Microtubules self-repair in living cells

Autor: Morgan Gazzola, Alexandre Schaeffer, Ciarán Butler-Hallissey, Karoline Friedl, Benoit Vianay, Jérémie Gaillard, Christophe Leterrier, Laurent Blanchoin, Manuel Théry

Publikováno v: Current Biology-CB
Current Biology-CB, 2023, 33 (1), pp.122-133.e4. ⟨10.1016/j.cub.2022.11.060⟩

International audience; Microtubule self-repair has been studied both in vitro and in vivo as an underlying mechanism of microtubule stability. The turnover of tubulin dimers along the microtubule has challenged the pre-existing dogma that only growi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf12c0564d6b3ee5ecc70a7425ac80fc
https://hal.science/hal-04005796

Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects

Autor: Scekic-Zahirovic, Jelena, Sanjuan-Ruiz, Inmaculada, Kan, Vanessa, Megat, Salim, De Rossi, Pierre, Dieterlé, Stéphane, Cassel, Raphaelle, Jamet, Marguerite, Kessler, Pascal, Wiesner, Diana, Tzeplaeff, Laura, Demais, Valérie, Sahadevan, Sonu, Hembach, Katharina M, Muller, Hans-Peter, Picchiarelli, Gina, Mishra, Nibha, Antonucci, Stefano, Dirrig-Grosch, Sylvie, Kassubek, Jan, Rasche, Volker, Ludolph, Albert, Boutillier, Anne-Laurence, Roselli, Francesco, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Liebscher, Sabine, Dupuis, Luc

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3028. ⟨10.1038/s41467-021-23187-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications 12(1), 3028 (2021). doi:10.1038/s41467-021-23187-9
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23187-9⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-23187-9⟩
Nature Communications, 2021, 12 (1), pp.3028. ⟨10.1038/s41467-021-23187-9⟩

Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is also observed in other diseases, with unknown consequences. Here, we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c8536f94d17455134cebd44e2729e13b
https://www.hal.inserm.fr/inserm-03376335

Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization

Autor: Arthur T. Molines, Joël Lemière, Morgan Gazzola, Ida Emilie Steinmark, Claire H. Edrington, Chieh-Ting Hsu, Paula Real-Calderon, Klaus Suhling, Gohta Goshima, Liam J. Holt, Manuel Thery, Gary J. Brouhard, Fred Chang

Publikováno v: Developmental Cell
Developmental Cell, 2022, 57 (4), pp.466-479.e6. ⟨10.1016/j.devcel.2022.02.001⟩
Dev Cell
Molines, A T, Lemière, J, Gazzola, M, Steinmark, I E, Edrington, C H, Hsu, C T, Real-Calderon, P, Suhling, K, Goshima, G, Holt, L J, Thery, M, Brouhard, G J & Chang, F 2022, ' Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization ', Developmental Cell, vol. 57, no. 4, pp. 466-479.e6 . https://doi.org/10.1016/j.devcel.2022.02.001

International audience; The cytoplasm is a crowded, visco-elastic environment whose physical properties change according to physiological or developmental states. How the physical properties of the cytoplasm impact cellular functions in vivo remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da6feb7240a994a01061e2d98ab8fa2
https://pubmed.ncbi.nlm.nih.gov/35231424

Bacterial intracellularly active toxins: Membrane localisation of the active domain

Autor: Michel R. Popoff, Arnaud Blondel, Carolina Varela-Chavez

Publikováno v: Cellular Microbiology
Cellular Microbiology, Wiley, 2020, 22 (7), pp.e13213. ⟨10.1111/cmi.13213⟩
Cellular Microbiology, 2020, 22 (7), pp.e13213. ⟨10.1111/cmi.13213⟩

International audience; Numerous bacterial toxins exert their activity by inactivating or modulating a specific intracellular host target. For this purpose, these toxins have developed efficient strategies to overcome the different host cell defences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb88fa6b84c6bbdb018b32e309d4c3c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261443

Diversification of giant and large eukaryotic dsDNA viruses predated the origin of modern eukaryotes

Autor: Julien Guglielmini, Morgan Gaia, Patrick Forterre, Anthony C. Woo, Mart Krupovic

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (39), pp.19585-19592. ⟨10.1073/pnas.1912006116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (39), pp.19585-19592. ⟨10.1073/pnas.1912006116⟩

Comment in :Reply to Ku and Sun: Ancestors of modern giant and large eukaryotic dsDNA viruses infected proto-eukaryotes./ Guglielmini J, Woo AC, Krupovic M, Forterre P, Gaia M. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2749-2750./ doi: 10.1073/pna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339e7228d81fa50587f993484a9693a9
https://hal.science/hal-02294232