Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Autor: Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508e22176087bbcbdf320820985074e
http://link.springer.com/article/10.1038/s41467-018-07339-y