A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Autor: Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Christophe, Jamin, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valérie, Boudjeniba, Cheïma, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodríguez-Pintó, Ignasi, de Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovács, László, Witte, Torsten, Bettacchioli, Eléonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Borghi, Maria Orietta, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickaël, Moingeon, Philippe, Alarcón-Riquelme, Marta, Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabel, Gonzalez-Gay Mantecón, Miguel Angel, Blanco Alonso, Ricardo, Corrales Martínez, Alfonso, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Aguirre-Zamorano, Ma Angeles, Escudero-Contreras, Alejandro, Castro-Villegas, Ma Carmen, Jiménez Gómez, Yolanda, Ortego, Norberto, Fernández Roldán, María Concepción, Raya, Enrique, Jiménez Moleón, Inmaculada, de Ramon, Enrique, Díaz Quintero, Isabel, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Zuber, Aleksandra, Wynar, Donatienne, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Hiepe, Falk, Thiel, Silvia, Rodriguez Maresca, Manuel, López-Berrio, Antonio, Aguilar-Quesada, Rocío, Navarro-Linares, Héctor, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcón Riquelme, Marta, Gomes Anjos, Tania, Marañón, Concepción, Le Lann, Lucas, Simon, Quentin, Rouvière, Bénédicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Gerl, Velia, Khodadadi, Laleh, Cheng, Qingyu, de Groof, Aurélie, Ducreux, Julie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Neves, Esmeralda, Rao, Sambasiva, Jouve, Pierre-Emmanuel

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩

International audience; Abstract There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::61506dd34eed6fb273e9c83af11f3311
https://hal.univ-brest.fr/hal-03301637

Usefulness of MOG-antibody titres at first episode to predict the future clinical course in adults

Autor: Nuria Sola-Valls, Sandra Vukusic, Françoise Durand-Dubief, Eric Thouvenot, Damien Biotti, Hélène Zéphir, Sara Llufriu, Caroline Papeix, Elisabeth Maillart, Romain Deschamps, Nicolas Collongues, Albert Saiz, Pierre Labauge, Alexis Montcuquet, Anne Ruiz, Thaís Armangue, Alvaro Cobo-Calvo, Maria S. Sepúlveda, Xavier Ayrignac, Bertrand Audoin, Jérôme De Seze, Hyacintha d'Indy, Yolanda Blanco, Romain Marignier, Jonathan Ciron

Publikováno v: Journal of Neurology
Journal of Neurology, Springer Verlag, 2019, 266 (4), pp.806-815. ⟨10.1007/s00415-018-9160-9⟩
JOURNAL OF NEUROLOGY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Journal of Neurology, 2019, 266 (4), pp.806-815. ⟨10.1007/s00415-018-9160-9⟩
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

OBJECTIVE: To analyze whether myelin oligodendrocyte glycoprotein antibody (MOG-Ab) titres at onset of the disease were different according to the clinical phenotype at presentation, and to investigate whether the titres were associated with risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5edd78e82876982a3cec2d462341d9b
https://doi.org/10.1007/s00415-018-9160-9

Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases

Autor: Christophe Jamin, Anne Harduin-Lepers, Marie Pierre Morel, Cristina Bagacean, Anne Bordron, Maryvonne Dueymes, Jacques-Olivier Pers, Pierre Pochard

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (7), pp.3402. ⟨10.3390/ijms22073402⟩
International Journal of Molecular Sciences, 2021, 22 (7), pp.3402. ⟨10.3390/ijms22073402⟩
International Journal of Molecular Sciences, Vol 22, Iss 3402, p 3402 (2021)

International audience; Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5611e4ed43dbc2c4eeb8c8c8030000df
http://hdl.handle.net/20.500.12210/39662

Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP

Autor: Andres Männik, Gilles Kaplanski, Kadri Kangro, Elien Roose, Alexandre Curie, Bérangère S. Joly, Claudia Tersteeg, Edwige Tellier, Agnès Veyradier, Paul Coppo, Simon F. De Meyer, Laure De Waele, Karen Vanhoorelbeke

