Zobrazeno 1 - 10 of 14 pro vyhledávání: '"MESH : Cytochrome P-450 CYP3A"'
1
The Novel Antibacterial Compound Walrycin A Induces Human PXR Transcriptional Activity
Autor: Céline Gheeraert, Alexandre Berthier, Rémy Le Guével, Gilles Salbert, Patrick Balaguer, Philippe Lefebvre, Bart Staels, Abdel Boulahtouf, Frédérik Oger
Publikováno v: Toxicological Sciences
Toxicological Sciences, Oxford University Press (OUP), 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
Toxicological Sciences, 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
International audience; The human pregnane X receptor (PXR) is a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. PXR is activated by a large, structurally diverse, set of endogenous and xenobiotic compounds and co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419536c58bd00f433a1d7483ea49fe10
https://doi.org/10.1093/toxsci/kfs073
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2
Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART
Autor: Julie, Bertrand, Jean-Marc, Treluyer, Xavière, Panhard, Agnes, Tran, Solange, Auleley, Elisabeth, Rey, Dominique, Salmon-Céron, Xavier, Duval, France, Mentré, X, Panhard
Publikováno v: European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-678. ⟨10.1007/s00228-009-0660-5⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-678. 〈10.1007/s00228-009-0660-5〉
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-78. ⟨10.1007/s00228-009-0660-5⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (7), pp.667-78. 〈10.1007/s00228-009-0660-5〉
International audience; AIMS: To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety. METHODS: Forty protease inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f823f741fa0ce8ce72e9aee66009971a
https://hal.archives-ouvertes.fr/hal-00534961/document
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3
Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients
Autor: Woillard, Jean-Baptiste, Kamar, Nassim, Coste, Sandra, Rostaing, Lionel, Marquet, Pierre, Picard, Nicolas
Publikováno v: Clinical Chemistry
Clinical Chemistry, 2013, 59 (12), pp.1761-9. ⟨10.1373/clinchem.2013.204990⟩
International audience; BACKGROUND: Recent studies have identified new candidate polymorphisms in the genes related to CYP3A activity or calcineurin inhibitor dose requirements in kidney transplant recipients. These genes and polymorphisms are CYP3A4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::adcc1dbb8f1531ade1191ff85049174c
https://www.hal.inserm.fr/inserm-00852753
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4
Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients
Autor: Jean-Baptiste Woillard, Nassim Kamar, Nicolas Picard, Pierre Marquet, Lionel Rostaing, Sandra Coste
Publikováno v: Clinical Chemistry
Clinical Chemistry, American Association for Clinical Chemistry, 2013, 59 (12), pp.1761-9. ⟨10.1373/clinchem.2013.204990⟩
BACKGROUNDRecent studies have identified new candidate polymorphisms in the genes related to CYP3A activity or calcineurin inhibitor dose requirements in kidney transplant recipients. These genes and polymorphisms are CYP3A4 (cytochrome P450, family
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8565c5d04d3c439afd0914abe745b6d2
https://pubmed.ncbi.nlm.nih.gov/23974086
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5
Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors
Autor: Guanghua Yang, Pascale Bouillé, Karim Si-Tayeb, Noushin Dianat, Clémence Martinet, Ludovic Vallier, Rémi Vernet, Denis Clay, Sébastien Corbineau, Anne Weber, Deborah J. Burks, Régis Gayon, Anne Dubart-Kupperschmitt, Gérard Tachdjian, Sylvie Goulinet-Mainot
Publikováno v: BMC BIOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
BMC Biology
BMC Biology, 2013, 11 (1), pp.86. ⟨10.1186/1741-7007-11-86⟩
BMC Biology, BioMed Central, 2013, 11 (1), pp.86. ⟨10.1186/1741-7007-11-86⟩
BMC Biology; Vol 11
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
BackgroundHuman pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods that will permit the transplantati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad81b9af88489354bb747e4ceee07c2
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2002
