Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

Autor: James M. Billingsley, Erica H. Parrish, Frank Kirchhoff, Thalia Garcia-Tellez, Nicolas Huot, Guido Silvestri, Ulrike Sauermann, Berit Neumann, Christina M. Stürzel, Gerald H. Learn, Steven E. Bosinger, Christiane Stahl-Hennig, Daniel Sauter, Beatrice H. Hahn, Dietmar Fuchs, Clement W. Gnanadurai, Michaela Müller-Trutwin, Simone Joas, Dominik Hotter, Edina Lump, Cristian Apetrei, Nicholas F. Parrish, Kerstin Mätz Rensing

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications, 2018, 9 (1), pp.1371-1371. ⟨10.1038/s41467-018-03762-3⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1371-1371. ⟨10.1038/s41467-018-03762-3⟩

HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1197f84a4b83f3d4c65fd5483900fedf
http://link.springer.com/article/10.1038/s41467-018-03762-3

Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein

Autor: Coric, Pascale, Saribas, A Sami, Abou-Gharbia, Magid, Childers, Wayne, Condra, Jon, White, Martyn, Safak, Mahmut, Bouaziz, Serge, Saribas, A. Sami

Publikováno v: Journal of Cellular Biochemistry
Journal of Cellular Biochemistry, Wiley, 2017, 118 (10), pp.3268-3280. ⟨10.1002/jcb.25977⟩
Journal of Cellular Biochemistry, 2017, 118 (10), pp.3268-3280. ⟨10.1002/jcb.25977⟩

International audience; Agnoprotein is an important regulatory protein of the human polyoma JC virus (JCV) and plays critical roles during the viral replication cycle. It forms highly stable dimers and oligomers through its Leu/Ile/Phe-rich domain, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5a0edc67baaf2e768c9a86eecbee12
https://hal.archives-ouvertes.fr/hal-02122339

Genetic and phenotypic analyses of sequential vpu alleles from HIV-infected IFN-treated patients

Autor: José Alcamí, Nicoletta Casartelli, Bénédicte Vanwalscappel, Francisco Díez Fuertes, Sylvie Rato, Mayte Pérez-Olmeda, Fabrizio Mammano

Publikováno v: Virology
Virology, Elsevier, 2017, 500, pp.247-258. ⟨10.1016/j.virol.2016.10.028⟩
Virology, 2017, 500, pp.247-258. ⟨10.1016/j.virol.2016.10.028⟩

International audience; Treatment of HIV-infected patients with IFN-α results in significant, but clinically insufficient, reductions of viremia. IFN induces the expression of several antiviral proteins including BST-2, which inhibits HIV by multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd54a6dde6550d72dae3de7a934f8bd6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03253658

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

Autor: Nadine Laguette, Bijan Sobhian, Monsef Benkirane, Stéphane Emiliani, Nicoletta Casartelli, Emmanuel Ségéral, Christine Chable-Bessia, Ahmad Yatim, Olivier Schwartz, Mathieu Ringeard

Publikováno v: Nature; Vol 474
Nature
Nature, Nature Publishing Group, 2011, 474 (7353), pp.654-7. 〈10.1038/nature10117〉
Nature, Nature Publishing Group, 2011, 474 (7353), pp.654-7. ⟨10.1038/nature10117⟩
Nature, 2011, 474 (7353), pp.654-7. ⟨10.1038/nature10117⟩

International audience; The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid cells largely refractory to HIV-1 infection. Here we identify SAMHD1 as this restriction factor. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a911641ed3b37023b8244ac17ee629eb

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo

Autor: Gisela Holz, Thomas Michler, Fabien Zoulim, Mathias Heikenwalder, Julie Lucifora, Ulrike Protzer, Dirk Nierhoff, Hildegard Büning, M. Gruffaz, Rachel Millet, Stephanie Stahnke, Anna Salvetti, David Durantel, Marianna Hösel

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2014, 59 (6), pp.2110-2120. ⟨10.1002/hep.26990⟩
Hepatology 59, 2110-2120 (2014)

Gene therapy has become an accepted concept for the treatment of a variety of different diseases. In contrast to preclinical models, subjects enrolled in clinical trials, including gene therapy, possess a history of infection with microbes that may i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af24630e58a9c581f166ca0fc15ce41b
https://pubmed.ncbi.nlm.nih.gov/24425003