Výsledky vyhledávání - "MESH: Signal Transduction/immunology"

Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

Publikováno v: Immunity, 53 (4
Immunity
Immunity, Elsevier, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩
Immunity, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩

Through complementary approaches, involving cancer patients’ samples and relevant mouse tumor models, Weulersse et al. reveal that CD8 T cells in the tumor microenvironment lose expression of the activating receptor CD226 (DNAM-1) in a manner that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfe5be6f45852b02f2ba60ac27610fa
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/316003

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Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis

Autor: Mindy Tsai, Nicolas Gaudenzio, Axel Roers, See-Ying Tam, Yuko Kawakami, Pierre Chambon, Philipp Starkl, Dimitri Pirottin, Stephen J. Galli, Sophie El Abbas, Jinah Kim, Nadine Antoine, Fabrice Bureau, Oliwia W Zurek, Laurent L. Reber, Toshiaki Kawakami, Thomas Marichal, Riccardo Sibilano

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2016, 126 (12), pp.4497-4515. ⟨10.1172/JCI86359⟩

International audience; Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542066fd135b8c7de9d713b77f413dc3
https://doi.org/10.1172/jci86359

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Cutting Edge: A Dual Role for Type I IFNs during Polyinosinic-Polycytidylic Acid-Induced NK Cell Activation

Autor: Isabelle Bouvier, James P. Di Santo, Matthew L. Albert, Jacques Deguine, Hélène Beuneu, Philippe Bousso

Publikováno v: Journal of Immunology
Journal of Immunology, 2011, 187 (5), pp.2084-8. ⟨10.4049/jimmunol.1004210⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (5), pp.2084-8. ⟨10.4049/jimmunol.1004210⟩

NK cells are cytotoxic lymphocytes that are most efficient at fulfilling their functions after a phase of priming provided by cytokines and/or accessory cells. Although type I IFNs are known to be important in this process, it remains unclear whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f6bb8c37df30c2e732e6299e8ec549
https://doi.org/10.4049/jimmunol.1004210

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Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes

Publikováno v: Gastroenterology
Gastroenterology, 2018, 154 (8), pp.2237-2251.e16. ⟨10.1053/j.gastro.2018.03.020⟩
Gastroenterology, WB Saunders, 2018, 154 (8), pp.2237-2251.e16. ⟨10.1053/j.gastro.2018.03.020⟩

International audience; Background & Aims: Hepatitis C virus (HCV) infections most often result in chronic outcomes, although the virus constantly produces replication intermediates, in particular double-stranded RNA (dsRNA), representing potent indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdb70da0420c330868ac469be32c258
https://doi.org/10.1053/j.gastro.2018.03.020

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Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

Autor: Hui Xiao, Numan Javed, Guang Xue, Guangxun Meng, Yue Xing, Gerald F. Späth, Ailing Lu, Yoichiro Iwakura, Hervé Lecoeur

Publikováno v: Cytokine
Cytokine, Elsevier, 2016, 81, pp.101-108. ⟨10.1016/j.cyto.2016.03.007⟩
Cytokine, 2016, 81, pp.101-108. ⟨10.1016/j.cyto.2016.03.007⟩

International audience; Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87936c8a3631d257b3429a962b4524ef
https://pubmed.ncbi.nlm.nih.gov/26978550

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Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis

Autor: Laurent Boyer, Emmanuel Lemichez

Publikováno v: Small GTPases
Small GTPases, Taylor & Francis, 2015, 6 (4), pp.186-188. ⟨10.1080/21541248.2015.1095698⟩

International audience; The monitoring of the activation state of Rho GTPases has emerged as a potent innate immune mechanism for detecting pathogens. In the March issue of PLOS Pathogens, we show that the activation of Rho GTPases by the CNF1 toxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17226ee95ed7313fefd5e1788a5eccb
https://hal-pasteur.archives-ouvertes.fr/pasteur-02448674

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Shigella impairs T lymphocyte dynamics in vivo

Autor: Armelle Phalipon, Philippe J. Sansonetti, Ellen T. Arena, Philippe Bousso, Katharina Nothelfer, Gernot Sellge, Wilmara Salgado-Pabón, Elisabetta Frigimelica, Susanna Celli, Pascal Roux

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (12), pp.4458-4463. ⟨10.1073/pnas.1300981110⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (12), pp.4458-4463. ⟨10.1073/pnas.1300981110⟩

The Gram-negative enteroinvasive bacterium Shigella flexneri is responsible for the endemic form of bacillary dysentery, an acute rectocolitis in humans. S. flexneri uses a type III secretion system to inject effector proteins into host cells, thus d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f850b87a987a43c994c8f303d090ffd

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TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Autor: Christian Reinhard, Federico Santoni, Stéphane Hausmann, Matthew J Albert, Jessica Guerra, Aurélie Bisiaux, Caterina Strambio-De-Castillia, Thomas Pertel, Massimo Pizzato, Walther Mothes, Pradeep D. Uchil, Jeremy Luban, Josefina Lascano, Markus G. Grütter, Sara Züger, Laurence Chatel, Damien Morger

Publikováno v: Nature
Nature, Nature Publishing Group, 2011, 472 (7343), pp.361-5. ⟨10.1038/nature09976⟩
Nature, 2011, 472 (7343), pp.361-5. ⟨10.1038/nature09976⟩
Nature, Vol. 472, No 7343 (2011) pp. 361-365
Nature, vol. 472, no. 7343, pp. 361-5

International audience; TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus invasion of the target cell cytoplasm. Antiviral potency correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f87a4daed9097a6a6339041a9f7eb9
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402086

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The role of ERK5 in T-cell signalling

Autor: Martin Villalba, Seyma Cherni, Robert A. Hipskind, Sandra Kaminski, Johan Garaude

Publikováno v: Scandinavian Journal of Immunology
Scandinavian Journal of Immunology, Wiley, 2005, 62 (6), pp.515--20. ⟨10.1111/j.1365-3083.2005.01696.x⟩

International audience; The mitogen-activated protein kinase (MAPK) ERK5 plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development. In nonhaematopoietic cells, mitogenic and stress signals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6947d2aa8323ea5029f8eb244580ef41
https://hal.archives-ouvertes.fr/hal-02262228

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