Publikováno v: Blood Advances
Blood Advances, The American Society of Hematology, 2021, 5 (21), pp.4480-4484. ⟨10.1182/bloodadvances.2021004971⟩
Blood Advances, 2021, 5 (21), pp.4480-4484. ⟨10.1182/bloodadvances.2021004971⟩

Key Points An open ADAMTS13 conformation is a novel biomarker for iTTP and is induced by anti-ADAMTS13 autoantibodies.The autoantibodies against the CS region play an important role in the appearance of an open ADAMTS13 conformation.
Immune-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52dc8391436a3577d3b0599050aaaaf
https://hal.sorbonne-universite.fr/hal-03457592/document

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

Autor: Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H. -H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Beziat, V., Manry, J., Shaw, E., Haljasmagi, L., Peterson, P., Lorenzo, L., Bizien, L., Trouillet-Assant, S., Dobbs, K., de Jesus, A. A., Belot, A., Kallaste, A., Catherinot, E., Tandjaoui-Lambiotte, Y., Le Pen, J., Kerner, G., Bigio, B., Seeleuthner, Y., Yang, R., Bolze, A., Spaan, A. N., Delmonte, O. M., Abers, M. S., Aiuti, A., Casari, G., Lampasona, V., Piemonti, L., Ciceri, F., Bilguvar, K., Lifton, R. P., Vasse, M., Smadja, D. M., Migaud, M., Hadjadj, J., Terrier, B., Duffy, D., Quintana-Murci, L., van de Beek, D., Roussel, L., Vinh, D. C., Tangye, S. G., Haerynck, F., Dalmau, D., Martinez-Picado, J., Brodin, P., Nussenzweig, M. C., Boisson-Dupuis, S., Rodriguez-Gallego, C., Vogt, G., Mogensen, T. H., Oler, A. J., Gu, J., Burbelo, P. D., Cohen, J. I., Biondi, A., Bettini, L. R., Dangio, M., Bonfanti, P., Rossignol, P., Mayaux, J., Rieux-Laucat, F., Husebye, E. S., Fusco, F., Ursini, M. V., Imberti, L., Sottini, A., Paghera, S., Quiros-Roldan, E., Rossi, C., Castagnoli, R., Montagna, D., Licari, A., Marseglia, G. L., Duval, X., Ghosn, J., Tsang, J. S., Goldbach-Mansky, R., Kisand, K., Lionakis, M. S., Puel, A., Zhang, S. -Y., Holland, S. M., Gorochov, G., Jouanguy, E., Rice, C. M., Cobat, A., Notarangelo, L. D., Abel, L., H. C., Su, Casanova, J. -L., Arias, A. A., Boisson, B., Boucherit, S., Bustamante, J., Chbihi, M., Chen, J., Chrabieh, M., Kochetkov, T., Le Voyer, T., Liu, D., Nemirovskaya, Y., Ogishi, M., Papandrea, D., Patissier, C., Rapaport, F., Roynard, M., Vladikine, N., Woollett, M., Zhang, P., Kashyap, A., Ding, L., Bosticardo, M., Wang, Q., Ochoa, S., Liu, H., Chauvin, S. D., Stack, M., Koroleva, G., Bansal, N., Dalgard, C. L., Snow, A. L., Abad, J., Aguilera-Albesa, S., Akcan, O. M., Darazam, I. A., Aldave, J. C., Ramos, M. A., Nadji, S. A., Alkan, G., Allardet-Servent, J., Allende, L. M., Alsina, L., Alyanakian, M. -A., Amador-Borrero, B., Amoura, Z., Antoli, A., Arslan, S., Assant, S., Auguet, T., Azot, A., Bajolle, F., Baldolli, A., Ballester, M., Feldman, H. B., Barrou, B., Beurton, A., Bilbao, A., Blanchard-Rohner, G., Blanco, I., Blandinieres, A., Blazquez-Gamero, D., Bloomfield, M., Bolivar-Prados, M., Borie, R., Bousfiha, A. A., Bouvattier, C., Boyarchuk, O., Bueno, M. R. P., Agra, J. J. C., Calimli, S., Capra, R., Carrabba, M., Casasnovas, C., Caseris, M., Castelle, M., Castelli, F., de