Zobrazeno 1 - 10
of 50
pro vyhledávání: '"MESH: Tryptophan"'
Autor:
Eleonora Latis, David Michonneau, Sivapriya Ramamoorthy, Gérard Socié, Sylvie Chevret, Emmanuel Curis, Régis Peffault de Latour, Brian J. Ingram, Lars Rogge, Laetitia Dubouchet, Flore Sicre de Fontbrune, Marie Robin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, 2019, 10 (1), pp.5695. ⟨10.1038/s41467-019-13498-3⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5695. ⟨10.1038/s41467-019-13498-3⟩
Nature Communications
Nature Communications, 2019, 10 (1), pp.5695. ⟨10.1038/s41467-019-13498-3⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5695. ⟨10.1038/s41467-019-13498-3⟩
Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). Recently, it has been demonstrated that the
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.2284. ⟨10.1038/s41467-022-29980-4⟩
Nature Communications, 2022, 13 (1), pp.2284. ⟨10.1038/s41467-022-29980-4⟩
2-iminoacetate synthase ThiH is a radical S-adenosyl-L-methionine (SAM) L-tyrosine lyase and catalyzes the L-tyrosine Cα–Cβ bond break to produce dehydroglycine and p-cresol while the radical SAM L-tryptophan lyase NosL cleaves the L-tryptophan C
Autor:
Ellen A. A. Nollen, Jasper Krijnen, Mariana Ruiz Silva, Rafael P. Vázquez-Manrique, R.C. Buijsman, Helen Michels, Annemieke T. van der Goot, Peter J. Oefner, Christian Neri, Renée I. Seinstra, Francesca Farina, Ronald Melki, Karen L. Thijssen, Wentao Zhu, Katja Dettmer, Ido P. Kema
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. ⟨10.1073/pnas.1203083109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. 〈10.1073/pnas.1203083109〉
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. ⟨10.1073/pnas.1203083109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. 〈10.1073/pnas.1203083109〉
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer’s diseases. Here, we identify tryptophan 2,3-dioxygenase ( tdo-2 ), the first enzyme in the kynu
Autor:
Céline Faux, Johan Wouters, Grégoire Rondelet, Véronique Masson, Paola B. Arimondo, Jean Dubois, Laurence Fleury, Luc Willems
Publikováno v:
Future Medicinal Chemistry
Future Medicinal Chemistry, Future Science, 2017, 9 (13), pp.1465-1481. ⟨10.4155/fmc-2017-0074⟩
Future Medicinal Chemistry, Future Science, 2017, 9 (13), pp.1465-1481. ⟨10.4155/fmc-2017-0074⟩
Aim: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activ
Publikováno v:
eNeuro
eNeuro, Society for Neuroscience, 2017, 4 (1), pp.ENEURO.0327-16.2017. ⟨10.1523/ENEURO.0327-16.2017⟩
eNeuro, 2017, 4 (1), pp.ENEURO.0327-16.2017. ⟨10.1523/ENEURO.0327-16.2017⟩
eNeuro, Society for Neuroscience, 2017, 4 (1), pp.ENEURO.0327-16.2017. ⟨10.1523/ENEURO.0327-16.2017⟩
eNeuro, 2017, 4 (1), pp.ENEURO.0327-16.2017. ⟨10.1523/ENEURO.0327-16.2017⟩
Visual Abstract
Serotonin (5-HT) neurotransmission in the brain relies on a widespread axon terminal network originating from the hindbrain raphe nuclei. These projections are topographically organized such that the dorsal (DR), and median raphe
Serotonin (5-HT) neurotransmission in the brain relies on a widespread axon terminal network originating from the hindbrain raphe nuclei. These projections are topographically organized such that the dorsal (DR), and median raphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a8e93c1510b31bfc406d98f436b19
https://hal.archives-ouvertes.fr/hal-02559482
https://hal.archives-ouvertes.fr/hal-02559482
Autor:
Wolfgang H. Oertel, Bertrand Friguet, Gesine Respondek, Günter U. Höglinger, Matthias Höllerhage, Agathe Tarze, Stefanie Müssner, Mohamed Salama, Christel Depienne, Agnès Rastetter, Anderson de Andrade, Pierre Champy, Elizabeth Sumi Yamada
Publikováno v:
