Exercise-Induced Activation of NMDA Receptor Promotes Motor Unit Development and Survival in a Type 2 Spinal Muscular Atrophy Model Mouse

Autor: Hung Li, Philippe Lopes, Sylvie Lécolle, Séverine Deforges, Carmen Cifuentes-Diaz, Bruno Della Gaspera, Frédéric Charbonnier, Christophe Chanoine, Clément Grondard, Claude Pariset, Olivier Biondi

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2008, 28 (4), pp.953-62. ⟨10.1523/JNEUROSCI.3237-07.2008⟩
Journal of Neuroscience, Society for Neuroscience, 2008, 28 (4), pp.953-62. <10.1523/JNEUROSCI.3237-07.2008>

Spinal muscular atrophy (SMA) is an inborn neuromuscular disorder caused by low levels of survival motor neuron protein, and for which no efficient therapy exists. Here, we show that the slower rate of postnatal motor-unit maturation observed in type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1319a1cf6bbf0eca938087e589393c25
https://doi.org/10.1523/jneurosci.3237-07.2008