Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS

Autor: Phillip C. Wong, Diana Wiesner, Francesco Roselli, Tobias M. Boeckers, Deniz Yilmazer-Hanke, Barbara Commisso, Linyun Tang, Albert C. Ludolph, Jochen H. Weishaupt, Najwa Ouali Alami, Luc Dupuis, David Bayer, Bernd Baumann, Thomas Wirth

Publikováno v: Life science alliance 3(11), e201900571 (2020). doi:10.26508/lsa.201900571
Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩

Chemogenetic motoneuron excitation and astrocyte GPCR-Gi signaling restore blood–spinal cord barrier, disrupted in four ALS mouse models, revealing its role in disease progression but not initiation.
Blood–spinal cord barrier (BSCB) disrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93218dfe1100975b7bc1fb24ea761df4
https://pub.dzne.de/record/164314

Development of a PCR algorithm to detect and characterize Neisseria meningitidis carriage isolates in the African meningitis belt

Autor: Diallo, K, Coulibaly, MD, Rebbetts, LS, Harrison, OB, Lucidarme, J, Gamougam, K, Tekletsion, YK, Bugri, A, Toure, A, Issaka, B, Dieng, M, Trotter, C, Collard, JM, Sow, SO, Wang, X, Mayer, LW, Borrow, R, Greenwood, BM, Maiden, MCJ, Manigart, O

Publikováno v: Diallo, K, Coulibaly, M D, Rebbetts, L S, Harrison, O B, Lucidarme, J, Gamougam, K, Tekletsion, Y, Bugri, A, Toure, A, Issaka, B, Dieng, M, Trotter, C L, Collard, J M, Sow, S O, Wang, X, Mayer, L W, Borrow, R, Greenwood, B M, Maiden, M C, Manigart, O 2018, ' Development of a PCR algorithm to detect and characterize Neisseria meningitidis carriage isolates in the African meningitis belt ', PLoS ONE, vol. 13, no. 12, e0206453 . https://doi.org/10.1371/journal.pone.0206453
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (12), pp.e0206453. ⟨10.1371/journal.pone.0206453⟩
PLoS ONE, 2018, 13 (12), pp.e0206453. ⟨10.1371/journal.pone.0206453⟩

International audience; Improved methods for the detection and characterization of carried Neisseria meningitidis isolates are needed. We evaluated a multiplex PCR algorithm for the detection of a variety of carriage strains in the meningitis belt. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c678d5680ff88b563e0c86b01c357770
http://ora.ox.ac.uk/objects/uuid:

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

Autor: Henriques, Alexandre, Huebecker, Mylene, Blasco, Hélène, Keime, Céline, Andres, Christian, Corcia, Philippe, Priestman, David, Platt, Frances, Spedding, Michael, Loeffler, Jean-Philippe

Publikováno v: Scientific Reports
Scientific Reports, 2017, 7 (1), pp.5235. ⟨10.1038/s41598-017-05313-0⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.5235. ⟨10.1038/s41598-017-05313-0⟩

International audience; Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and glucosylceramide, to neurodegeneration and to motor unit dismantling in amyotrophic lateral sclerosis at late disease stage. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::203e5fa75b09fea7e92e9f3f5ea4e75b
https://www.hal.inserm.fr/inserm-03375219

The chemokine CCL2 protects against methylmercury neurotoxicity.: chemokines and methymercury neurotoxicity

Autor: Jean-Paul Bourdineaud, Romain-Daniel Gosselin, Stéphane Mélik-Parsadaniantz, Randeep Rakwal, Muriel Laclau, William Rostène, Akira Yasutake, David Godefroy, Régine Maury-Brachet, Christophe Combadière, Masatake Fujimura

Publikováno v: Toxicological Sciences, vol. 125, no. 1, pp. 209-218
Review of Economic Dynamics
Review of Economic Dynamics, 2012, 125 (1), pp.209-18. ⟨10.1093/toxsci/kfr252⟩
Review of Economic Dynamics, Elsevier, 2012, 125 (1), pp.209-18. ⟨10.1093/toxsci/kfr252⟩

10, 5 figures, 3 tables, 1 suppl figure and 1 suppl table; International audience; Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216c6718ad5a68d2e915f60517ad6896
https://doi.org/10.1093/toxsci/kfr252

Do Genetic Variations in Antioxidant Enzymes Influence the Course of Hereditary Hemochromatosis?

Autor: Pierre Rufat, Jean-Claude Trinchet, Michel Beaugrand, Yves Deugnier, Dominique Pessayre, Angela Sutton, Nathalie Charnaux, Pierre Nahon

Publikováno v: Antioxidants and Redox Signaling
Antioxidants and Redox Signaling, Mary Ann Liebert, 2011, 15 (1), pp.31-8. ⟨10.1089/ars.2010.3529⟩
Antioxidants and Redox Signaling, 2011, 15 (1), pp.31-8. ⟨10.1089/ars.2010.3529⟩

International audience; Iron-induced oxidative stress promotes hepatic injury in hereditary hemochromatosis, which can be influenced by genetic traits affecting antioxidant enzymes. We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfff37571cfd70b7189a12b783fdd51e
https://doi.org/10.1089/ars.2010.3529