Zobrazeno 1 - 10 of 53 pro vyhledávání: '"MESH : Cell Hypoxia"'
1
Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization
Autor: Dobi, Anthony, Rosanaly, Sarah, Baret, Pascal, Meilhac, Olivier, Harry, G. Jean, Lefebvre d'Hellencourt, Christian, Rondeau, Philippe, Hammad, Noureddine, Bouchez, C.L., Paumard, P., Mazat, J.P., Scherlinger, Marc, Lykkesfeldt, Jens, Bouchez, Cyrielle, Yoboue, Edgar, de la Rosa Vargas, Livier, Salin, Bénédicte, Cuvellier, Sylvain, Rigoulet, Michel, Duvezin-Caubet, Stéphane, Mazat, Jean-Pierre, Ransac, Stéphane, Tinevez, Jean-Yves, Arena, Ellen, Anderson, Mark, Nigro, Giulia, Injarabian, Louise, André, Antonin, Ferrari, Mariana, Campbell-Valois, François-Xavier, Devin, Anne, Shorte, Spencer, Sansonetti, Philippe, Marteyn, Benoit
Publikováno v: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2019, 4 (11), pp.2001-2009. ⟨10.1038/s41564-019-0525-3⟩
Nature Microbiology, 2019, 4 (11), pp.2001-2009. ⟨10.1038/s41564-019-0525-3⟩
Nature microbiology
Pathogenic enterobacteria face various oxygen (O2) levels during intestinal colonization from the O2-deprived lumen to oxygenated tissues. Using Shigella flexneri as a model, we have previously demonstrated that epithelium invasion is promoted by O2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a041e5775ce3db3812b359f4e60ee49
https://hal.archives-ouvertes.fr/hal-03009534
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2
SUMO and the robustness of cancer
Autor: Anne Dejean, Jacob-Sebastian Seeler
Publikováno v: Nature Reviews Cancer
Nature Reviews Cancer, Nature Publishing Group, 2017, 17 (3), pp.184-197. ⟨10.1038/nrc.2016.143⟩
Nature Reviews Cancer, 2017, 17 (3), pp.184-197. ⟨10.1038/nrc.2016.143⟩
International audience; Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d749cf57885c8c2f709eda4be16e45e
https://pubmed.ncbi.nlm.nih.gov/28134258
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4
Hypoxia Down-regulates CCAAT/Enhancer Binding Protein-α Expression in Breast Cancer Cells
Autor: Robert Barouki, Etienne Blanc, Nathalie M. Mazure, Fabrice Lecuru, Marie-Claude Fulchignoni-Lataud, Marie-Aude Le Frere Belda, Anne Dreiem, Thérèse Hervèe Mayi, Charbel Massaad, Vincent Favaudon, Liliane Massaad-Massade, Ramzi Seifeddine
Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2008, 68 (7), pp.2158-65. ⟨10.1158/0008-5472.CAN-07-1190⟩
Cancer Research, 2008, 68 (7), pp.2158-65. ⟨10.1158/0008-5472.CAN-07-1190⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (7), pp.2158-65. 〈10.1158/0008-5472.CAN-07-1190〉
International audience; The transcription factor CCAAT/enhancer binding protein-alpha (C/EBP alpha) is involved in the control of cell differentiation and proliferation, and has been suggested to act as a tumor suppressor in several cancers. By using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b155d9f81fcc6f41e3f4818c19beb9a0
https://doi.org/10.1158/0008-5472.can-07-1190
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5
Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome
Autor: Sandra Lacas-Gervais, Baharia Mograbi, Amine Belaid, Christophe Duranton, Marc Cougnon, Sébastien Giraud, Christian Frelin, Didier F. Pisani, Michel Tauc, Nicolas Melis, Nicolas Blondeau, Paul Vigne, Konstantina Fragaki, Stephan M. Huber, Thierry Hauet, Isabelle Rubera
Publikováno v: Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (3), pp.811-822. ⟨10.1681/ASN.2016010012⟩
International audience; The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6458b8364eefd67670a482c6116d32
https://europepmc.org/articles/PMC5328152/
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6
Importance of local hypoxia on endothelial phenotype for an in vitro approach to bone marrow angiogenesis
Autor: Marc Vasse, Jean-Pierre Vannier, Isabelle Dubus, Sophie Kamanzi, Flore Gouel, Cécile Corbière, Paul Mulder, Elisabeth Legrand, Catherine Buquet
Publikováno v: Leukemia Research
Leukemia Research, Elsevier, 2012, 36 (9), pp.1200-1203. ⟨10.1016/j.leukres.2012.05.026⟩
International audience; The vasculature of bone marrow differs from that in other organs, and its characteristics should be considered when exploring the medullar angiogenesis associated with hematological malignancies. We show here that the human bo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394d509929bf4c76f6ca501302d11a74
https://doi.org/10.1016/j.leukres.2012.05.026
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7
Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation
Autor: Regina P. Markus, Cathy Vaillancourt, Lucas Sagrillo-Fagundes, Eugania Maria Assuncao Salustiano, Rodrigo Ruano
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Pineal Research
Journal of Pineal Research, Wiley, 2018, 65 (4), pp.e12520. ⟨10.1111/jpi.12520⟩
International audience; Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such as autophagy, inflammation, and apoptosis. Pathological pregnancies, such as preeclampsia, are associated wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49823b5b33758abba1805f9d241d97f
https://doi.org/10.1111/jpi.12520
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8
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer
Autor: R. E. Ammadi, Marius Ilie, Paul Hofman, Jacques Pouysségur, Véronique Hofman, Jérôme Mouroux, Cécile Ortholan, Katia Havet, Christelle Bonnetaud, Baharia Mograbi, Nicolas Venissac, Nathalie M. Mazure
Publikováno v: British Journal of Cancer; Vol 102
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2010, 102 (11), pp.1627-35. ⟨10.1038/sj.bjc.6605690⟩
International audience; BACKGROUND: Carbonic anhydrase IX (CAIX) is an enzyme upregulated by hypoxia during tumour development and progression. This study was conducted to assess if the expression of CAIX in tumour tissue and/or plasma can be a progn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d9fa61598e5a5fee34cfb2eb025acf
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9
Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis
Autor: Anne Rullier, Nathalie Dugot-Senant, Jean Rosenbaum, Jennifer Gillibert-Duplantier, Gérard Déléris, Cyril Petibois, Pierre Costet, Gaelle Cubel, Valérie Haurie, Paulette Bioulac-Sage, Danièle Taras
Publikováno v: AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, 2008, 294 (1), pp.G226-35. ⟨10.1152/ajpgi.00444.2007⟩
Thrombin inhibition protects against liver fibrosis. However, it is not known whether the thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease-activated receptors (PARs). We took advantage of the lack of b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d43669519b81c8d6853c718c7987ecf
https://doi.org/10.1152/ajpgi.00444.2007
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10
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Autor: Edurne Berra, Paul N. Moynagh, Jacques Pouysségur, Cormac T. Taylor, Amandine Ginouvès, Katrina M. Comerford, Kathleen T. Fitzgerald, Jens Erik Nielsen, Catherine Godson, Fergal Seeballuck, Eoin P. Cummins
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (48), pp.18154-9. ⟨10.1073/pnas.0602235103⟩
Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFkappaB is activated in hypoxia, an event that has significant implications for tumor progression. Here, we demonstrate that hypoxia activates NFkappaB through
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2fc76991bf7178c5c22446765558ed
https://doi.org/10.1073/pnas.0602235103
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