Výsledky vyhledávání - "MESH: Toll-Like Receptor 3"

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, 2015, 7 (1), pp.24-41. ⟨10.15252/emmm.201404459⟩
EMBO Molecular Medicine, Wiley Open Access, 2015, 7 (1), pp.24-41. ⟨10.15252/emmm.201404459⟩
ResearcherID

International audience; RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db6e773fcffe34e82b206a67160eb63

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TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Autor: Michel Pierres, Aicha Goubar, Laurence Zitvogel, Catherine Massacrier, Jean-Christophe Sabourin, Serge Lebecque, Rosa Conforti, Yannis Morel, Marie Pierre Chenard, Pedro Romero, Fabrice Andre, Bruno Salaun, Karine Chemin, Carine Asselin-Paturel, Clarisse Dubois, Donata Rimoldi

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2011, 71 (5), pp.1607-14. ⟨10.1158/0008-5472.CAN-10-3490⟩
Cancer Research, 2011, 71 (5), pp.1607-14. ⟨10.1158/0008-5472.CAN-10-3490⟩

The discovery of a targeted therapeutic compound along with its companion predictive biomarker is a major goal of clinical development for a personalized anticancer therapy to date. Here we present evidence of the predictive value of TLR3 expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aa9b292325bf3dfb8a75d446a14f1b
https://doi.org/10.1158/0008-5472.can-10-3490

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Inflammatory Regulation by TLR3 in Acute Hepatitis

Autor: Xiaoyan Xiao, Daniel Rodriguez-Pinto, Dake Qi, Richard A. Flavell, Peng Zhao, F. Susan Wong, Li Wen, Lena Alexopoulou, Octavian Henegariu

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 183 (6), pp.3712-9. ⟨10.4049/jimmunol.0901221⟩
Journal of Immunology, 2009, 183 (6), pp.3712-9. ⟨10.4049/jimmunol.0901221⟩

TLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrotic cells. Dying cells are a rich source of ligands that can activate TLRs, such as TLR3. TLR3 expressed in the liver is likely to be a mediator of innate activation and inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4d549e0a1450491be878e79ee3f538
https://doi.org/10.4049/jimmunol.0901221

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Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology

Autor: Christelle Faveeuw, Thierry Mallevaey, Virginie Vasseur, Bernhard Ryffel, Stanislas Goriely, François Vanhoutte, Claudia S. Zouain, François Trottein, Laetitia Breuilh, Monique Capron, Josette Fontaine

Publikováno v: Microbes and Infection
Microbes and Infection, Elsevier, 2007, 9 (14-15), pp.1606-13. ⟨10.1016/j.micinf.2007.09.013⟩

Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs) and in the induction of immune responses. However, relatively little is known about their functions in innate/acquired responses to comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e17cdfd82caee81cb369921c3cdcdc
https://doi.org/10.1016/j.micinf.2007.09.013

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[Prophylactic and therapeutic vaccination against human papillomavirus]

Autor: Brun , J.-L., Riethmuller , D.

Publikováno v: Journal de Gynécologie Obstétrique et Biologie de la Reproduction
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2007, 36 (7), pp.631-641. ⟨10.1016/j.jgyn.2007.06.005⟩
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2007, 36 (7), pp.631-641. 〈10.1016/j.jgyn.2007.06.005〉

International audience; Human papillomavirus is a necessary cause for the development of cervical cancer. Cervical cancer is attributed to 15 high-risk oncogenic HPV among the 120 genotypes present in human. The infection affects about 3 out of 4 wom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::93812c8d8742aee9c2342faf151fc6f6
https://hal.archives-ouvertes.fr/hal-00487262

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TLR3 deficiency in patients with herpes simplex encephalitis

Publikováno v: Science
Science, American Association for the Advancement of Science, 2007, 317 (5844), pp.1522-7. 〈10.1126/science.1139522〉
Science, American Association for the Advancement of Science, 2007, 317 (5844), pp.1522-7. ⟨10.1126/science.1139522⟩
Science, 2007, 317 (5844), pp.1522-7. ⟨10.1126/science.1139522⟩

International audience; Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac59fa332139e7bcc5477e3f0103b1a4
https://hal.archives-ouvertes.fr/hal-00297308

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Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression

Autor: Pierluigi Gasparini, Francesca Lovat, Nicola Zanesi, Carlo M. Croce, Roberta Galli, Hansjuerg Alder, Antonella Stoppacciaro, Paolo Fadda, Federica Calore, Alessio Paone, Anna Riccioli, Stefano Volinia, Luciano Cascione, Antonio Filippini, Mario Acunzo, Muller Fabbri, Andrea Tubaro, Elio Ziparo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (24), pp.9812-7. <10.1073/pnas.1304610110>
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (24), pp.9812-7. ⟨10.1073/pnas.1304610110⟩

Toll-like receptor 3 (TLR3) is a key effector of the innate immune system against viruses. Activation of TLR3 exerts an antitumoral effect through a mechanism of action still poorly understood. Here we show that TLR3 activation by polyinosinic:polycy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a466978f3e41af7514df3d141ee307cf
https://europepmc.org/articles/PMC3683754/

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Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells

Autor: Isabelle Meunier, Veronika von Messling, Emil Skamene, Silvia M. Vidal, Julien Pothlichet, Beckley K. Davis, Jenny P.-Y. Ting

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2013, 9 (4), pp.e1003256. ⟨10.1371/journal.ppat.1003256⟩
PLoS Pathogens, 2013, 9 (4), pp.e1003256. ⟨10.1371/journal.ppat.1003256⟩
PLoS Pathogens, Vol 9, Iss 4, p e1003256 (2013)

Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e623a7c939ed34510d241bfb594305c7
https://pubmed.ncbi.nlm.nih.gov/23592984

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Unexpected protective role for Toll-like receptor 3 in the arterial wall

Autor: Marc Feldmann, Lena Alexopoulou, Michael E. Goddard, Richard A. Flavell, T Navin, Claudia Monaco, Anuja T. Mitra, Alun H. Davies, Jennifer E. Cole, Amanda J. Cross

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (6), pp.2372-7. ⟨10.1073/pnas.1018515108⟩
Proceedings of the National Academy of Sciences; Vol 108
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (6), pp.2372-7. ⟨10.1073/pnas.1018515108⟩
Proceedings of the National Academy of Sciences

The critical role of Toll-like receptors (TLRs) in mammalian host defense has been extensively explored in recent years. The capacity of about 10 TLRs to recognize conserved patterns on many bacterial and viral pathogens is remarkable. With so few re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1853dbf5d6473cd360a4bc1f25080604
https://hal.science/hal-00609592

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TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA

Autor: Laurent Gauthier, Nathalie Bonnefoy-Berard, Mathieu Blery, Yannis Morel, Isabelle Durand, Ivan Perrot, Christophe Caux, Pierre Garrone, Lena Alexopoulou, Florence Deauvieau, Catherine Massacrier, Giorgio Trinchieri, Nicola Hughes, Nicolas Viaud, Jürg Tschopp, Carine Paturel, Olivier Demaria

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, vol. 185, no. 4, pp. 2080-2088

Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial. We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec534d69a148c97a95aff2c4a063369
https://hal.archives-ouvertes.fr/hal-00553598

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