SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

Autor: Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩

Funder: Ligue Nationale Contre le Cancer
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552ddce6e8fcc03619460c08b3e7d7a

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

Autor: David G. Schatz, Iannis Aifantis, Panagiotis Ntziachristos, Mariann Micsinai, Joy M. H. Wang, Ludovic Deriano, Yuval Kluger, Jeffrey A. Jeddeloh, Elphège P. Nora, Matthew Rodesch, Julie Chaumeil, Yanhong Ji, Jane A. Skok

Publikováno v: Cell Reports
Cell Reports, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩
CELL REPORTS
Cell Reports, Vol 3, Iss 2, Pp 359-370 (2013)
Cell Reports, Elsevier Inc, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩

International audience; V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3016a3e4331208ba73fa7accb10190e3

Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination

Autor: Michel Cogné, Yves Denizot, Christelle Vincent-Fabert, Pauline Rouaud, Eric Pinaud, Rémi Fiancette

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (11), pp.8356-60. ⟨10.1074/jbc.M112.341024⟩

International audience; V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9abeeb4745a12efd0b4e4e00ca2a443
https://doi.org/10.1074/jbc.m112.341024

Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'

Autor: Sébastien Jaeger, Pierre Ferrier, Bastien Fernandez

Publikováno v: Immunology
Immunology, 2013, 139 (2), pp.141-150. ⟨10.1111/imm.12057⟩
Immunology, Wiley, 2013, 139 (2), pp.141-150. ⟨10.1111/imm.12057⟩

International audience; To perform their specific functional role, B and T lymphocytes, cells of the adaptive immune system of jawed vertebrates, need to express one (and, preferably, only one) form of antigen receptor, i.e. the immunoglobulin or T-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91973b11feb1ef92f196db8b1da63695
https://pubmed.ncbi.nlm.nih.gov/23278765

The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo

Autor: Marie Marquet, Claire Carrion, Pauline Rouaud, Sébastien Bender, Armand Garot, Sandrine Lecardeur, Yves Denizot, Michel Cogné, Eric Pinaud

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 193 (3), pp.1171-83. ⟨10.4049/jimmunol.1302868⟩

The IgH intronic enhancer region Eμ is a combination of both a 220-bp core enhancer element and two 310–350-bp flanking scaffold/matrix attachment regions named MARsEμ. In the mouse, deletion of the core-enhancer Eμ element mainly affects VDJ re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4a398d25b4b24927afdee61f9540be
https://pubmed.ncbi.nlm.nih.gov/24965776