Vera, M. C., Castro, M. V., Chalumeau, M., Charbit, B., Cheng, M. P., Clave, P., Clotet, B., Codina, A., Colkesen, F., Colobran, R., Comarmond, C., Corsico, A. G., Darley, D. R., Dauby, N., Dauger, S., de Pontual, L., Dehban, A., Delplancq, G., Demoule, A., Di Sabatino, A., Diehl, J. -L., Dobbelaere, S., Durand, S., Eldars, W., Elgamal, M., Elnagdy, M. H., Emiroglu, M., Erdeniz, E. H., Aytekin, S. E., Euvrard, R., Evcen, R., Fabio, G., Faivre, L., Falck, A., Fartoukh, M., Faure, M., Arquero, M. F., Flores, C., Francois, B., Fumado, V., Solis, B. G., Gaussem, P., Gil-Herrera, J., Gilardin, L., Alarcon, M. G., Girona-Alarcon, M., Goffard, J. -C., Gok, F., Gonzalez-Montelongo, R., Guerder, A., Gul, Y., Guner, S. N., Gut, M., Halwani, R., Hammarstrom, L., Hatipoglu, N., Hernandez-Brito, E., Holanda-Pena, M. S., Horcajada, J. P., Hraiech, S., Humbert, L., Iglesias, A. D., Inigo-Campos, A., Jamme, M., Arranz, M. J., Jordan, I., Kanat, F., Kapakli, H., Kara, I., Karbuz, A., Yasar, K. K., Keles, S., Demirkol, Y. K., Klocperk, A., Krol, Z. J., Kuentz, P., Kwan, Y. W. M., Lagier, J. -C., Lau, Y. -L., Le Bourgeois, F., Leo, Y. -S., Lopez, R. L., Leung, D., Levin, M., Levy, M., Levy, R., Li, Z., Linglart, A., Lorenzo-Salazar, J. M., Louapre, C., Lubetzki, C., Luyt, C. -E., Lye, D. C., Mansouri, D., Marjani, M., Pereira, J. M., Martin, A., Pueyo, D. M., Marzana, I., Mathian, A., Matos, L. 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J., Ilovich, A. S., Shahrooei, M., Smadja, D., Sobh, A., Moreno, X. S., Sole-Violan, J., Soler, C., Soler-Palacin, P., Stepanovskiy, Y., Stoclin, A., Taccone, F., Tandjaoui-Lambiottea, Y., Taupin, J. -L., Tavernier, S. J., Thumerelle, C., Tomasoni, G., Toubiana, J., Alvarez, J. T., Trouillet-Assanta, S., Troya, J., Tucci, A., Uzunhan, Y., Vabres, P., Valencia-Ramos, J., van Den Rym, A. M., Vandernoot, I., Vatansev, H., Velez-Santamaria, V., Viel, S., Vilain, C., Vilaire, M. E., Vincent, A., Voiriot, G., Vuotto, F., Yosunkaya, A., Young, B. E., Yucel, F., Zannad, F., Zatz, M., Belota, A., Foti, G., Bellani, G., Citerio, G., Contro, E., Pesci, A., Valsecchi, M. 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M., Prando, C., Pujol, A., Renia, L., Renieri, A., Sancho-Shimizu, V., Sankaran, V., Barrett, K. S., Snow, A., Tangye, S., Turvey, S., Uddin, F., Uddin, M. J., Vazquez, S. E., von Bernuth, H., Washington, N., Zawadzki, P., Sua, H. C., Casanovaa, J. -L.