Experimental neurology 253, 113-125 (2014). doi:10.1016/j.expneurol.2013.12.017
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
Experimental Neurology
Experimental Neurology, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Experimental Neurology, Elsevier, 2014, 253, pp.113-25. ⟨10.1016/j.expneurol.2013.12.017⟩
Web of Science
International audience; Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the ta
Autor:
Bruno Ragazzon, Isabelle Boutelet, Julien Wils, Marthe Rizk-Rabin, Estelle Louiset, Zakariae Bram, Marie-Christine Vantyghem, Rossella Libé, Sylvie Renouf, Constantine A. Stratakis, Eva Szarek, Céline Duparc, Dennis A. Carson, Antoine Martinez, Jacques Young, Hervé Lefebvre, Jérôme Bertherat
Publikováno v:
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), ⟨10.1172/jci.insight.87958⟩
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), ⟨10.1172/jci.insight.87958⟩
International audience; Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent hypercortisolism. The disease is primarily caused by germline mutations of the protein kinase A (PKA) regulatory subunit 1A (PRKAR1A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54122e209af72f6b75250a8b64f8281e
https://hal.archives-ouvertes.fr/hal-02108040
https://hal.archives-ouvertes.fr/hal-02108040
Autor:
Anna Wozniak, Ana Cristina Sotomayor Pérez, Bruno Baron, Johanna C. Karst, Patrick England, Daniel Ladant, Alexandre Chenal
Publikováno v:
Biophysical Journal
Biophysical Journal, 2010, 99 (11), pp.3744-53. ⟨10.1016/j.bpj.2010.10.016⟩
Biophysical Journal, Biophysical Society, 2010, 99 (11), pp.3744-53. ⟨10.1016/j.bpj.2010.10.016⟩
Biophysical Journal, 2010, 99 (11), pp.3744-53. ⟨10.1016/j.bpj.2010.10.016⟩
Biophysical Journal, Biophysical Society, 2010, 99 (11), pp.3744-53. ⟨10.1016/j.bpj.2010.10.016⟩
International audience; The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping cough. Its C-terminal region, the receptor-binding domain (RD), contains ∼40 calcium-binding R
Autor:
Romain R. Vivès, V. Garlatti, Christine Gaboriaud, Hugues Lortat-Jacob, Thomas Lunardi, Anne Chouquet, Gérard J. Arlaud, Helena Paidassi, Nicole M. Thielens
Publikováno v:
Journal of Immunology
Journal of Immunology, 2010, 185 (2), pp.808-12. ⟨10.4049/jimmunol.1000184⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (2), pp.808-12. ⟨10.4049/jimmunol.1000184⟩
Journal of Immunology, 2010, 185 (2), pp.808-12. ⟨10.4049/jimmunol.1000184⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (2), pp.808-12. ⟨10.4049/jimmunol.1000184⟩
C1q, the recognition subunit of the C1 complex of complement, is an archetypal pattern recognition molecule with the striking ability to sense a wide variety of targets, including a number of altered self-motifs. The recognition properties of its glo
Autor:
Elisabeth Le Rumeur, Jean-François Hubert, Serge Hardy, Christophe Tascon, Céline Raguénès-Nicol, Sébastien Legardinier, Chantal Rocher
Publikováno v:
Journal of Molecular Biology
Journal of Molecular Biology, 2009, 389 (3), pp.546-58. ⟨10.1016/j.jmb.2009.04.025⟩
BASE-Bielefeld Academic Search Engine
Journal of Molecular Biology, Elsevier, 2009, 389 (3), pp.546-58. ⟨10.1016/j.jmb.2009.04.025⟩
Journal of Molecular Biology, 2009, 389 (3), pp.546-58. ⟨10.1016/j.jmb.2009.04.025⟩
BASE-Bielefeld Academic Search Engine
Journal of Molecular Biology, Elsevier, 2009, 389 (3), pp.546-58. ⟨10.1016/j.jmb.2009.04.025⟩
International audience; Dystrophin is a cytoskeletal protein that confers resistance to the sarcolemma against the stress of contraction-relaxation cycles by interacting with cytoskeletal and membrane partners. Apart from several proteins, membrane p