Výsledky vyhledávání - "MESH : Actins"

Actin Architecture Steers Microtubules in Active Cytoskeletal Composite

Autor: Ondřej Kučera, Jérémie Gaillard, Christophe Guérin, Clothilde Utzschneider, Manuel Théry, Laurent Blanchoin

Publikováno v: Nano Letters
Nano Letters, 2022, 22 (21), pp.8584-8591. ⟨10.1021/acs.nanolett.2c03117⟩

International audience; Motility assays use surface-immobilized molecular motors to propel cytoskeletal filaments. They have been widely used to characterize motor properties and their impact on cytoskeletal self-organization. Moreover, the motility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fd8c973c125b29bc14ab6500dc063c
https://pubmed.ncbi.nlm.nih.gov/36279243

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Actin–microtubule dynamic composite forms responsive active matter with memory

Autor: Ondřej Kučera, Jérémie Gaillard, Christophe Guérin, Manuel Théry, Laurent Blanchoin

Active cytoskeletal materials in vitro demonstrate self-organising properties similar to those observed in their counterparts in cells. However, the search to emulate phenomena observed in the living matter has fallen short of producing a cytoskeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6022f908e460ea87fa959dbf94dd45ea
https://hal.science/hal-03747735

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E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Autor: Cecilia Grimaldi, Jean-Christophe Olivo-Marin, Jan Schick, Jan Bandemer, Erez Raz, Aleix Boquet-Pujadas, Isabel Schumacher, Timo Betz, Anne Aalto, Bart Vos, Katsiaryna Tarbashevich

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5397. ⟨10.1038/s41467-020-19114-z⟩
Nature Communications, 2020, 11 (1), pp.5397. ⟨10.1038/s41467-020-19114-z⟩

The migration of many cell types relies on the formation of actomyosin-dependent protrusions called blebs, but the mechanisms responsible for focusing this kind of protrusive activity to the cell front are largely unknown. Here, we employ zebrafish p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2537d52950ba47be1cd2c9376f634ce
https://doaj.org/article/28360082faba432bb37092c10016f635

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Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy

Autor: Arnaud Echard, Hugo Wioland, Frédérique Cuvelier, Guillaume Romet-Lemonne, Tamara Advedissian, Jian Bai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proc Natl Acad Sci U S A

International audience; Abscission is the terminal step of cytokinesis leading to the physical separation of the daughter cells. In response to the abnormal presence of lagging chromatin between dividing cells, an evolutionarily conserved abscission/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5139df330b93d415d9a12ca7d187948c
https://doi.org/10.1073/pnas.1911629117

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The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity

Autor: Robert-Paganin, Julien, Xu, Xiao-Ping, Swift, Mark F., Auguin, Daniel, Robblee, James P., Lu, Hailong, Fagnant, Patricia M., Krementsova, Elena B., Trybus, Kathleen M., Houdusse, Anne, Volkmann, Niels, Hanein, Dorit

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22093-4⟩
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, 2021, 12 (1), pp.1892. ⟨10.1038/s41467-021-22093-4⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.1892. ⟨10.1038/s41467-021-22093-4⟩

Plasmodium falciparum, the causative agent of malaria, moves by an atypical process called gliding motility. Actomyosin interactions are central to gliding motility. However, the details of these interactions remained elusive until now. Here, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16f578a1e98ec3e1446fa8abc7b3dfd5
https://hal.archives-ouvertes.fr/hal-03365209

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The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity

Autor: Guy Serre, Marie Reynier, Alain Moga, Corinne Leprince, Sophie Allart, Dominique Goudounèche, Michel Simon

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩

International audience; Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LBs), secretor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b23279e57f8e5cb9731c489548ae9e
https://doi.org/10.1016/j.jid.2018.12.021

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Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis

Autor: Caner Akıl, Linh T. Tran, Magali Orhant-Prioux, Yohendran Baskaran, Yosuke Senju, Shuichi Takeda, Phatcharin Chotchuang, Duangkamon Muengsaen, Albert Schulte, Edward Manser, Laurent Blanchoin, Robert C. Robinson

Publikováno v: Communications Biology
Communications Biology, 2022, 5 (1), pp.890. ⟨10.1038/s42003-022-03783-1⟩

Charting the emergence of eukaryotic traits is important for understanding the characteristics of organisms that contributed to eukaryogenesis. Asgard archaea and eukaryotes are the only organisms known to possess regulated actin cytoskeletons. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774cb7a80f1037ad08a0f1c24b7dfc50
https://ousar.lib.okayama-u.ac.jp/63891

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Generation of two isogenic induced pluripotent stem cell lines from a 4-month-old severe nemaline myopathy patient with a heterozygous dominant c.553C > A (p.Arg183Ser) variant in the ACTA1 gene

Autor: Kristen J. Nowak, Edoardo Malfatti, Thierry Larmonier, Gianina Ravenscroft, Carolin K. Scriba, Safaa Saker, Norma B. Romero, Rhonda L. Taylor, Joshua S. Clayton, Nigel G. Laing

Publikováno v: Stem Cell Research
Stem Cell Research, Elsevier, 2021, 53, pp.102273. ⟨10.1016/j.scr.2021.102273⟩
Stem Cell Research, 2021, 53, pp.102273. ⟨10.1016/j.scr.2021.102273⟩
Stem Cell Research, Vol 53, Iss, Pp 102273-(2021)

International audience; AbstractNemaline myopathy (NM) is a congenital myopathy typically characterized by skeletal muscle weakness and the presence of abnormal thread- or rod-like structures (nemaline bodies) in myofibres. Pathogenic variants in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5754eee56df4ce93ce84ffcdfa311f92
https://hal.sorbonne-universite.fr/hal-03176265/file/1-s2.0-S1873506121001197-main.pdf

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Chemokine-biased robust self-organizing polarization of migrating cells in vivo

Autor: Nir S. Gov, Erez Raz, Adan Olguin-Olguin, Anne Aalto, Michal Reichman-Fried, Benoît Maugis, Aleix Boquet-Pujadas, Timo Betz, Dennis Hoffmann, Laura Ermlich

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (7), pp.e2018480118. ⟨10.1073/pnas.2018480118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (7), pp.e2018480118. ⟨10.1073/pnas.2018480118⟩
Proceedings of the National Academy of Sciences
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Significance Bleb-driven cell migration plays important roles in diverse biological processes. Here, we present the mechanism for polarity establishment and maintenance in blebbing cells in vivo. We show that actin polymerization defines the leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31c0901a2689b078fa75458e9cdc0b6
https://hal.sorbonne-universite.fr/hal-03298487

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The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures

Autor: Oualid Sbai, Lotfi Ferhat, Michel Khrestchatisky, Monique Esclapez, Rabia Soussi, Angélique Bole

Publikováno v: Experimental Neurology
Experimental Neurology, 2021, 335, pp.113512. ⟨10.1016/j.expneurol.2020.113512⟩

International audience; α-actinin-2 (α-actn-2) is an F-actin-crosslinking protein, localized in dendritic spines. In vitro studies suggested that it is involved in spinogenesis, morphogenesis, actin organization, cell migration and anchoring of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a0ca9d09bd82f2bf9148b337436cdc
https://hal.science/hal-03452685

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