Výsledky vyhledávání - "MESH: Thyroid Hormone Receptors alpha"

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle

Autor: Xuguang Zhu, Rohit A. Sinha, Jia Pei Ho, Paul M. Yen, Cho Rong Han, Karine Gauthier, Sheue-yann Cheng, Andrea Lim, Jin Zhou

Publikováno v: Endocrinology
Endocrinology, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩
Endocrinology, Endocrine Society, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩

Skeletal muscle (SM) weakness occurs in hypothyroidism and resistance to thyroid hormone α (RTHα) syndrome. However, the cell signaling and molecular mechanism(s) underlying muscle weakness under these conditions is not well understood. We thus exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e473ccb3ae8d0e9b9d86e615b07c0215
https://hal.science/hal-03403597

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Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin

Autor: Romain Guyot, Jacques Samarut, Karine Gauthier, Frédéric Flamant, Wenyue Guan, Jiemin Wong

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (31), pp.8229-8234. ⟨10.1073/pnas.1702192114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (31), pp.8229-8234. ⟨10.1073/pnas.1702192114⟩

International audience; Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily that act as ligand-dependent transcription factors. Here we identified the ten-eleven translocation protein 3 (TET3) as a TR interacting p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf2b53766639fbc3f46a5f35c84cc8c
https://doi.org/10.1073/pnas.1702192114

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Metabolomic Profiling of Body Fluids in Mouse Models Demonstrates that Nuclear Magnetic Resonance Is a Putative Diagnostic Tool for the Presence of Thyroid Hormone Receptor α1 Mutations

Autor: Zekri, Yanis, Nicolaisen, Trine, Klein, Anders, Dmytriyeva, Oksana, Lund, Jens, Ingerslev, Lars, Fritzen, Andreas, Carl, Christian, Lundsgaard, Anne-Marie, Frost, Mikkel, Ma, Tao, Schjerling, Peter, Gerhart-Hines, Zachary, Larsen, Steen, Richter, Erik, Kiens, Bente, Clemmensen, Christoffer, Lundsgaard, Anne‐Marie, Gerhart‐Hines, Zachary, Warnich, L., Dietzsch, E., Heyns, D.A., Nicholson, D.L., Retief, A.E., Holbech, Henrik, Matthiessen, Peter, Hansen, Martin, Schüürmann, Gerrit, Knapen, Dries, Reuver, Marieke, Sachs, Laurent, Kloas, Werner, Hilscherova, Klara, Leonard, Marc, Arning, Jürgen, Strauss, Volker, Iguchi, Taisen, Baumann, Lisa, Richard, Sabine, Guyot, Romain, Rey-Millet, Martin, Prieux, Margaux, Aubert, Denise, BOUMAZA, Houda, Markossian, Suzy, Busi, Baptiste, Rautureau, Gilles, Gauthier, Karine, Elena-Herrmann, Bénédicte, Flamant, Frederic, Rautureau, Gilles J.P.

Publikováno v: Thyroid
Thyroid, Mary Ann Liebert, 2019, 29 (9), pp.1327-1335. ⟨10.1089/thy.2018.0730⟩
Thyroid, 2019, 29 (9), pp.1327-1335. ⟨10.1089/thy.2018.0730⟩

International audience; Background: Resistance to thyroid hormone alpha (RTH alpha) is a rare genetic disease due to mutations in the THRA gene, which encodes thyroid hormone receptor alpha 1 (TR alpha 1). Since its first description in 2012, 46 case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0692ccd53c8c5663444f816f3f4d22a7
https://hal.inrae.fr/hal-02996883

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Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour

Autor: O. Dkhissi-Benyahya, Sabine Richard, Frédéric Flamant, Nadine Aguilera, Marc Thevenet

Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2017, 321, pp.18-27. ⟨10.1016/j.bbr.2016.12.025⟩
Behavioural Brain Research, 2017, 321, pp.18-27. ⟨10.1016/j.bbr.2016.12.025⟩

International audience; In humans, alterations in thyroid hormone signalling are associated with mood and anxiety disorders, but the neural mechanisms underlying such association are poorly understood. The present study investigates the involvement o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4980db8fe7e7654533b6d2ff19b82c
https://hal.inrae.fr/hal-02619105

