Elaboration of a clinical and paraclinical score to estimate the probability of herpes simplex virus encephalitis in patients with febrile, acute neurologic impairment

Autor: D. Keil, Arnaud Seigneurin, Raphaële Germi, A. Rallo, Stéphane Gennai, Olivier Epaulard

Publikováno v: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, 2016, 35 (6), pp.935-939. ⟨10.1007/s10096-016-2619-7⟩
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2016, 35 (6), pp.935-939. ⟨10.1007/s10096-016-2619-7⟩

International audience; Herpes simplex virus (HSV) encephalitis is associated with a high risk of mortality and sequelae, and early diagnosis and treatment in the emergency department are necessary. However, most patients present with non-specific fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4da5660e636d7666a4987f19bfa4719
https://hal.science/hal-02060068

Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia

Autor: Pierre Fillatre, H. Leroy, Y. Le Tulzo, Stéphane Jouneau, Pierre Tattevin, Matthieu Revest, Florence Robert-Gangneux, Sylviane Chevrier, Sophie Minjolle, Arnaud Gacouin

Publikováno v: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2013, 32 (2), pp.189-94. ⟨10.1007/s10096-012-1730-7⟩
European Journal of Clinical Microbiology & Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, 2013, 32 (2), pp.189-94. ⟨10.1007/s10096-012-1730-7⟩

International audience; The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605f7f4f82fc9fb94e31dc3f31646b2b
https://www.hal.inserm.fr/inserm-00872789

Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance

Autor: Sebastian Gorke, Marina Deschamps, Boris Fehse, Emad Bennour, Waseem Qasim, Pierre Tiberghien, Jean-Marie Certoux, Christophe Ferrand, Eric Robinet, Anne Duperrier, Jean-Paul Remy-Martin, H. Bobby Gaspar, Thomas F. Baumert

Publikováno v: Human Gene Therapy
Human Gene Therapy, Mary Ann Liebert, 2008, 19 (7), pp.699-709. ⟨10.1089/hum.2007.060⟩
Human Gene Therapy, 2008, 19 (7), pp.699-709. ⟨10.1089/hum.2007.060⟩

International audience; Donor T cell alloreactivity can be efficiently controlled by retrovirus-mediated ex vivo transfer of a "suicide" gene encoding the wild-type herpes simplex virus thymidine kinase (wtHSV-tk) gene, allowing gene-modified cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c164bbc9b53eceb0b7213f60081a54
https://www.hal.inserm.fr/inserm-00483378

Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft

Autor: Christophe Ferrand, Pierre Tiberghien, Céline Pagneux, Eric Robinet, Patricia Mercier-Lethondal, Jean-Yves Cahn, Carole Henry, Bruno Lioure, Eric Deconinck, Jean Marie Certoux, Marina Deschamps

Publikováno v: Blood
Blood, American Society of Hematology, 2007, 110 (12), pp.3842-52. ⟨10.1182/blood-2007-04-087346⟩

In our previous phase 1/2 study aimed at controlling graft-versus-host disease, 12 patients received Herpes simplex virus thymidine kinase (HSV-tk+)/neomycin phosphotransferase (NeoR+)–expressing donor gene-modified T cells (GMCs) and underwent an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84690c0d3a114e8939b3ebb70c9c6dda
https://www.hal.inserm.fr/inserm-00479711

Virus-free transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment induces tumor cell death

Autor: Calvez, V., Rixe, O., Wang, P., Mouawad, R., Soubrane, C., Ghoumari, A., Verola, O., Khayat, D., Colbère-Garapin, F.

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, 1996, 2 (1), pp.47-51
Clinical Cancer Research, American Association for Cancer Research, 1996, 2 (1), pp.47-51

We report virus-free transfer of a "suicide" gene into tumoral cells. The system can be used in vitro or in vivo to induce tumor cell death. A plasmid carrying the herpes simplex virus thymidine kinase (HSV-TK) gene with its 5'- and 3'-flanking regio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2faa97e6aff391fd3849dc5045e28d27
https://hal-pasteur.archives-ouvertes.fr/pasteur-00167275