Výsledky vyhledávání - "MESH: Variant Surface Glycoproteins, Trypanosoma"

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Autor: Faria, Joana, Glover, Lucy, Hutchinson, Sebastian, Boehm, Cordula, Field, Mark C., Horn, David

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3023. ⟨10.1038/s41467-019-10823-8⟩

The largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear. Here, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::413ac617aac13601f6d8db9049163309
http://link.springer.com/article/10.1038/s41467-019-10823-8

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VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

Autor: Glover, Lucy, Hutchinson, Sebastian, Alsford, Sam, Horn, David

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (26), pp.7225-7230. ⟨10.1073/pnas.1600344113⟩

International audience; Allelic exclusion underpins antigenic variation and immune evasion in African trypanosomes. These bloodstream parasites use RNA polymerase-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b7c8bd92bc0c933e35e767d855df4ed
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107112

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High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

Autor: David Horn, Sebastian Hutchinson, Lucy Glover

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2016, 17 (1), pp.806. ⟨10.1186/s12864-016-3154-8⟩

Background African trypanosomes cause lethal diseases in humans and animals and escape host immune attack by switching the expression of Variant Surface Glycoprotein (VSG) genes. The expressed VSGs are located at the ends of telomeric, polycistronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ebe3f97020c675c614377c77f5294c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107120/file/s12864-016-3154-8.pdf

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Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

Autor: Glover, Lucy, Horn, David

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (20), pp.12600-12613. ⟨10.1093/nar/gku900⟩

International audience; The African trypanosome, Trypanosoma brucei, is a parasitic protozoan that achieves antigenic variation through DNA-repair processes involving Variant Surface Glycoprotein (VSG) gene rearrangements at subtelomeres. Subtelomeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec21e00e6b17e942085d97b365c3953a
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107111

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Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

Autor: Glover, Lucy, Hutchinson, Sebastian, Alsford, Sam, McCulloch, Richard, Field, Mark, Horn, David

Publikováno v: Cellular Microbiology
Cellular Microbiology, Wiley, 2013, 15 (12), pp.1984-1993. ⟨10.1111/cmi.12215⟩

International audience; African trypanosomes are lethal human and animal parasites that use antigenic variation for evasion of host adaptive immunity. To facilitate antigenic variation, trypanosomes dedicate approximately one third of their nuclear g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec2ffed9bbab73925ef9a8c946290b80
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107113

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Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

Autor: Lucy Glover, Caroline Beattie, David Horn, Sam Alsford

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2007, 35 (3), pp.872-880. ⟨10.1093/nar/gkl1100⟩

International audience; Eukaryotic chromosomes are capped with telomeres which allow complete chromosome replication and prevent the ends from being recognized by the repair machinery. The African trypanosome, Trypanosoma brucei, is a protozoan paras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe9f4c6549f44a41fe52a2b050c92e7
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107105/file/gkl1100.pdf

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Immunology and immunopathology of African trypanosomiasis

Autor: Bernard Bouteille, Philippe Vincendeau

Publikováno v: Anais da Academia Brasileira de Ciências v.78 n.4 2006
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC
Anais da Academia Brasileira de Ciências, Academia Brasileira de Ciências, 2006, 78 (4), pp.645-65
Anais da Academia Brasileira de Ciências, Volume: 78, Issue: 4, Pages: 645-665, Published: DEC 2006
Anais da Academia Brasileira de Ciências, Vol 78, Iss 4, Pp 645-665 (2006)

Major modifications of immune system have been observed in African trypanosomiasis. These immune reactions do not lead to protection and are also involved in immunopathology disorders. The major surface component (variable surface glycoprotein,VSG) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515df32ebbfa056e4bd963b5111798b8
https://pubmed.ncbi.nlm.nih.gov/17143404

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DNA breaks as triggers for antigenic variation in African trypanosomes

Autor: Sam Alsford, Lucy Glover, David Horn

Publikováno v: Genome Biology
Genome Biology, BioMed Central, 2009, 10 (6), pp.223. ⟨10.1186/gb-2009-10-6-223⟩
Scopus-Elsevier

Double-strand breaks initiate coat protein switching in African trypanosomes.
The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c04170b826c4db45345fb26ad70f8e
http://europepmc.org/articles/PMC2718488

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The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands

Autor: Brice Rotureau, Sophie Foulon, Andrew D. Griffiths, Roberta Menafra, Philippe Bastin, Aline Crouzols, Sebastian Hutchinson

Publikováno v: bioRxiv
PLoS Pathogens, Vol 17, Iss 9, p e1009904 (2021)
PLoS Pathogens
PLoS Pathogens, 2021, 17 (9), pp.e1009904. ⟨10.1371/journal.ppat.1009904⟩

The long and complex Trypanosoma brucei development in the tsetse fly vector culminates when parasites gain mammalian infectivity in the salivary glands. A key step in this process is the establishment of monoallelic variant surface glycoprotein (VSG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019cb3eb0cbb164a91cfbd016519e93b

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