CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Autor: Marius Ringelstein, L. M. Yshii, Ilka Kleffner, Stephen W. Reddel, Brigitte Wildemann, Todd A. Hardy, Markus Schwaninger, Guillaume Martin-Blondel, Nicholas Schwab, Delphine Loussouarn, John Parratt, Marc Pawlitzki, Henrike Plate, Eduardo Beltrán, Catharina C. Gross, Anna R. Tröscher, Tanja Kuhlmann, Tilman Schneider-Hohendorf, Klaus Dornmair, Jan Dörr, Roland S. Liblau, Urvashi Bhatia, Hans Lassmann, Sven G. Meuth, Luisa Klotz, Sebastian Herich, Markus Kraemer, Jan Bauer, Céline Meyer, David-Axel Laplaud, Wolfgang Brück, Romana Höftberger, Michael Barnett, Michael E. Buckland, Andreas Schulte-Mecklenbeck, Heinz Wiendl

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5779. ⟨10.1038/s41467-019-13593-5⟩
Nature Communications, 2019, 10, pp.5779. ⟨10.1038/s41467-019-13593-5⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

International audience; Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca645613d7be9f13495f97945a31e9dd
https://www.hal.inserm.fr/inserm-02448919/file/s41467-019-13593-5.pdf

Targeting α1 inserted domain (I) of α1β1 integrin by Lebetin 2 from M. lebetina transmediterranea venom decreased tumorigenesis and angiogenesis

Autor: Zaineb Abdelkafi-Koubaa, Mohamed El Ayeb, Erij Messadi, Najet Srairi Abid, Maram Morjen, Jed Jebali, Houcemeddine Othman, José Luis, Naziha Marrakchi

Publikováno v: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩

International audience; Through the recent development of knowledge in biotechnology and bioinformatics, snake venoms are widely used to develop new drugs to treat diseases such as hypertension and cancer. We have previously reported that Lebetin 2 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e51ea875cbc6ee35aa79287c5c9f3b
https://doi.org/10.1016/j.ijbiomac.2018.05.230

The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein

Autor: Lamia Borchani, Ivana Catacchio, Antonio Giovanni Solimando, Hafed Majdoub, Imen Jridi, Maria Antonia Frassanito, Delavar Shahbazzadeh, Angelo Vacca, Mohamed El Ayeb, Domenico Ribatti

Publikováno v: Toxicon
Toxicon, Elsevier, 2017, 126, pp.38-46. ⟨10.1016/j.toxicon.2016.12.001⟩

International audience; In a previous study, we reported the identification of Hemilipin, the first secreted heterodimeric phospholipase A2 (sPLA2) from Hemiscorpius lepturus scorpion venom and demonstrated its effective inhibition of all angiogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95314e4d3c0dadcf15c9e75a135888ce
https://doi.org/10.1016/j.toxicon.2016.12.001

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

Autor: Jose Ursic-Bedoya, Isabelle Doignon, Hayat Simerabet, Dominique Rainteau, Doris Cassio, Nicolas Kahale, Anne Davit-Spraul, Thierry Tordjmann, Grégory Merlen, Lydie Humbert, Catherine Guettier, Julien Gautherot, Valeska Bidault-Jourdainne, Christoph Ullmer, Isabelle Garcin, Noémie Péan, Klaus Ebnet, Zahra Tanfin

Publikováno v: Gut
Gut, BMJ Publishing Group, 2019, 69 (1), pp.146-157. ⟨10.1136/gutjnl-2018-316975⟩
Gut, 2019, 69 (1), pp.146-157. ⟨10.1136/gutjnl-2018-316975⟩

ObjectiveWe explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability.DesignExperime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660294abb0fa3eb398b53de0626d479f
https://hal.umontpellier.fr/hal-03356970

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

Autor: Emma Partiot, Nilda Vanesa Ayala-Nunez, Jacky G. Goetz, Gautier Follain, Judith R.E. Roels, Anita Eckly, Béatrice Uring-Lambert, Maxime Chazal, Raphael Gaudin, Gillian Hale, Frank M. J. Jacobs, Sandrine Bourdoulous, Orestis Faklaris, Sherif R. Zaki, Aurélie Hirschler, Nolwenn Jouvenet, Margot Carocci, Florian Bakoa, Sarah Cianférani, Christine Carapito, Frédéric Doussau, Brigid C. Bollweg, François Delalande

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-12408-x⟩
Nature Communications, 10(1):4430. Nature Publishing Group

Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the bloodstream to tissues through a mature endothelium, remains unclear. Here, we show that ZIKV-infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde45bf7344e2f30ce082f9779330683
https://hal.archives-ouvertes.fr/hal-02327473/file/s41467-019-12408-x.pdf