Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors

Autor: Vogel, Christoph Franz Adam, Li, Wen, Wu, Dalei, Miller, Jamie K., Sweeney, Colleen, Lazennec, Gwendal, Fujisawa, Yasuko, Matsumura, Fumio

Publikováno v: Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩
Archives of Biochemistry and Biophysics, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩

International audience; The aryl hydrocarbon receptor (AhR) has been best known for its role in mediating the toxicity of dioxin. Here we show that AhR overexpression is found among estrogen receptor (ER)α-negative human breast tumors and that its o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::94569af0a499217ab51cee2046045d5f
https://hal.archives-ouvertes.fr/hal-03002191

Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males

Autor: Nathalie Gault, Thibaut Brugat, Jozo Delic, Jean-Brice Marteau, Hélène Merle-Béral, Torben F. Ørntoft, Sylvie Chevillard, Mogens Kruhøffer, Laurent Vallat, Odile Rigaud, Florence Nguyen-Khac

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, 2010, 3 (1), pp.53. ⟨10.1186/1755-8794-3-53⟩
Marteau, J-B, Rigaud, O, Brugat, T, Gault, N, Vallat, L, Kruhøffer, M, Ørntoft, T F, Nguyen-Khac, F, Chevillard, S, Merle-Beral, H & Delic, J 2010, ' Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males ', B M C Medical Genomics, vol. 3, pp. 53 . https://doi.org/10.1186/1755-8794-3-53
BMC Medical Genomics, Vol 3, Iss 1, p 53 (2010)
BMC Medical Genomics, BioMed Central, 2010, 3 (1), pp.53. ⟨10.1186/1755-8794-3-53⟩

Background The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both in vitro and in vivo, relies on their ability to activate apoptotic death. CLL cells resistant to DNA damage-induced apoptosis display deregulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da14432db9f96415ccb10fccfe0c06b
https://pubmed.ncbi.nlm.nih.gov/21062507

RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1

Autor: Wang, Xiaobo, Belguise, Karine, O'Neill, Christine F., Sánchez-Morgan, Nuria, Romagnoli, Mathilde, Eddy, Sean, Mineva, Nora, Yu, Ziyang, Min, Chengyin, Trinkaus- Randall, Vickery, Chalbos, Dany, Sonenshein, Gail

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2009, 29 (14), pp.3832-44. ⟨10.1128/MCB.00032-09⟩

International audience; Aberrant constitutive expression of NF-kappaB subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in tumorigenesis. Higher RelB subunit expression was demonstrated in estr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::de134b9d2825cefda89d99e57d8dc144
https://www.hal.inserm.fr/inserm-00396241/document

Aberrant rel/nfkb genes and activity in human cancer

Autor: Céline Gélinas, Béatrice Rayet

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 1999, 18 (49), pp.6938-6947. ⟨10.1038/sj.onc.1203221⟩

International audience; Rel/NF-kappaB transcription factors are key regulators of immune, inflammatory and acute phase responses and are also implicated in the control of cell proliferation and apoptosis. Remarkable progress has been made in understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5decf8fb4b493ab67c7a2d46d987ca
https://pubmed.ncbi.nlm.nih.gov/10602468