TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

Autor: Jose Ursic-Bedoya, Isabelle Doignon, Hayat Simerabet, Dominique Rainteau, Doris Cassio, Nicolas Kahale, Anne Davit-Spraul, Thierry Tordjmann, Grégory Merlen, Lydie Humbert, Catherine Guettier, Julien Gautherot, Valeska Bidault-Jourdainne, Christoph Ullmer, Isabelle Garcin, Noémie Péan, Klaus Ebnet, Zahra Tanfin

Publikováno v: Gut
Gut, BMJ Publishing Group, 2019, 69 (1), pp.146-157. ⟨10.1136/gutjnl-2018-316975⟩
Gut, 2019, 69 (1), pp.146-157. ⟨10.1136/gutjnl-2018-316975⟩

ObjectiveWe explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability.DesignExperime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660294abb0fa3eb398b53de0626d479f
https://hal.umontpellier.fr/hal-03356970

Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines

Autor: Dubé, Evemie, Dufresne, Julie, Chan, Peter T K, Hermo, Louis, Cyr, Daniel G

Publikováno v: Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2010, 82 (6), pp.1119-28. ⟨10.1095/biolreprod.109.083196⟩

International audience; The epididymis is responsible for posttesticular sperm maturation. Sperm maturation is dependent on the luminal microenvironments along the epididymis. Though the role of the epididymis is well established, the molecular and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c410d296cd52a2bd6deae85b47b241fe
https://pubmed.ncbi.nlm.nih.gov/20164436