama, Solenne Marie, Carmen Buchrieser, Davide Topazio, Olimpia Musumeci, Valerie Dardalhon, Laura Surace, Naomi Taylor, Jean-Marc Doisne, Vincent Guillemot, Natalia Petrosemoli, Pedro Escoll, Ido Amit, Anna Thaller

Publikováno v: Nature Immunology
Nature Immunology, 2021, 22 (11), pp.1367-1374. ⟨10.1038/s41590-021-01043-8⟩
Nature Immunology, Nature Publishing Group, 2021, 22 (11), pp.1367-1374. ⟨10.1038/s41590-021-01043-8⟩

Group 2 innate lymphoid cells (ILC2s) represent innate homologs of type 2 helper T cells (TH2) that participate in immune defense and tissue homeostasis through production of type 2 cytokines. While T lymphocytes metabolically adapt to microenvironme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072b6d889432eb5d0e60a3fe6f3aa3b

The adaptive response to iron involves changes in energetic strategies in the pathogen Candida albicans

Autor: Duval, Celia, Macabiou, Carole, Garcia, Camille, Lesuisse, Emmanuel, Camadro, Jean-Michel, Auchère, Françoise, Camadro, Jean‐Michel

Publikováno v: MicrobiologyOpen
MicrobiologyOpen, Wiley, 2019, 9 (2), pp.e970. ⟨10.1002/mbo3.970⟩
MicrobiologyOpen, Vol 9, Iss 2, Pp n/a-n/a (2020)
MicrobiologyOpen, Wiley, In press, pp.e970. ⟨10.1002/mbo3.970⟩

Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases known as candidiasis. Its ability to grow in different morphological forms, such as yeasts or filamentous hyphae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f909be21c72a530d55fc213dc91b73e1
https://hal-cnrs.archives-ouvertes.fr/hal-03452194/document

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Autor: Maren Lindner, Béatrice Pignolet, David Brassat, Petra Hundehege, Maria Eveslage, Melanie Eschborn, Johanna Breuer, Luisa Klotz, Karin Loser, Andreas Schulte-Mecklenbeck, Sven G. Meuth, Judith Austermann, Catharina C. Gross, Nicole Freise, Karin B. Busch, Nicholas Schwab, Giulia Nebel, Tilman Schneider-Hohendorf, Timothy J. Turner, Vilmos Posevitz, Heinz Wiendl, Marie Liebmann, Amit Bar-Or, Martin Herold, Shirin Glander, Belén Torres Garrido, Johannes Roth, Claudia Janoschka, Timo Wirth, Graham R. Campbell, Don J. Mahad, Monika Stoll

Publikováno v: Klotz, L, Eschborn, M, Lindner, M, Liebmann, M, Herold, M, Janoschka, C, Torres Garrido, B, Schulte-Mecklenbeck, A, Gross, C C, Breuer, J, Hundehege, P, Posevitz, V, Pignolet, B, Nebel, G, Glander, S, Freise, N, Austermann, J, Wirth, T, Campbell, G R, Schneider-Hohendorf, T, Eveslage, M, Brassat, D, Schwab, N, Loser, K, Roth, J, Busch, K B, Stoll, M, Mahad, D J, Meuth, S G, Turner, T, Bar-Or, A & Wiendl, H 2019, ' Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects ', Science Translational Medicine, vol. 11, no. 490, eaao5563 . https://doi.org/10.1126/scitranslmed.aao5563
Science Translational Medicine, 11(490):5563. American Association for the Advancement of Science
Science Translational Medicine
Science Translational Medicine, 2019, 11 (490), ⟨10.1126/scitranslmed.aao5563⟩

International audience; Interference with immune cell proliferation represents a successful treatment strategy in T cell-mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (MS). One prominent example is pharmacological i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c6a6928d973af7c45bf548e65e0113
https://hdl.handle.net/20.500.11820/c76c0dcd-4614-4fdc-92e3-04332843a83f