Publikováno v: Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group & French COVID Cohort Study Group 2020, ' Autoantibodies against type I IFNs in patients with life-threatening COVID-19 ', Science, vol. 370, no. 6515, eabd4585 . https://doi.org/10.1126/science.abd4585
Bastard, P, Rosen, L B, Zhang, Q, Michailidis, E, Hoffmann, H H, Zhang, Y, Dorgham, K, Philippot, Q, Rosain, J, Béziat, V, Manry, J, Shaw, E, Haljasmägi, L, Peterson, P, Lorenzo, L, Bizien, L, Trouillet-Assant, S, Dobbs, K, de Jesus, A A, Belot, A, Kallaste, A, Catherinot, E, Tandjaoui-Lambiotte, Y, Le Pen, J, Kerner, G, Bigio, B, Seeleuthner, Y, Yang, R, Bolze, A, Spaan, A N, Delmonte, O M, Abers, M S, Aiuti, A, Casari, G, Lampasona, V, Piemonti, L, Ciceri, F, Bilguvar, K, Lifton, R P, Vasse, M, Smadja, D M, Migaud, M, Hadjadj, J, Terrier, B, Duffy, D, Quintana-Murci, L, van de Beek, D, Roussel, L, Mogensen, T H, Casanova, J L, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank & COVID Human Genetic Effort 2020, ' Autoantibodies against type I IFNs in patients with life-threatening COVID-19 ', Science, vol. 370, no. 6515, eabd4585 . https://doi.org/10.1126/science.abd4585
Science
Science, American Association for the Advancement of Science, 2020, 370 (6515), pp.eabd4585. ⟨10.1126/science.abd4585⟩
Science (Wayville, S. Aust.) 370 (2020). doi:10.1126/science.abd4585
info:cnr-pdr/source/autori:Paul Bastard # 1 2 3, Lindsey B Rosen # 4, Qian Zhang # 3, Eleftherios Michailidis # 5, Hans-Heinrich Hoffmann # 5, Yu Zhang # 4, Karim Dorgham # 6, Quentin Philippot # 7 2, Jérémie Rosain # 7 2, Vivien Béziat # 7 2 3, Jérémy Manry 7 2, Elana Shaw 4, Liis Haljasmägi 8, Pärt Peterson 8, Lazaro Lorenzo 7 2, Lucy Bizien 7 2, Sophie Trouillet-Assant 9 10, Kerry Dobbs 4, Adriana Almeida de Jesus 4, Alexandre Belot 10 11 12, Anne Kallaste 13, Emilie Catherinot 14, Yacine Tandjaoui-Lambiotte 15, Jeremie Le Pen 5, Gaspard Kerner 7 2, Benedetta Bigio 3, Yoann Seeleuthner 7 2, Rui Yang 3, Alexandre Bolze 16, András N Spaan 3 17, Ottavia M Delmonte 4, Michael S Abers 4, Alessandro Aiuti 18, Giorgio Casari 18, Vito Lampasona 18, Lorenzo Piemonti 18, Fabio Ciceri 18, Kaya Bilguvar 19, Richard P Lifton 19 20 21, Marc Vasse 22, David M Smadja 23, Mélanie Migaud 7 2, Jérome Hadjadj 24, Benjamin Terrier 25, Darragh Duffy 26, Lluis Quintana-Murci 27 28, Diederik van de Beek 29, Lucie Roussel 30 31, Donald C Vinh 30 31, Stuart G Tangye 32 33, Filomeen Haerynck 34, David Dalmau 35, Javier Martinez-Picado 36 37 38, Petter Brodin 39 40, Michel C Nussenzweig 41 42, Stéphanie Boisson-Dupuis 7 2 3, Carlos Rodríguez-Gallego 43 44, Guillaume Vogt 45, Trine H Mogensen 46 47, Andrew J Oler 48, Jingwen Gu 48, Peter D Burbelo 49, Jeffrey I Cohen 50, Andrea Biondi 51, Laura Rachele Bettini 51, Mariella D'Angio 51, Paolo Bonfanti 52, Patrick Rossignol 53, Julien Mayaux 54, Frédéric Rieux-Laucat 24, Eystein S Husebye 55 56 57, Francesca Fusco 58, Matilde Valeria Ursini 58, Luisa Imberti 59, Alessandra Sottini 59, Simone Paghera 59, Eugenia Quiros-Roldan 60, Camillo Rossi 61, Riccardo Castagnoli 62, Daniela