Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival

Autor: Matthieu Ribon, Lorenzo Schiaffino, Christian S Lobsiger, Michel Mallat, Pierre de la Grange, Félix Berriat, Danielle Seilhean, Delphine Bohl, Charlène Iltis, Séverine Boillée, Aude Chiot, Sakina Zaïdi, Ariane Jolly, Stéphanie Millecamps

Publikováno v: Nature Neuroscience
Nature Neuroscience, 2020, 23 (11), pp.1339-1351. ⟨10.1038/s41593-020-00718-z⟩

International audience; Microglia and peripheral macrophages have both been implicated in amyotrophic lateral sclerosis (ALS), although their respective roles have yet to be determined. We now show that macrophages along peripheral motor neuron axons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03c7fd8040600fa883a8e6cef24583d
https://doi.org/10.1038/s41593-020-00718-z

A transgenic mouse expressing CHMP2Bintron5mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia

Autor: Frédérique René, Aurelia Vernay, Thiebault Lequeu, Robin Waegaert, Béatrice Blot, François Sellal, Jean-Philippe Loeffler, Rémy Sadoul, Valerie Risson, Sylvie Dirrig-Grosch, Ludivine Therreau, Laurent Schaeffer

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2016, 25 (15), pp.3341-3360. ⟨10.1093/hmg/ddw182⟩
Human Molecular Genetics, Oxford University Press (OUP), 2016, 25 (15), pp.3341-3360. ⟨10.1093/hmg/ddw182⟩

International audience; Mutations in the charged multivesicular body protein 2B (CHMP2B) are associated with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and with a mixed ALS-FTD syndrome. To model this syndrome, we generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3b5d36195b81030584c56d35a074bb
https://doi.org/10.1093/hmg/ddw182

Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings

Autor: Franck Marin, Bertrand Bruneau, Philippe Violas, Laurent Riffaud, Yves Gandon, Anne Michel, Jean-Yves Gauvrit, Adrien Roux, Catherine Tréguier

Publikováno v: Pediatric Radiology
Pediatric Radiology, Springer Verlag, 2012, 42 (8), pp.952-8. ⟨10.1007/s00247-012-2418-y⟩
Pediatric Radiology, 2012, 42 (8), pp.952-8. ⟨10.1007/s00247-012-2418-y⟩

International audience; BACKGROUND: Localized hypertrophic neuropathy (LHN) of the sciatic nerve in children is a rare condition characterized by a painless neurological deficit in the sciatic nerve territory. OBJECTIVE: To demonstrate the role of MR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f3af72b61ebc8c28f886b2c0b50d64
https://doi.org/10.1007/s00247-012-2418-y

Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination

Autor: Lee A. Witters, Jérôme Salles, Françoise Sargueil, Bertrand Garbay, Claude Cassagne, Anja Knoll-Gellida

Publikováno v: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2003, 1631 (3), pp.229-238. ⟨10.1016/s1388-1981(03)00041-6⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2003, 1631 (3), pp.229-238. ⟨10.1016/s1388-1981(03)00041-6⟩

International audience; The expression of acetyl-CoA carboxylase (ACC) in mouse peripheral nervous system (PNS) was investigated. Both ACC 265 and ACC 280 isoforms were expressed in the sciatic nerve, although ACC 265 was predominant. ACC 265 transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c1a3ff73e6fa45da75bc6b425453e0
https://doi.org/10.1016/s1388-1981(03)00041-6

M2 muscarinic receptor activation regulates schwann cell differentiation and myelin organization

Autor: Uggenti, Carolina, De Stefano, M Egle, Costantino, Michele, Loreti, Simona, Pisano, Annalinda, Avallone, Bice, Talora, Claudio, Magnaghi, Valerio, Tata, Ada Maria

Publikováno v: Developmental Neurobiology
Developmental Neurobiology, Wiley, 2014, 74 (7), pp.676-91. ⟨10.1002/dneu.22161⟩

International audience; Glial cells express acetylcholine receptors. In particular, rat Schwann cells express different muscarinic receptor subtypes, the most abundant of which is the M2 subtype. M2 receptor activation causes a reversible arrest of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f9a865e4b3fec537788fd72c666e88be
http://hdl.handle.net/11588/572067