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TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone

Autor: Frédéric Flamant, Jean-Louis Wémeau, Stéphanie Espiard, Virginie Vlaeminck-Guillem

Publikováno v: La Presse Médicale
La Presse Médicale, Elsevier Masson, 2015, 44 (11), pp.1103-1112. ⟨10.1016/j.lpm.2015.07.022⟩
La Presse Médicale, 2015, 44 (11), pp.1103-1112. ⟨10.1016/j.lpm.2015.07.022⟩

International audience; Since 2012, eight different abnormalities have been described in the THRA gene (encoding the TRα1 thyroid hormone receptor) of 14 patients from 9 families. These mutations induce a clinical phenotype (resistance to thyroid ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d0d3058ba479d4873b896d4f7460c9
https://pubmed.ncbi.nlm.nih.gov/26615083

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Nongenomic, TRβ-Dependent, Thyroid Hormone Response Gets Genetic Support

Autor: Chatonnet, Fabrice, Livera, Gabriel, Fumel, Betty, Fouchécourt, Sophie, Gauthier, Karine, Flamant, Frederic

Publikováno v: Endocrinology
Endocrinology, 2014, 155 (9), pp.3206-3209. ⟨10.1210/en.2014-1597⟩
Endocrinology, Endocrine Society, 2014, 155 (9), pp.3206-3209. ⟨10.1210/en.2014-1597⟩

In his famous 1962 book, The Structure of Scientific Revolutions, Thomas Kuhn observed that scientific fields undergo periodic paradigm shifts, which open up new approaches to understanding that would never have been considered valid before. For exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa9fa2a9d94525ab70f0bd530ff6daa
https://hal.science/hal-03278412

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Minireview: Deciphering Direct and Indirect Influence of Thyroid Hormone With Mouse Genetics

Autor: Aguilera, N., Thévenet, M., Dkhissi-Benyahya, O., Picou, Frédéric, Fauquier, Teddy, Chatonnet, Fabrice, Richard, Sabine, Flamant, Frederic

Publikováno v: Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 2014, 28 (4), pp.429-441. ⟨10.1210/me.2013-1414⟩
Molecular Endocrinology
Molecular Endocrinology, 2014, 28 (4), pp.429-441. ⟨10.1210/me.2013-1414⟩

International audience; T3, the active form of thyroid hormone, binds nuclear receptors that regulate the transcription of a large number of genes in many cell types. Unraveling the direct and indirect effect of this hormonal stimulation, and establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820bd12aa3921e47295697533dc37c53
https://hal.archives-ouvertes.fr/hal-02164763

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Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development

Autor: Fabrice Chatonnet, Nicolas Fossat, Thomas Lamonerie, Frederic Picou, Frédéric Flamant, Sabine Richard, Teddy Fauquier, Nadine Aguilera

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2013, 141 (1), pp.166-175. ⟨10.1242/dev.103226⟩
Development (Cambridge, England), Company of Biologists, 2014, 141 (1), pp.166-75. ⟨10.1242/dev.103226⟩

International audience; Thyroid hormone is necessary for normal development of the central nervous system, as shown by the severe mental retardation syndrome affecting hypothyroid patients with low levels of active thyroid hormone. The postnatal defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d1e9b4d8c9d4f38165dada88b5a52
https://pubmed.ncbi.nlm.nih.gov/24346699

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Thyroid hormone receptor alpha plays an essential role in the normalisation of adult-onset hypothyroidism-related hypoexpression of synaptic plasticity target genes in striatum

Autor: Paul Higueret, Olivier Chassande, V Enderlin, Julie Vallortigara

Publikováno v: Journal of Neuroendocrinology
Journal of Neuroendocrinology, Wiley, 2009, 21 (1), pp.49-56. ⟨10.1111/j.1365-2826.2008.01802.x⟩

Thyroid hormones (TH), particularly thyroxine (T4) and triiodothyro-nine (3,5,3¢-triiodothyronine, T3), are known to have pleiotrophiceffects in various tissues, including brain, liver, heart, kidney, lung,bone and adipose tissue. The brain is an im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7620b02116367e4c028c1d769bbb5cbe
https://pubmed.ncbi.nlm.nih.gov/19094093

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