Expansion of Interleukin‐22– and Granulocyte–Macrophage Colony‐Stimulating Factor–Expressing, but Not Interleukin‐17A–Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

Autor: Sijia Chen, Leonike J. J. van Mens, S. Menegatti, Hergen Spits, Dominique Baeten, Lars Rogge, Talia E. Latuhihin, Hulda S. Hreggvidsdottir, Iris C Blijdorp, Troy Noordenbos, Nataliya Yeremenko, Marleen G H van de Sande, Jochem H. Bernink

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & rheumatology (Hoboken, N.J.), 71(3), 392-402. John Wiley and Sons Ltd
Arthritis & rheumatology
Arthritis & rheumatology, 2019, 71 (3), pp.392-402. ⟨10.1002/art.40736⟩
Arthritis & rheumatology, Wiley, 2019, 71 (3), pp.392-402. ⟨10.1002/art.40736⟩

International audience; Objective: Clinical trials of the anti-interleukin-17A (anti-IL-17A) antibody secukinumab have demonstrated a crucial role of the cytokine IL-17A in the pathogenesis of spondyloarthritis (SpA); however, its cellular source in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7061c080fd7bb1563260905d5b4100
https://doi.org/10.1002/art.40736

Number of individual ACPA reactivities in synovial fluid immune complexes, but not serum anti-CCP2 levels, associate with inflammation and joint destruction in rheumatoid arthritis

Autor: Sohrabian, Azita, Mathsson-Alm, Linda, Hansson, Monika, Knight, Ann, Lysholm, Jörgen, Cornillet, Martin, Skriner, Karl, Serre, Guy, Larsson, Anders, Weitoft, Tomas, Rönnelid, Johan

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2018, 77 (9), pp.1345-1353. ⟨10.1136/annrheumdis-2017-212627⟩
Annals of the Rheumatic Diseases, 2018, 77 (9), pp.1345-1353. ⟨10.1136/annrheumdis-2017-212627⟩

International audience; Introduction : Individual patients with rheumatoid arthritis (RA) show divergent specific anti-citrullinated protein/peptide antibodies (ACPA) patterns, but hitherto no individual ACPA specificity has consistently been linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c27ebf3268a51c442bca834a14a79da
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363389

Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients

Autor: Jérôme Amiaud, Céline Cozic, Martine Berreur, M Chemel, Franck Verrecchia, Gwenola Bougras, B. Le Goff, M.-F. Heymann, J M Berthelot, S Touchais, Dominique Heymann, Frédéric Blanchard, Régis Brion

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2012, 71 (1), pp.150-4. ⟨10.1136/annrheumdis-2011-200096⟩

ObjectivesInterleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA).MethodsImmunohistochemistry was performed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35029a9d492032a703dd887d5f61b19e
https://www.hal.inserm.fr/inserm-00667486

Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients

Autor: Jean-Pierre Cedoz, Daniel Wendling, Evelyne Racadot

Publikováno v: Clinical Rheumatology
Clinical Rheumatology, Springer Verlag, 2009, 28 (2), pp.187-90. ⟨10.1007/s10067-008-1011-0⟩

International audience; IL-23 is the main inductor in Th17 polarization of naive T cells, inducing IL-17 production. IL-17 has been demonstrated to be elevated in ankylosing spondylitis (AS). The p40 subunit is common to IL-12 and IL-23. We assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0230eff90ce482cdb69fc7532cb28c8
https://pubmed.ncbi.nlm.nih.gov/18827961

A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis

Autor: Nathalie, Simard, Gilles, Boire, Artur J, de Brum-Fernandes, Yves, St-Pierre

Publikováno v: Arthritis Research and Therapy
Arthritis Research and Therapy, BioMed Central, 2006, 8 (4), pp.R125. ⟨10.1186/ar2014⟩
Arthritis Research & Therapy

International audience; Despite decades of research, only a very limited number of matrix metalloproteinase (MMP) inhibitors have been successful in clinical trials of arthritis. One of the central problems associated with this failure may be our ina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::70c06a5ae8c192e13d42f473dd784a05
https://hal-riip.archives-ouvertes.fr/pasteur-00820005