A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

Autor: Alex Pezzotta, Anna Pistocchi, Patrick Mehlen, Andrea Paradisi, Anna Di Matteo, Federico Forneris, Daniele Campolungo, Costanza Giampietro, Elisa Belloni, Gianluca Deflorian, Nina Volf, Antonella Chiapparino, Michael Rehman, William Vermi, Maria Paola Paronetto, Mattia Bugatti, Davide Pradella, Claudia Ghigna, Anne Eichmann, Matteo Campioni, Serena Zacchigna, Luigi Scietti

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩

The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In the absence of Netrin-1, UNC5B induces apoptosis that is blocked upon Netri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b474c65ef53add8d7c9ee805789f290
https://doi.org/10.1038/s41467-021-24998-6

Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions

Autor: Julia Y. Chu, Sonja Vermeren, Kruthika Sundaram, Ian Dransfield, Hannah Garside, Anne Astier, Utsa Karmakar, Carsten G. Hansen

Publikováno v: Karmakar, U, Chu, J, Sundaram, K, Astier, A, Garside, H, Hansen, C G, Dransfield, I & Vermeren, S 2021, ' Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions ', Cell Death and Disease . https://doi.org/10.1038/s41419-021-03528-8
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (4), ⟨10.1038/s41419-021-03528-8⟩
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Cell Death and Disease, 2021, 12, pp.296. ⟨10.1038/s41419-021-03528-8⟩

Persistent neutrophilic inflammation drives host damage in autoimmune diseases that are characterized by abundant immune complexes. Insoluble immune complexes (iICs) potently activate pro-inflammatory neutrophil effector functions. We and others have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f49e46c9da8740178f10ef7e53310
https://www.pure.ed.ac.uk/ws/files/202899200/Karmakar_et_al_2021_Cell_Death_Disease.pdf

Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents

Autor: Fei Ding, Xiaolong Li, Xianran He, Shaolei Li, Dan Wen, Zhongtang Li, Yuchen Lei, Yongmin Zhang, Yiyan Li, Yangguang Gao, Min Zhong

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 208, pp.112864. ⟨10.1016/j.ejmech.2020.112864⟩

International audience; A series of organoselenium compounds based on the hybridization of nonsteroidal antiinflammatory drugs (NSAIDs) scaffolds and Se functionalities (-SeCN and -SeCF3) were synthesized and characterized, and evaluated against four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5190dbe10ff326f4ff4ae0c766ff7dd
https://hal.sorbonne-universite.fr/hal-03240011/document

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

Autor: Marie-Therese Haider, Laure Cayrefourcq, Nico Hinz, Klaus Pantel, Catherine Alix-Panabières, Daniel J Smit, Manfred Jücker

Publikováno v: Cells
Cells, MDPI, 2020, 9 (9), pp.2129. ⟨10.3390/cells9092129⟩
Volume 9
Issue 9
Cells, Vol 9, Iss 2129, p 2129 (2020)

International audience; Circulating tumor cells (CTCs) are cells shed from the primary tumor into the bloodstream. While many studies on solid tumor cells exist, data on CTCs are scarce. The mortality of cancer is mostly associated with metastasis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329e37a177f287f26f3e0379a18379f2
https://hal.umontpellier.fr/hal-03338498

A new mechanism of resistance to ABL1 tyrosine kinase inhibitors in a BCR-ABL1-positive cell line

Autor: Francois-Xavier Mahon, Kelly Airiau, Béatrice Turcq, Francis Belloc

Publikováno v: Leukemia Research
Leukemia Research, Elsevier, 2017, 61, pp.44-52. ⟨10.1016/j.leukres.2017.08.014⟩

International audience; Tyrosine kinase inhibitors (TKI) constitute the frontline treatment for chronic myeloid leukemia patients. Dasatinib, a second-generation TKI, was developed to overcome TKI resistances. However, dasatinib resistances are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861ed092efc18d7aeee32992aeb58a5c
https://doi.org/10.1016/j.leukres.2017.08.014