Výsledky vyhledávání - "MESH : Drug-Induced Liver Injury"

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

Autor: Julie Massart, Bernard Fromenty, Annie Borgne-Sanchez, Karima Begriche, Marie-Anne Robin

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2011, 54 (4), pp.773-94. ⟨10.1016/j.jhep.2010.11.006⟩
Journal of Hepatology, 2011, 54 (4), pp.773-94. ⟨10.1016/j.jhep.2010.11.006⟩

International audience; Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450. Depending of thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f582fbb934f743d1cbea6662b615fd
https://doi.org/10.1016/j.jhep.2010.11.006

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Optimization of the HepaRG cell model for drug metabolism and toxicity studies

Autor: Christophe Chesne, André Guillouzo, Christiane Guguen-Guillouzo, Sébastien Anthérieu, Ruoya Li

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2012, 26 (8), pp.1278-85. ⟨10.1016/j.tiv.2012.05.008⟩
Toxicology in Vitro, 2012, 26 (8), pp.1278-85. ⟨10.1016/j.tiv.2012.05.008⟩

International audience; The HepaRG cell line is the first human cell line able to differentiate in vitro into mature hepatocyte-like cells. Our main objective within the framework of the EEC-LIINTOP project was to optimize the use of this cell line f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61594e21424364878e8febcec8debc3c
https://hal.archives-ouvertes.fr/hal-00866017

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Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice

Autor: Julie Pajaud, Bruno Turlin, Jacinthe Aubert, Karima Begriche, Marie-Anne Robin, Matthieu Delannoy, Mitchell R. McGill, Sylvie Lepage, Catherine Lucas-Clerc, Catherine Ribault, Isabelle Morel, Bernard Fromenty, Hartmut Jaeschke

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩

International audience; Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease. The pre-existence of fat accumulation and CYP2E1 indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faefe1d214e569a3bd3923c4e449933
https://www.hal.inserm.fr/inserm-00864718

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Effectiveness and safety of saquinavir/ritonavir in HIV-infected pregnant women: INEMA cohort

Autor: Véronique Reliquet, L. De Saint Martin, G. Le Moal, C. Brunet, E. Bui, N. Winer, Nicolas Venisse, François Raffi, P. Perfezou, T. Jovelin

Publikováno v: Med Mal Infect
Med Mal Infect, 2012, 42 (9), pp.421-8. ⟨10.1016/j.medmal.2012.07.010⟩

International audience; OBJECTIVE: The authors had for aim to describe the effectiveness and the safety of a saquinavir/ritonavir (SQV/r) regimen, 1000/100mg twice daily, in HIV-infected pregnant patients. PATIENTS AND METHOD: We made a prospective a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d3bd973ddd355e6dd7ea1089fb1311
https://pubmed.ncbi.nlm.nih.gov/22938775

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Central role of mitochondria in drug-induced liver injury

Autor: Marie-Anne Robin, Dominique Pessayre, Philippe Lettéron, Richard Moreau, Bernard Fromenty, Alain Berson, Abdellah Mansouri

Publikováno v: Drug Metabolism Reviews
Drug Metabolism Reviews, Taylor & Francis, 2012, 44 (1), pp.34-87. ⟨10.3109/03602532.2011.604086⟩
Drug Metabolism Reviews, 2012, 44 (1), pp.34-87. ⟨10.3109/03602532.2011.604086⟩

International audience; A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events cause mitochondrial membrane disruption. Geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04462534fb0dfa41e2938c66bc95fda4
https://hal.archives-ouvertes.fr/hal-00866123

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Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity

Autor: Knockaert, Laetitia, Fromenty, Bernard, Robin, Marie-Anne

Publikováno v: FEBS Journal
FEBS Journal, 2011, 278 (22), pp.4252-60. ⟨10.1111/j.1742-4658.2011.08357.x⟩
FEBS Journal, Wiley, 2011, 278 (22), pp.4252-60. ⟨10.1111/j.1742-4658.2011.08357.x⟩

International audience; There has been growing evidence that phase I metabolizing enzymes cytochromes P450 (CYPs) are not only located in the endoplasmic reticulum but also in other subcellular compartments and particularly in mitochondria. The prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c9c3ba76e79141f20c040646e22af965
https://hal.science/hal-00739827

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Management of voriconazole hepatotoxicity in a lung transplant patient

Autor: Belaiche, Stéphanie, Roustit, Matthieu, Bedouch, Pierrick, Quetant, Sébastien, Saint-Raymond, Christel, Pison, Christophe

Publikováno v: Transplant Infectious Disease
Transplant Infectious Disease, 2011, 13 (3), pp.309-11. ⟨10.1111/j.1399-3062.2010.00590.x⟩
Transplant Infectious Disease, Wiley, 2011, 13 (3), pp.309-11. ⟨10.1111/j.1399-3062.2010.00590.x⟩

International audience; Lung allograft airway colonization by Aspergillus species is common among lung transplant recipients. We report the case of a 46-year-old female lung transplant outpatient diagnosed with persistent pulmonary Aspergillus coloni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::babd12d2e0290d0f640cc2d3794057ba
https://www.hal.inserm.fr/inserm-00696413

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Incidence and risk factors of severe adverse events with nevirapine-based antiretroviral therapy in HIV-infected women. MTCT-Plus program, Abidjan, Côte d'Ivoire

Autor: Didier K. Ekouevi, Patrick A. Coffie, Aristophane Tanon, Clarisse Amani-Bosse, Elaine J. Abrams, François Dabis, Besigin Tonwe-Gold, Gédéon Bedikou

Publikováno v: BMC Infectious Diseases
BMC Infectious Diseases, BioMed Central, 2010, 10, pp.188. ⟨10.1186/1471-2334-10-188⟩
BMC Infectious Diseases, Vol 10, Iss 1, p 188 (2010)

Background In resource-limited settings where nevirapine-containing regimen is the preferred regimen in women, data on severe adverse events (SAEs) according to CD4 cell count are limited. We estimated the incidence of SAEs according to CD4 cell coun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f136d05fda27c89f237f2d06a3886e
https://www.hal.inserm.fr/inserm-00521956

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Mitochondrial involvement in drug-induced liver injury

Autor: Pessayre, Dominique, Mansouri, Abdellah, Berson, Alain, Fromenty, Bernard

Publikováno v: Handbook of Experimental Pharmacology
Handbook of Experimental Pharmacology, 2010, pp.311-65. ⟨10.1007/978-3-642-00663-0_11⟩
Handbook of Experimental Pharmacology, 2010, 196, pp.311-65. ⟨10.1007/978-3-642-00663-0_11⟩

International audience; Mitochondrial dysfunction is a major mechanism of liver injury. A parent drug or its reactive metabolite can trigger outer mitochondrial membrane permeabilization or rupture due to mitochondrial permeability transition. The la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c50723a49af67f908b66a920436a8f69
https://pubmed.ncbi.nlm.nih.gov/20020267

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