Výsledky vyhledávání - "MESH : DNA-Activated Protein Kinase"

Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo

Autor: Evelyne Jouvin-Marche, Cédric Touvrey, Serge M. Candéias, Chrystelle Couedel, Jean-Pierre de Villartay, Maria Jasin, Pauline Soulas, Rachel Couderc, Patrice N. Marche

Publikováno v: Molecular Immunology
Molecular Immunology, 2008, 45 (12), pp.3383-3391
Molecular Immunology, Elsevier, 2008, 45 (12), pp.3383-91. 〈10.1016/j.molimm.2008.04.004〉
Molecular Immunology, Elsevier, 2008, 45 (12), pp.3383-91. ⟨10.1016/j.molimm.2008.04.004⟩
Molecular Immunology, 2008, 45 (12), pp.3383-91. ⟨10.1016/j.molimm.2008.04.004⟩
Molecular Immunology, Elsevier, 2008, 45 (12), pp.3383-3391

International audience; The assembly of functional immune receptor genes via V(D)J recombination in developing lymphocytes generates DNA double-stranded breaks intermediates that are repaired by non-homologous end joining (NHEJ). This repair pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2d5484d5904194fcef3fc03897ada8
https://hal.science/hal-01948376

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Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

Autor: Ludovic Deriano, David Roth

Publikováno v: Annual Review of Genetics
Annual Review of Genetics, 2013, 47 (1), pp.433-55. ⟨10.1146/annurev-genet-110711-155540⟩
Annual Review of Genetics, Annual Reviews, 2013, 47 (1), pp.433-55. ⟨10.1146/annurev-genet-110711-155540⟩

International audience; DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including cell death. Misrepair is also fraught with danger, especially inap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5f39c5dc152730f4e869a8db520969

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Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway

Autor: Nicolas Foray, Muriel Viau, Aurélie Joubert, Jérôme Gastaldo, Zuzana Bencokova

Publikováno v: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 2008, 654 (1), pp.13-21. ⟨10.1016/j.mrgentox.2008.04.009⟩
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2008, 654 (1), pp.13-21. ⟨10.1016/j.mrgentox.2008.04.009⟩

International audience; Although cadmium still represents a public health problem and despite the fact that it has been classified as an IARC Group-I carcinogen, the molecular and cellular mechanisms responsible for the toxicity and the carcinogenici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db81e2c7a00306ab4037b651a9d93eb3
https://pubmed.ncbi.nlm.nih.gov/18539077

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Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis

Autor: Aline Meulle, Bernard Salles, Catherine Muller, Philippe Valet, Danièle Daviaud

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2008, 3 (10), pp.e3345. ⟨10.1371/journal.pone.0003345⟩
PLoS ONE, 2008, 3 (10), pp.e3345. ⟨10.1371/journal.pone.0003345⟩
PLoS ONE, Vol 3, Iss 10, p e3345 (2008)

International audience; Little information is available on the ability of terminally differentiated cells to efficiently repair DNA double strand breaks (DSBs), and one might reasonably speculate that efficient DNA repair of these threatening DNA les

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7a3b8c9a943b3b3bc8142b52d1cc0c
https://www.hal.inserm.fr/inserm-00409180

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Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways

Autor: Nicolas Foray, Jérôme Gastaldo, Aurélie Joubert, A. M. Charvet, Muriel Viau, Zuzana Bencokova, Jacques Balosso

Publikováno v: Toxicology Letters
Toxicology Letters, 2007, 173 (3), pp.201-14. ⟨10.1016/j.toxlet.2007.08.003⟩
Toxicology Letters, Elsevier, 2007, 173 (3), pp.201-14. ⟨10.1016/j.toxlet.2007.08.003⟩

International audience; Despite a considerable amount of data, evaluation of the potential genotoxicity and cancer proneness of lead compounds remains unclear, probably due to the plethora of experimental procedures, biological endpoints and cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1273a52218823c49928164d2e0f8c5b
https://www.hal.inserm.fr/inserm-00383858

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Irradiation in presence of iodinated contrast agent results in radiosensitization of endothelial cells: consequences for computed tomography therapy

Autor: Aurélie Joubert, Jacques Balosso, François Estève, Thierry Brochard, Nicolas Foray, Marie-Claude Biston, A. M. Charvet, Jean-Luc Ravanat, Caroline Boudou

Publikováno v: International Journal of Radiation Oncology-Biology-Physics
International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2005, 62 (5), pp.1486-96. ⟨10.1016/j.ijrobp.2005.04.009⟩
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics, 2005, 62 (5), pp.1486-96. ⟨10.1016/j.ijrobp.2005.04.009⟩

International audience; PURPOSE: To date, iodinated contrast agents (ICA) are commonly used in medical imaging to improve tumor visualization by attenuating scanners X-rays. However, some adverse reactions to ICAs are still reported, and their molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7678409baa1fa6165bb799cb091cf1f
https://www.hal.inserm.fr/inserm-00388944

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The Ku70 autoantigen interacts with p40phox in B lymphocytes

Autor: Grandvaux N, Grizot S, Pv, Vignais, Marie-Claire DAGHER

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 1999, 112 ( Pt 4), pp.503-13
Journal of Cell Science, 1999, 112 ( Pt 4), pp.503-13
Europe PubMed Central

International audience; Ku70, a regulatory component of the DNA-dependent protein kinase, was identified by a yeast two-hybrid screen of a B lymphocyte cDNA library as a partner of p40phox, a regulatory component of the O2--producing NADPH oxidase. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0596a11c86cd40ce4fd0ffe5018f8349
https://hal.science/hal-00820787

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