Výsledky vyhledávání - "MESH: Spectrin"

Spectrin binding motifs regulate Scribble cortical dynamics and polarity function

Autor: Batiste Boëda, Sandrine Etienne-Manneville

Publikováno v: eLife
eLife, 2015, 4, pp.e04726. ⟨10.7554/eLife.04726⟩
eLife, eLife Sciences Publication, 2015, 4, pp.e04726. ⟨10.7554/eLife.04726⟩
eLife, Vol 4 (2015)

The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood. Here we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77304e38dab38e71ff8bee3fd9c6a2bb
https://hal-pasteur.archives-ouvertes.fr/pasteur-02059119

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Pathways and Intermediates in Forced Unfolding of Spectrin Repeats

Autor: Pierre-François Lenne, Stephan M. Altmann, Arnt J. Raae, Kristina M. Herbert, Raik Grünberg, Matti Saraste, Michael Nilges, Jari Ylänne, J. K. Heinrich Hörber

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2002, 10, pp.1085. ⟨10.1016/S0969-2126(02)00808-0⟩
ResearcherID
Structure, 2002, 10, pp.1085. ⟨10.1016/S0969-2126(02)00808-0⟩

International audience; Spectrin repeats are triple-helical coiled-coil domains found in many proteins that are regularly subjected to mechanical stress. We used atomic force microscopy technique and steered molecular dynamics simulations to study th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c624b4ed0c1cc073765e8832be4d22
https://doi.org/10.1016/s0969-2126(02)00808-0

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Novel Mutation in Spectrin-like Repeat 1 of Dystrophin Central Domain Causes Protein Misfolding and Mild Becker Muscular Dystrophy*

Autor: Mohammad El-Baba, Olivier Delalande, William J. Kupsky, Angélique Chéron, Jean-François Hubert, Gyula Acsadi, Steven A. Moore, Lindsey Bennett, Elisabeth Le Rumeur

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2012, 287 (22), pp.18153-62. ⟨10.1074/jbc.M111.284521⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (22), pp.18153-62. ⟨10.1074/jbc.M111.284521⟩

International audience; Mutations in the dystrophin gene without disruption of the reading frame often lead to Becker muscular dystrophy, but a genotype/phenotype correlation is difficult to establish. Amino acid substitutions may disrupt binding cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efff6cedc4d443cd0407f62a965abe11
https://europepmc.org/articles/PMC3365720/

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Apico-basal elongation requires a drebrin-E-EB3 complex in columnar human epithelial cells

Autor: Elsa Bazellières, Dominique Massey-Harroche, André Le Bivic, Magali Barthélémy-Requin, Fabrice Richard, Jean-Pierre Arsanto

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2012, 125 (Pt 4), pp.919-31. ⟨10.1242/jcs.092676⟩
Journal of Cell Science, 2012, 125 (Pt 4), pp.919-31. ⟨10.1242/jcs.092676⟩

International audience; Although columnar epithelial cells are known to acquire an elongated shape, the mechanisms involved in this morphological feature have not yet been completely elucidated. Using columnar human intestinal Caco2 cells, it was est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e92d3ebb42021e2e8e0b1419e072d6a
https://hal.archives-ouvertes.fr/hal-00843390

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Spectrin-like repeats 11-15 of human dystrophin show adaptations to a lipidic environment

Autor: Joe Sarkis, Elisabeth Le Rumeur, Julien Jardin, Estelle Robert, Jean-François Hubert, Angélique Chéron, Véronique Vié, Eric Hitti, Baptiste Legrand

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (35), pp.30481-91. ⟨10.1074/jbc.M111.243881⟩
Journal of Biological Chemistry, 2011, 286 (35), pp.30481-91. ⟨10.1074/jbc.M111.243881⟩
Journal of Biological Chemistry 35 (286), 30481-30491. (2011)

International audience; Dystrophin is essential to skeletal muscle function and confers resistance to the sarcolemma by interacting with cytoskeleton and membrane. In the present work, we characterized the behavior of dystrophin 11-15 (DYS R11-15), f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1838b6fd4c17532cb06ca0f384441d0d
https://pubmed.ncbi.nlm.nih.gov/21712383

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The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier

Autor: Devaux, Jérôme J

Publikováno v: The Journal of Physiology
The Journal of Physiology, Wiley, 2010, 588 (Pt 23), pp.4719-30. ⟨10.1113/jphysiol.2010.196022⟩
The Journal of Physiology, 2010, 588 (Pt 23), pp.4719-30. ⟨10.1113/jphysiol.2010.196022⟩

International audience; The spectrin cytoskeleton has an important function in the targeting of proteins to excitable membrane domains. In axons, βIV-spectrin stabilizes voltage-gated sodium (Nav) channel clusters at nodes of Ranvier and axon initia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aa49f0ced661561d3e0972a452fab94a
https://hal.archives-ouvertes.fr/hal-00625232

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Red blood cell polymorphisms in beta degrees-39 heterozygotes in Corsica Island (France)

Autor: Falchi, Alessandra, Piras, Ignazio Stefano, Vona, Giuseppe, Calo, Carla Maria, Varesi, Laurent

Publikováno v: American Journal of Hematology
American Journal of Hematology, Wiley, 2008, 83 (2), pp.173. ⟨10.1002/ajh.21094⟩
American Journal of Hematology, 2008, 83 (2), pp.173. ⟨10.1002/ajh.21094⟩

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c0db18b6cf391af05fac5433e1185e5
https://hal.archives-ouvertes.fr/hal-00628446

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Spectrin self-association site: characterization and study of beta-spectrin mutations associated with hereditary elliptocytosis

Autor: C Craescu, S Pedroni, Marie-Christine Lecomte, H. Gautero, Didier Dhermy, Gaël Nicolas, Catherine Fournier

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 1998, 332 ( Pt 1), pp.81-9
ResearcherID

International audience; Most of hereditary elliptocytosis (HE) cases are related to a spectrin dimer (SpD) self-association defect. The severity of haemolysis is correlated with the extent of the SpD self-association defect, which itself depends on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8718ad80a78a192cc21a9a948bb8c741
https://europepmc.org/articles/PMC1219454/

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Molecular mechanism of the calcium-induced conformational change in the spectrin EF-hands

Autor: Pj Lacombe, Matti Saraste, Annalisa Pastore, Mark Pfuhl, Gilles Travé

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 1995, 14 (20), pp.4922-31
Europe PubMed Central

International audience; Calcium is a universally employed cytosolic messenger in eukaryotic cells. Most of the proteins that bind signalling calcium are members of the calmodulin superfamily and share two or more helix-loop-helix motifs known as EF-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed682f5e12d34e56b0b8adaf2b1eb93
https://hal.archives-ouvertes.fr/hal-03406445

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