Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy

Autor: Katja Langenfeld, Francina Langa, S. Bastide, François Spitz, Andreas Hörnblad

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.439. ⟨10.1038/s41467-020-20714-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.439. ⟨10.1038/s41467-020-20714-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Developmental genes are often regulated by multiple elements with overlapping activity. Yet, in most cases, the relative function of those elements and their contribution to endogenous gene expression remain poorly characterized. An example of this p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be04ce5d4825aa6c9f9fb2a54ad000b
https://hal.sorbonne-universite.fr/hal-03128817/file/s41467-020-20714-y.pdf

BMP4 patterns Smad activity and generates stereotyped cell fate organisation in spinal organoids

Autor: Nathalie Duval, Célia Vaslin, Xavier Baudin, Vanessa Ribes, Youcef El-Mokhtar Frarma, Stéphane Nedelec, Vincent Contremoulins, Tiago Costa Barata

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2019, 146 (14), pp.dev175430. ⟨10.1242/dev.175430⟩
Development (Cambridge, England), Company of Biologists, 2019, 146 (14), pp.dev175430. ⟨10.1242/dev.175430⟩

Bone Morphogenetic Proteins (BMP) are secreted regulators of cell fate in several developing tissues. In the embryonic spinal cord, they control the emergence of the neural crest, roof plate and distinct subsets of dorsal interneurons. Although a gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d654fec2929ad62a0e5310f395ceca5e
https://hal-pasteur.archives-ouvertes.fr/pasteur-03254035

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy

Autor: Laetitia K. Linares, Andrew V. Hubberstey, Emmanuelle Liaudet-Coopman, Nelly Pirot, Fabienne Desmots, Guy Berchem, Anne-Sophie Bach, Esther Pérez-Gracia, Christine Prébois, Valérie Palissot, Patrice Codogno, Céline Gongora, Salwa Sebti, Sophie Pattingre, Chantal Bauvy

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (11), pp.4115-20. 〈10.1073/pnas.1313618111〉
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (11), pp.4115-20. ⟨10.1073/pnas.1313618111⟩
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (11), pp.4115-20. ⟨10.1073/pnas.1313618111⟩
Biological Sciences Publications

International audience; Autophagy is regulated by posttranslational modifications, including acetylation. Here we show that HLA-B-associated transcript 3 (BAT3) is essential for basal and starvation-induced autophagy in embryonic day 18.5 BAT3(-/-) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cbd9bbdfb06ff6067a9638666a9d10
https://doi.org/10.1073/pnas.1313618111

Mesoderm patterning by a dynamic gradient of retinoic acid signalling

Autor: Sigolène M. Meilhac, Ségolène Bernheim

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020, 375 (1809), pp.20190556. ⟨10.1098/rstb.2019.0556⟩
Philos Trans R Soc Lond B Biol Sci

Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in 1983. Identification of its natural presence in the embryo and dissection of its molecular mechanism of action became possible in the animal model with the adv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf49b122dc30bcfa73ed63a5d9c50a9
https://doi.org/10.1098/rstb.2019.0556

Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development

Autor: Maïmouna Coura, Koné, Renaud, Fleurot, Martine, Chebrout, Pascale, Debey, Nathalie, Beaujean, Amélie, Bonnet-Garnier

Publikováno v: Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2016, 94 (4), pp.95. ⟨10.1095/biolreprod.115.136366⟩

International audience; The nucleolus is a dynamic nuclear compartment that is mostly involved in ribosome subunit biogenesis; however, it may also play a role in many other biological processes, such as stress response and the cell cycle. Mainly usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::809af4674c6665ca14a991d11ff2250e
https://hal.archives-ouvertes.fr/hal-02365191/file/BIOLREPROD-2015-136366v3-Beaujean.pdf