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6
Effect of adherence as measured by MEMS, ritonavir boosting, and CYP3A5 genotype on atazanavir pharmacokinetics in treatment-naive HIV-infected patients
Autor: Aurélie Barrail-Tran, Bernard Vrijens, Radojka M. Savic, F Mentré, Nembot G, Céline Verstuyft, Xavière Panhard, Diane Descamps, Xavier Duval, Cécile Goujard, Anne-Marie Taburet
Publikováno v: Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2012, 92 (5), pp.575-83. ⟨10.1038/clpt.2012.137⟩
Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2012, 92 (5), pp.575-83. ⟨10.1038/clpt.2012.137⟩
International audience; We investigated population pharmacokinetics and pharmacogenetics of ritonavir-boosted atazanavir (ATV), using drug intake times exactly recorded by the Medication Event Monitoring System. The ANRS 134-COPHAR 3 trial was conduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3535dc101bc9224dee0500849ca3bc65
https://www.hal.inserm.fr/inserm-00747884/document
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7
An adaptation of the human HepaRG cells to the in vitro micronucleus assay
Autor: Alexandra Rogue, André Guillouzo, Rozenn Jossé, Elisabeth Lorge
Publikováno v: Mutagenesis
Mutagenesis, 2012, 27 (3), pp.295-304. ⟨10.1093/mutage/ger076⟩
Mutagenesis, Oxford University Press (OUP), 2012, 27 (3), pp.295-304. ⟨10.1093/mutage/ger076⟩
International audience; The in vitro micronucleus test is considered as an attractive tool for genotoxicity testing of chemicals because of its simplicity of scoring and wide applicability in different cell types. However, most of the cells currently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bd68f9be12713262c96090e676a396
https://hal.science/hal-00739817
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8
Population pharmacokinetic modelling and design of a Bayesian estimator for therapeutic drug monitoring of tacrolimus in lung transplantation
Autor: Martine Reynaud-Gaubert, Romain Kessler, Marc Stern, Pierre Marquet, Caroline Monchaud, Annick Rousseau, Romain Guillemain, Christophe Pison, Brenda C. M. de Winter, Christiane Knoop, Marc Estenne
Publikováno v: Clinical Pharmacokinetics
Clinical Pharmacokinetics, Springer Verlag, 2012, 51 (3), pp.175-86. ⟨10.2165/11594760-000000000-00000⟩
ResearcherID
International audience; BACKGROUND: Therapeutic drug monitoring of tacrolimus is a major support to patient management and could help improve the outcome of lung transplant recipients, by minimizing the risk of rejections and infections. However, des
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3e13259b16b55500f13d7762787ae8
https://www.hal.inserm.fr/inserm-00925698
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9
The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation
Autor: Nicolas Picard, Pierre Marquet
Publikováno v: Expert Opinion on Drug Metabolism and Toxicology
Expert Opinion on Drug Metabolism and Toxicology, Taylor & Francis, 2011, 7 (6), pp.731-43. ⟨10.1517/17425255.2011.570260⟩
International audience; INTRODUCTION: Immunosuppressive drugs have a narrow therapeutic range and large inter-individual response variability. This has prompted pharmacogenetic studies, mostly with regard to their dose-concentration relationships, bu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff6bdbec013c84be1c6ebf26af4f4cc
https://www.hal.inserm.fr/inserm-00577136
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10
CYP3A5 genotype does not influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipients
Autor: Koukeb Rouguieg-Malki, Pierre Marquet, Lionel Rostaing, Nicolas Picard, Nassim Kamar
Publikováno v: Transplantation
Transplantation, Lippincott, Williams & Wilkins, 2011, 91 (6), pp.652-6. ⟨10.1097/TP.0b013e31820ae4ac⟩
International audience; BACKGROUND: CYP3A5 genotyping might be useful to guide tacrolimus and sirolimus dosing. The aim of this study was to assess the influence of CYP3A5 polymorphism on everolimus metabolism and pharmacokinetics. METHODS: We invest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819e35daf9e0f22b7163ee642b29bee4
https://www.hal.inserm.fr/inserm-00542366/file/Manuscrit_CYP3A5_everolimus_Transplantation_.pdf
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