Výsledky vyhledávání - "MESH: Thrombin"

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Autor: Marie Octave, Laurence Pirotton, Audrey Ginion, Valentine Robaux, Sophie Lepropre, Jérôme Ambroise, Caroline Bouzin, Bruno Guigas, Martin Giera, Marc Foretz, Luc Bertrand, Christophe Beauloye, Sandrine Horman

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (23), pp.13129. ⟨10.3390/ijms222313129⟩
International Journal of Molecular Sciences, 22(23). MDPI
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13129
International Journal of Molecular Sciences, Vol 22, Iss 13129, p 13129 (2021)
International journal of molecular sciences, Vol. 22, no. 23, p. 13129 [1-17] (2021)

International audience; Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the ace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d460f33aa769cd4b3b498816c1247
https://doi.org/10.3390/ijms222313129

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High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions

Autor: Philippe Champeil, Pierre Le Maréchal, Joseph A. Lyons, Poul Nissen, José Luis Vázquez-Ibar, Cédric Montigny, Aurore Jacquot, Thibaud Dieudonné, Jakob Ulstrup, Miriam-Rose Ash, Guillaume Lenoir, Hassina Azouaoui

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (19), pp.7954-7970. ⟨10.1074/jbc.M116.751487⟩
Journal of Biological Chemistry, 2017, 292 (19), pp.7954-7970. ⟨10.1074/jbc.M116.751487⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (19), pp.7954-7970. 〈10.1074/jbc.M116.751487〉
Azouaoui, H, Montigny, C, Dieudonné, T, Champeil, P, Jacquot, A, Vázquez-Ibar, J L, le Maréchal, P, Ulstrup, J, Ash, M-R, Lyons, J A, Nissen, P & Lenoir, G 2017, ' A High and Phosphatidylinositol-4-phosphate (PI4P)-dependent ATPase Activity for the Drs2p/Cdc50p Flippase after Removal of its N-and C-terminal Extensions ', Journal of Biological Chemistry, vol. 292, pp. 7954-7970 . https://doi.org/10.1074/jbc.M116.751487

International audience; P4-ATPases, also known as phospholipid flippases, are responsible for creating and maintaining transbilayer lipid asymmetry in eukaryotic cell membranes. Here, we use limited proteolysis to investigate the role of the N and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a13bfa67cbd26904683eacf27edde2
https://hal.archives-ouvertes.fr/hal-01697714

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Modelling ligand selectivity of serine proteases using integrative proteochemometric approaches improves model performance and allows the multi-target dependent interpretation of features

Autor: Andreas Bender, Oscar Méndez-Lucio, Qurrat ul Ain, Thérèse E. Malliavin, Isidro Cortes Ciriano, Gerard J. P. van Westen

Publikováno v: Integrative Biology, 6(11), 1023-1033
Integrative biology
Integrative biology, Royal Society of Chemistry, 2014, 6 (11), pp.1023-1033. ⟨10.1039/C4IB00175C⟩
Integrative biology, 2014, 6 (11), pp.1023-1033. ⟨10.1039/C4IB00175C⟩

International audience; Serine proteases, implicated in important physiological functions, have a high intra-family similarity, which leads to unwanted off-target effects of inhibitors with insufficient selectivity. However, the availability of seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21869922e9275eaa5da1a64e4f0f956
https://doi.org/10.1039/c4ib00175c

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Fondaparinux reversal with activated prothrombin complex concentrate in anesthetised bleeding rats

Autor: G. Corbonnois, Marie Hacquard, Michèle Martin, Bruno Levy, Gérard Audibert, Thomas Lecompte, Paul-Michel Mertes

Publikováno v: Thrombosis and Haemostasis
Thrombosis and Haemostasis, Schattauer, 2013, 109 (3), pp.560-563. ⟨10.1160/TH12-08-0575⟩

Fondaparinux reversal with activated prothrombin complex concentrate in anesthetised bleeding rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89549a8f66cca6ee02c5993a5fcaf3
https://doi.org/10.1160/th12-08-0575

