Zobrazeno 1 - 10 of 16 pro vyhledávání: '"MESH: Somatic Hypermutation, Immunoglobulin"'
1
The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
Autor: Alexis Saintamand, Yves Denizot, Michel Cogné, Christelle Vincent-Fabert, Bernardo Reina-San-Martin, Pauline Rouaud, Isabelle Robert, Rémi Fiancette, Eric Pinaud, Marie Marquet
Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2013, 210 (8), pp.1501-7. ⟨10.1084/jem.20130072⟩
Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
Interactions with cognate antigens r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80c73517706ccf8515835fcf135780f
https://doi.org/10.1084/jem.20130072
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2
Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate
Autor: Benoit Arcangioli, Hanen Ouadani, Beya Larguèche, Imen Ben-Mustapha, Hatem Masmoudi, François Rougeon, Houda Elloumi-Zghal, Mohamed-Ridha Barbouche, Tihana Jovanic, Meriem Ben-Ali, Mongia Hachicha, Dahmani M. Fathallah, Sylvie Garcia
Publikováno v: Molecular Immunology
Molecular Immunology, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
Molecular Immunology, Elsevier, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
International audience; Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper Ig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d198ff026ab2745225baea1a94295f
https://hal-riip.archives-ouvertes.fr/pasteur-01453058
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3
MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation
Autor: Tanja A. Schwickert, Kevin M. McBride, Mila Jankovic, Michel C. Nussenzweig, Thomas Eisenreich, Gordon F. Heidkamp, To-Ha Thai, Davide F. Robbiani, Michela Di Virgilio, Yair Dorsett, Bernardo Reina San-Martin, Anna Gazumyan, Klaus Rajewsky
Publikováno v: Immunity
Immunity, Elsevier, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
Immunity, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
International audience; MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA-mRNA interaction in vivo, we generated mice that car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9484aee3b6ffa7c023b50153d0ca3b4
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4
DNA polymerases in adaptive immunity. : DNA polymerases in adaptive immunity
Autor: Claude-Agnès Reynaud, Jean-Claude Weill
Publikováno v: Nature Reviews Immunology
Nature Reviews Immunology, Nature Publishing Group, 2008, 8 (4), pp.302-12. 〈10.1038/nri2281〉
review article; International audience; To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cc4aed7a5c2ed9f5d3f7950899c4c5
https://doi.org/10.1038/nri2281
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5
DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
Autor: Said Aoufouchi, Frédéric Delbos, Jean-Claude Weill, Claude-Agnès Reynaud, Ahmad Faili
Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2007, 204 (1), pp.17-23. ⟨10.1084/jem.20062131⟩
Journal of Experimental Medicine, 2007, 204 (1), pp.17-23. ⟨10.1084/jem.20062131⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2007, 204 (1), pp.17-23. 〈10.1084/jem.20062131〉
The Journal of Experimental Medicine
International audience; Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bc73de6ce77970f0485f5196b8dc71
https://doi.org/10.1084/jem.20062131
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6
DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
Autor: Sandra Weller, Anne Stary, Claude-Agnès Reynaud, Alain Sarasin, Jean-Claude Weill, Said Aoufouchi, Ahmad Faili, Françoise Vuillier
Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
Journal of Experimental Medicine, Rockefeller University Press, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2004, 199 (2), pp.265-70. 〈10.1084/jem.20031831〉
The Journal of Experimental Medicine
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43782f0cda1bfdfaf99eb0f99969e78c
https://doi.org/10.1084/jem.20031831
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7
Human blood IgM 'memory' B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
Autor: C.A. Reynaud, Mary Ellen Conley, Louis M. Staudt, Olivier Tournilhac, J.C. Weill, Jean-Laurent Casanova, Damien Bonnet, Andreas Rosenwald, Sandra K. Weller, Corinne Cordier, Bruce K. Tan, Gil Tchernia, Birte Steiniger, Alessandro Plebani, Moritz C. Braun, D S Kumararatne
Publikováno v: Blood
Blood, American Society of Hematology, 2004, 104 (12), pp.3647-54. ⟨10.1182/blood-2004-01-0346⟩
Blood, American Society of Hematology, 2004, 104 (12), pp.3647-54. 〈10.1182/blood-2004-01-0346〉
Blood, 2004, 104 (12), pp.3647-54. ⟨10.1182/blood-2004-01-0346⟩
International audience; The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f4a10e0b5bb198d51c89a63d3329ea
https://www.hal.inserm.fr/inserm-00338311/document
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9
Selection of individual VH genes occurs at the pro-B to pre-B cell transition
Autor: Philip L. Cohen, Emily Xue, Avinash Maganty, Martin Weigert, Eline T. Luning Prak, Lenka Yunk, Wenzhao Meng, Li-San Wang, Stéphane Mancini, Robert A. Eisenberg
Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (4), pp.1835-44. ⟨10.4049/jimmunol.1100207⟩
Journal of Immunology, 2011, 187 (4), pp.1835-44. ⟨10.4049/jimmunol.1100207⟩
B cells are subjected to selection at multiple checkpoints during their development. The selection of Ab H chains is difficult to study because of the large diversity of the CDR3. To study the selection of individual Ab H chain V region genes (VH), w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9be09d6c32939c1abd92faf2093a0e
https://pubmed.ncbi.nlm.nih.gov/21746964
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10
DNA polymerases in adaptive immunity.: DNA polymerases in adaptive immunity
Autor: Weill, Jean-Claude, Reynaud, Claude-Agnès
Publikováno v: Nature Reviews Immunology
Nature Reviews Immunology, 2008, 8 (4), pp.302-12. ⟨10.1038/nri2281⟩
Nature Reviews Immunology, Nature Publishing Group, 2008, 8 (4), pp.302-12. ⟨10.1038/nri2281⟩
review article; International audience; To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::33bd1464ab00cd9d0b7fe755cb850feb
https://www.hal.inserm.fr/inserm-00281241/document
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