mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Autor: Martin, Pierre-Yves, Doly, Stéphane, Hamieh, Al Mahdy, Chapuy, Eric, Canale, Vittorio, Drop, Marcin, Chaumont-Dubel, Séverine, Bantreil, Xavier, Lamaty, Frédéric, Bojarski, Andrzej, Zajdel, Pawel, Eschalier, Alain, Marin, Philippe, COURTEIX, Christine

Publikováno v: Progress in Neurobiology
Progress in Neurobiology, Elsevier, 2020, 193, pp.101846. ⟨10.1016/j.pneurobio.2020.101846⟩
Progress in Neurobiology, 2020, 193, pp.101846. ⟨10.1016/j.pneurobio.2020.101846⟩

International audience; Chronic neuropathic pain is a highly disabling syndrome that is poorly controlled by currently available analgesics. Here, we show that painful symptoms and associated cognitive deficits induced by spinal nerve ligation in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8aef17b38cdcef4604d7c319d906c1cb
https://hal.uca.fr/hal-02906397/document

p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth

Autor: Ada Nowosad, Caroline Callot, Carine Joffre, Arnaud Besson, Stéphane Manenti, Patrice Codogno, Pauline Jeannot, Justine Creff, Renaud T. Perchey

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (9), pp.1076-1090. ⟨10.1038/s41556-020-0554-4⟩

International audience; Autophagy is a catabolic process whereby cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis during nutrient depletion. Several studies reported that the CDK inhibitor p27Kip1 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94e1a946c85d0a3567d7dd5c51cec58
https://hal.archives-ouvertes.fr/hal-02989025

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

Autor: Samuel T Workenhe, Akiko Yanagiya, Huy-Dung Hoang, Soroush Tahmasebi, Dana Pearl, Adrian Pelin, John C. Bell, Chadi Zakaria, Karen L. Mossman, Tyson E. Graber, Jaclyn Hearnden, Polen Sean, Tommy Alain, Jian-Jun Jia, Margaret Watson, Louis-Phillipe Leroux, Seyed Mehdi Jafarnejad, Jean-Simon Diallo, Nahum Sonenberg, Maritza Jaramillo, Nathaniel Robichaud, Vinh Tai Truong, Fabrice Le Boeuf

Publikováno v: Zakaria, C, Sean, P, Hoang, H-D, Leroux, L-P, Watson, M, Workenhe, S T, Hearnden, J, Pearl, D, Truong, V T, Robichaud, N, Yanagiya, A, Tahmasebi, S, Jafarnejad, S M, Jia, J-J, Pelin, A, Diallo, J-S, Le Boeuf, F, Bell, J C, Mossman, K L, Graber, T E, Jaramillo, M, Sonenberg, N & Alain, T 2018, ' Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis ', PLoS Pathogens, vol. 14, no. 8, e1007264 . https://doi.org/10.1371/journal.ppat.1007264
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007264. ⟨10.1371/journal.ppat.1007264⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007264 (2018)

International audience; Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c92dee5a0216e1929b4920ce8f0aa3
https://pubmed.ncbi.nlm.nih.gov/30138450

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

Autor: Julie Lorent, Maritza Jaramillo, Laia Masvidal, Tommy Alain, Ola Larsson, Visnu Chaparro, Bruno D. Fonseca, Tyson E. Graber, Léon C van Kempen, Maria Aguirre, Louis-Philippe Leroux

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2018, 86 (9), pp.e00244-18. ⟨10.1128/IAI.00244-18⟩
Infection and Immunity, 86(9):ARTN e00244-18. AMER SOC MICROBIOLOGY

International audience; The intracellular parasite Toxoplasma gondii promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ebb9a78a49ce9a9e41a7e1dacffad
https://doi.org/10.1128/iai.00244-18

Signalling pathways regulating muscle mass in ageing skeletal muscle

Autor: Luana Toniolo, L. Barberi, Astrid Y. Bijlsma, Antonio L. Serrano, Carel G. M. Meskers, Lars Larsson, Mario Pende, Rosario Rizzuto, Marco Sandri, Kenneth A. Dyar, Cristina Mammucari, Andrea B. Maier, Giorgia Pallafacchina, M. Roceri, Pura Muñoz-Cánoves, Stefano Schiaffino, Antonio Paoli, D. Pion, Giulia Milan, Bert Blaauw, Antonio Musarò, Carlo Reggiani, Vanina Romanello

Publikováno v: Biogerontology, 14(3), 303-23. Springer Netherlands
Biogerontology
Biogerontology, Springer Verlag, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology; Vol 14
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Munoz-Canoves, P, Musaro, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-323 . https://doi.org/10.1007/s10522-013-9432-9
Biogerontology, 2013, 14 (3), pp.303-23. ⟨10.1007/s10522-013-9432-9⟩
Biogerontology, 14(3), 303-323. Springer Netherlands
Biogerontology, 14(3), 303-323
Sandri, M, Barberi, L, Bijlsma, A Y, Blaauw, B, Dyar, K A, Milan, G, Mammucari, C, Meskers, C G M, Pallafacchina, G, Paoli, A, Pion, D, Roceri, M, Romanello, V, Serrano, A L, Toniolo, L, Larsson, L, Maier, A B, Muñoz-Cánoves, P, Musarò, A, Pende, M, Reggiani, C, Rizzuto, R & Schiaffino, S 2013, ' Signalling pathways regulating muscle mass in ageing skeletal muscle : the role of the IGF1-Akt-mTOR-FoxO pathway ', Biogerontology, vol. 14, no. 3, pp. 303-23 . https://doi.org/10.1007/s10522-013-9432-9

International audience; During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle mass and force and a major cause of physical frailty. To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f4a5d65f36ee74ba4de2ecd531c858
https://hdl.handle.net/1871.1/c3edf814-3c90-4667-8713-c3a120aff07a