Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19

Autor: Lucy Kundura, Sandrine Gimenez, Renaud Cezar, Sonia André, Mehwish Younas, Yea-Lih Lin, Pierre Portalès, Claire Lozano, Charlotte Boulle, Jacques Reynes, Thierry Vincent, Clément Mettling, Philippe Pasero, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Paul Loubet, Albert Sotto, Tu-Anh Tran, Jérôme Estaquier, Pierre Corbeau

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, 150 (3), pp.594-603.e2. ⟨10.1016/j.jaci.2022.06.020⟩

International audience; Background: Lymphopenia is predictive of survival in patients with coronavirus disease 2019 (COVID-19).Objective: The aim of this study was to understand the cause of the lymphocyte count drop in severe forms of severe acute r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219196e32cc7932d8b7c6dd39fab5595
https://doi.org/10.1016/j.jaci.2022.06.020

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction

Autor: Marc Foretz, Moritz Brandt, Eberhard Schulz, Philip Wenzel, Matthias Oelze, John F. Keaney, Swenja Kröller-Schön, Thomas Münzel, Benoit Viollet, Thomas Jansen, Andreas Daiber, Sebastian Steven, Jeremy Lagrange, Miroslava Kvandova, Sanela Kalinovic, Tanja Schönfelder

Publikováno v: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2018, 114 (14), pp.1883-1893. ⟨10.1093/cvr/cvy172⟩

Aims Immune cell function involves energy-dependent processes including growth, proliferation, and cytokine production. Since the AMP-activated protein kinase (AMPK) is a crucial regulator of intracellular energy homeostasis, its expression and activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f84a7bdf168ef53e2d8b9511d6ab39a
https://doi.org/10.1093/cvr/cvy172

Rationale, design and methods of the OSCAR study: observational study on cognitive function and systolic blood pressure reduction in hypertensive patients

Autor: Atul Pathak, Franck Sevenier, Olivier Hanon, Laurence Negre-Pages

Publikováno v: Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2007, 21 (2), pp.199-205. ⟨10.1111/j.1472-8206.2006.00465.x⟩
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2007, 21 (2), pp.199-205. ⟨10.1111/j.1472-8206.2006.00465.x⟩
Fundamental & Clinical Pharmacology, 2007, 21 (2), pp.199-205. 〈10.1111/j.1472-8206.2006.00465.x〉

International audience; Data from several recent clinical trials have suggested a beneficial effect of antihypertensive medications on preservation of cognitive function. Eprosartan, an angiotensin type-1 receptor antagonist (ARA) with dual action on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72632ef47cc62c6bebc7cd39cff86cea
https://doi.org/10.1111/j.1472-8206.2006.00465.x

Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype

Autor: Jean-Pierre Girolami, S. Colie, Christiane Pecher, Nelly Blaes

Publikováno v: International Immunopharmacology
International Immunopharmacology, 2008, 8 (2), pp.231-6. ⟨10.1016/j.intimp.2007.09.006⟩

International audience; There is evidence for a clinical benefit of ACE inhibitors or AT1 antagonists in cardiovascular diseases with deleterious smooth muscle cells (SMC) apoptosis. We have previously shown that angiotensin II (Ang II) induces a phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257595b7856277d5890b25690b6f6f3
https://doi.org/10.1016/j.intimp.2007.09.006

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice

Autor: Sonia Bergaya, Xavier Jeunemaitre, Juliette Hadchouel, Gervaise Loirand, Marc Rio, Jean-Michel Achard, Brigitte Escoubet, Daniel Henrion, Sébastien Faure, Véronique Baudrie, Philippe Bonnin

Publikováno v: Hypertension
Hypertension, American Heart Association, 2011, 58 (3), pp.439-45. ⟨10.1161/HYPERTENSIONAHA.111.172429⟩
Hypertension, 2011, 58 (3), pp.439-45. ⟨10.1161/HYPERTENSIONAHA.111.172429⟩
Hypertension, American Heart Association, 2011, 58 (3), pp.439-45. 〈10.1161/HYPERTENSIONAHA.111.172429〉

Gain-of-function mutations in the human WNK1 ( with-no-lysine[K]1 ) gene are responsible for a monogenic form of arterial hypertension, and WNK1 polymorphisms have been associated with common essential hypertension. The role of WNK1 in renal ionic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efd8ccb865359b39b8a6180b2bab09f
https://hal-unilim.archives-ouvertes.fr/hal-00945534