SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Autor: Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird

Publikováno v: Cancer Discovery
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179

Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a6f369ad5cbcb85ed2d339d7aa9050
https://cnrs.hal.science/hal-03759864/document

Advanced Cataloging of Lysine-63 Polyubiquitin Networks by Genomic, Interactome, and Sensor-Based Proteomic Analyses

Autor: Aloysius Wong, Grégory Vert, Dario Monachello, Alexander W. Johnson, Natali Romero-Barrios, Ulla Dolde, Anne Cayrel, Claire Lurin, Hélène San Clemente

Publikováno v: The Plant cell
The Plant cell, American Society of Plant Biologists (ASPB), 2020, 32 (1), pp.123-138. ⟨10.1105/tpc.19.00568⟩
The Plant cell, 2020, ⟨10.1105/tpc.19.00568⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2020, ⟨10.1105/tpc.19.00568⟩

The lack of resolution when studying the many different ubiquitin chain types found in eukaryotic cells has been a major hurdle to our understanding of their specific roles. We currently have very little insight into the cellular and physiological fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac75b82a257c4c1c72c75d675680bdb
https://hal.inrae.fr/hal-03347890

Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin

Autor: Romain Guyot, Jacques Samarut, Karine Gauthier, Frédéric Flamant, Wenyue Guan, Jiemin Wong

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (31), pp.8229-8234. ⟨10.1073/pnas.1702192114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (31), pp.8229-8234. ⟨10.1073/pnas.1702192114⟩

International audience; Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily that act as ligand-dependent transcription factors. Here we identified the ten-eleven translocation protein 3 (TET3) as a TR interacting p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf2b53766639fbc3f46a5f35c84cc8c
https://doi.org/10.1073/pnas.1702192114

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

Autor: Quentin Defenouillère, Elodie Zhang, Abdelkader Namane, Alain Jacquier, Micheline Fromont-Racine, John Mouaikel

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2016, 291 (23), pp.12245-12253. ⟨10.1074/jbc.m116.722264⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (23), pp.12245-12253. ⟨10.1074/jbc.m116.722264⟩

International audience; Protein homeostasis is maintained by quality control mechanisms that detect and eliminate deficient translation products. Cytosolic defective proteins can arise from translation of aberrant mRNAs lacking a termination codon (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49812db36325994775bfab658dbeca33
https://doi.org/10.1074/jbc.m116.722264

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

Autor: Patrick Mehlen, Chantal Thibert, Rémy Sadoul, Joanna Fombonne, Catherine Guix, Pierre-Antoine Bissey

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (26), pp.10510-5. ⟨10.1073/pnas.1200094109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (26), pp.10510-10515. ⟨10.1073/pnas.1200094109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (26), pp.10510-5. ⟨10.1073/pnas.1200094109⟩
Proceedings-National Academy of Sciences Usa
Proceedings-National Academy of Sciences Usa, 2012, 109 (26), pp.10510-5. 〈10.1073/pnas.1200094109〉

International audience; Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c8e0cced55fc3e03d17eca3081016e
https://doi.org/10.1073/pnas.1200094109