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Diet Modulates Endogenous Thrombin Generation, A Biological Estimate of Thrombosis Risk, Independently of the Metabolic Status

Autor: C. Sanchez, Marjorie Poggi, Stéphane Tanguy, Pierre-Emmanuel Morange, Michel Grino, Jean-Charles Martin, Anne Dutour, Marie-Christine Alessi, Catherine Defoort

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32 (10), pp.2394-404. ⟨10.1161/ATVBAHA.112.250332⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (10), pp.2394-404. ⟨10.1161/ATVBAHA.112.250332⟩

Objective— High endogenous thrombin potential (ETP) is associated with venous and arterial thrombosis. Better knowledge of environmental influences on ETP may help to prevent thrombosis. Methods and Results— Weaning rats exhibited high ETP values

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20da49ab6facd1b8ff091b36c79fd455
https://doi.org/10.1161/atvbaha.112.250332

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Antithrombin-Independent Effects of Heparins on Fibrin Clot Nanostructure

Autor: Christelle Yeromonahos, Raphaël Marlu, Benoît Polack, François Caton

Publikováno v: Europe PubMed Central
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (5), pp.1320-4. ⟨10.1161/ATVBAHA.112.245308⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (5), pp.1320-1324. ⟨10.1161/ATVBAHA.112.245308⟩

Objective— Because of the widespread clinical use of heparins, their effects on the enzymatic cascade are very well known. In contrast, little is known about the direct effect of heparins on the nanostructure of fibrin fibers, even though this nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ecb86e08d213adb997823a28adebf3
https://doi.org/10.1161/atvbaha.112.245308

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Platelet type III collagen binding protein (TIIICBP) presents high biochemical and functional similarities with kindlin-3

Autor: Françoise Fauvel-Lafève, Valérie Labas, Samia Mourah, Joëlle Vinh, Monique Lemesle, Chantal Legrand, Ibtissem Djaafri, Pascal Maurice, Brigitte Arbeille

Publikováno v: Biochimie
Biochimie, Elsevier, 2012, 94 (2), pp.416-426. ⟨10.1016/j.biochi.2011.08.009⟩
Biochimie, Elsevier, 2012, 94 (2), pp.416-26. ⟨10.1016/j.biochi.2011.08.009⟩

International audience; Type III collagen binding protein (TIIICBP) was previously described as a platelet membrane protein that recognizes the KOGEOGPK peptide sequence within type III collagen. In order to better characterize this protein, we perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51f5d55a560d824409b844b8f933108
https://doi.org/10.1016/j.biochi.2011.08.009

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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis

Autor: Anne Rullier, Nathalie Dugot-Senant, Jean Rosenbaum, Jennifer Gillibert-Duplantier, Gérard Déléris, Cyril Petibois, Pierre Costet, Gaelle Cubel, Valérie Haurie, Paulette Bioulac-Sage, Danièle Taras

Publikováno v: AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, 2008, 294 (1), pp.G226-35. ⟨10.1152/ajpgi.00444.2007⟩

Thrombin inhibition protects against liver fibrosis. However, it is not known whether the thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease-activated receptors (PARs). We took advantage of the lack of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d43669519b81c8d6853c718c7987ecf
https://doi.org/10.1152/ajpgi.00444.2007

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Real-Time Analysis of Agonist-Induced Activation of Protease-Activated Receptor 1/Gαi1Protein Complex Measured by Bioluminescence Resonance Energy Transfer in Living Cells

Autor: Damien Maurel, Michel Fink, Mohammed Akli Ayoub, Laurent Prézeau, Virginie Binet, Hervé Ansanay, Jean-Philippe Pin

Publikováno v: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (5), pp.1329-40. ⟨10.1124/mol.106.030304⟩

G protein-coupled receptors transmit extracellular signals into the cells by activating heterotrimeric G proteins, a process that is often followed by receptor desensitization. Monitoring such a process in real time and in living cells will help bett

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdcd45c6627b36ca2e1aafaf7e12e41
https://doi.org/10.1124/mol.106.030304

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