Montagna 63 64, Amelia Licari 62, Gian Luigi Marseglia 62, Xavier Duval 65 66 67 68 69, Jade Ghosn 68 69, HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; John S Tsang 70 71, Raphaela Goldbach-Mansky 4, Kai Kisand 8, Michail S Lionakis 4, Anne Puel 7 2 3, Shen-Ying Zhang 7 2 3, Steven M Holland # 4, Guy Gorochov # 6 72, Emmanuelle Jouanguy # 7 2 3, Charles M Rice # 5, Aurélie Cobat # 7 2 3, Luigi D Notarangelo # 4, Laurent Abel # 7 2 3, Helen C Su # 4, Jean-Laurent Casanova/titolo:Autoantibodies against type I IFNs in patients with life-threatening COVID-19/doi:10.1126%2Fscience.abd4585/rivista:Science (Wayville, S. Aust.)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:370
Science, 370 (6515
Science (New York, N.y.)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Science, 370(6515):eabd4585. American Association for the Advancement of Science
Science, 2020, 370 (6515), pp.eabd4585. ⟨10.1126/science.abd4585⟩
Digital.CSIC. Repositorio Institucional del CSIC
Science (New York, N.Y.) 370 (2020). doi:10.1126/science.abd4585
info:cnr-pdr/source/autori:Bastard P.; Rosen L.B.; Zhang Q.; Michailidis E.; Hoffmann H.-H.; Zhang Y.; Dorgham K.; Philippot Q.; Rosain J.; Beziat V.; Manry J.; Shaw E.; Haljasmagi L.; Peterson P.; Lorenzo L.; Bizien L.; Trouillet-Assant S.; Dobbs K.; de Jesus A.A.; Belot A.; Kallaste A.; Catherinot E.; Tandjaoui-Lambiotte Y.; Le Pen J.; Kerner G.; Bigio B.; Seeleuthner Y.; Yang R.; Bolze A.; Spaan A.N.; Delmonte O.M.; Abers M.S.; Aiuti A.; Casari G.; Lampasona V.; Piemonti L.; Ciceri F.; Bilguvar K.; Lifton R.P.; Vasse M.; Smadja D.M.; Migaud M.; Hadjadj J.; Terrier B.; Duffy D.; Quintana-Murci L.; van de Beek D.; Roussel L.; Vinh D.C.; Tangye S.G.; Haerynck F.; Dalmau D.; Martinez-Picado J.; Brodin P.; Nussenzweig M.C.; Boisson-Dupuis S.; Rodriguez-Gallego C.; Vogt G.; Mogensen T.H.; Oler A.J.; Gu J.; Burbelo P.D.; Cohen J.I.; Biondi A.; Bettini L.R.; D'Angio M.; Bonfanti P.; Rossignol P.; Mayaux J.; Rieux-Laucat F.; Husebye E.S.; Fusco F.; Ursini M.V.; Imberti L.; Sottini A.; Paghera S.; Quiros-Roldan E.; Rossi C.; Castagnoli R.; Montagna D.; Licari A.; Marseglia G.L.; Duval X.; Ghosn J.; Tsang J.S.; Goldbach-Mansky R.; Kisand K.; Lionakis M.S.; Puel A.; Zhang S.-Y.; Holland S.M.; Gorochov G.; Jouanguy E.; Rice C.M.; Cobat A.; Notarangelo L.D.; Abel L.; Su H.C.; Casanova J.-L./titolo:Autoantibodies against type I IFNs in patients with life-threatening COVID-19/doi:10.1126%2Fscience.abd4585/rivista:Science (New York, N.Y.)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:370
Science, American Association for the Advancement of Science (AAAS), 2020, 370 (6515), pp.eabd4585. ⟨10.1126/science.abd4585⟩
eabd4585
370:eabd4585
SCIENCE
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

HGID Lab Andrés Augusto Arias1,3, Bertrand Boisson1,2, Soraya Boucherit2, Jacinta Bustamante1,2, Marwa Chbihi2, Jie Chen1, Maya Chrabieh2, Tatiana Kochetkov1, Tom Le Voyer2, Dana Liu1, Yelena Nemirovskaya1, Masato Ogishi1, Dominick Papandrea1, Céci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e45dfdfa6aab0683289a59e92561b44