Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Autor: Margaux Sala, Nathalie Allain, Mélanie Moreau, Arnaud Jabouille, Elodie Henriet, Aya Abou-Hammoud, Arnaud Uguen, Sylvaine Di-Tommaso, Cyril Dourthe, Anne-Aurélie Raymond, Jean-William Dupuy, Emilie Gerard, Nathalie Dugot-Senant, Benoit Rousseau, Jean-Phillipe Merlio, Anne Pham-Ledart, Béatrice Vergier, Sophie Tartare-Deckert, Violaine Moreau, Frédéric Saltel

Publikováno v: Oncogene
Oncogene, 2022, 41 (18), pp.2571-2586. ⟨10.1038/s41388-022-02266-1⟩

International audience; Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted therapy is the acqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e902fb034a72453fff297cfa67b184
https://doi.org/10.1038/s41388-022-02266-1

The Transcription Coregulator RIP140 Inhibits Cancer Cell Proliferation by Targeting the Pentose Phosphate Pathway

Autor: Valentin Jacquier, Delphine Gitenay, Vincent Cavaillès, Catherine Teyssier

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7419
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (13), pp.7419. ⟨10.3390/ijms23137419⟩

International audience; Cancer cells switch their metabolism toward glucose metabolism to sustain their uncontrolled proliferation. Consequently, glycolytic intermediates are diverted into the pentose phosphate pathway (PPP) to produce macromolecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fced11079facda3895425416a995e598

Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

Autor: Cherif, Chaïma, Nguyen, Dang Tan, Paris, Clément, Le, Thi Khanh, Sefiane, Thibaud, Carbuccia, Nadine, Finetti, Pascal, Chaffanet, Max, Kaoutari, Abdessamad El, Vernerey, Julien, Fazli, Ladan, Gleave, Martin, Manai, Mohamed, Barthélémy, Philippe, Birnbaum, Daniel, Bertucci, François, Taïeb, David, Rocchi, Palma

Publikováno v: Oncogene
Oncogene, 2022, 41 (1), pp.125-137. ⟨10.1038/s41388-021-02039-2⟩

International audience; Abstract Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We previously showed that heat shock protein 27 (HSP27) acted as a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a298298ed23e27aa7b5f5510d25e24f
https://hal.science/hal-03599176

Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells

Autor: Maria Dalla Pozza, Dolores Fregona, Christophe Orvain, Christian Gaiddon, Chiara Nardon, Leonardo Brustolin, Nicolò Pettenuzzo

Publikováno v: Molecules
Molecules, MDPI, 2021, 26 (13), pp.4073. ⟨10.3390/molecules26134073⟩
Molecules, Vol 26, Iss 4073, p 4073 (2021)
Molecules, 2021, 26 (13), pp.4073. ⟨10.3390/molecules26134073⟩
Volume 26
Issue 13

Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5c0636218209ebc589adc73dc7916c
https://hal.archives-ouvertes.fr/hal-03450763

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

Autor: Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩

International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y