Výsledky vyhledávání - "MESH: STAT5 Transcription Factor"

A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling

Autor: Sylviane Hoos, Chi Zhang, Gitte W. Haxholm, Patrick England, Birthe B. Kragelund, Isabelle Broutin, Florence Boutillon, Mads Nygaard, Marie Bernadet, Vincent Goffin

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩
Journal of Biological Chemistry, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩

Cytokine receptors elicit several signaling pathways, but it is poorly understood how they select and discriminate between them. We have scrutinized the prolactin receptor as an archetype model of homodimeric cytokine receptors to address the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8d333304e6a7dd4f047e2215330516
https://doi.org/10.1074/jbc.m115.639096

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Allium Roseum L. Extract Exerts Potent Suppressive Activities on Chronic Myeloid Leukemia K562 Cell Viability Through the Inhibition of BCR-ABL, PI3K/Akt, and ERK1/2 Pathways and the Abrogation of VEGF Secretion

Autor: Soumaya Souid, H. Karoui, Ingrid Arnault, Makram Essafi, Mohamed Neffati, Ichrak Riahi-Chebbi, Meriam Haoues, Hanen Najjaa, Khadija Essafi-Benkhadir, Jacques Auger

Publikováno v: Nutrition and Cancer
Nutrition and Cancer, Taylor & Francis (Routledge), 2017, 69 (1), pp.117-130. ⟨10.1080/01635581.2017.1248295⟩

International audience; Use of plant extracts, alone or combined to the current chemotherapy as chemosensitizers, has emerged as a promising strategy to overcome tumor drug resistance. Here, we investigated the anticancer activity of Allium roseum L.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8301f04dad4d2ceb5ca0407f07fb6fbe
https://hal-riip.archives-ouvertes.fr/pasteur-01432747

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IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death

Autor: Theresa L. Whiteside, Marta Szajnik, H Brandwein, Miroslaw J. Szczepanski, J W Hadden, J Han, K Signorelli, K Quadrini, Malgorzata Czystowska

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. 〈10.1038/cdd.2008.197〉

International audience; IRX-2 is a cytokine-based biologic agent that has the potential to enhance antitumor immune responses. We investigated whether IRX-2 can protect T cells from tumor-induced apoptosis. Tumor-derived microvesicles (MV) expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4405aefc4179838cd033255d4555d7ba
https://doi.org/10.1038/cdd.2008.197

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LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.: LEPROTs decrease growth hormone signaling

Autor: Céline Cudejko, Eric Bauge, Jean-Pierre Salles, Réjane Paumelle, Thierry Touvier, Bernard Bailleul, Olivier Briand, Bart Staels, Sandrine Caron, Francoise Conte-Auriol, Yves Rouillé

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2009, 119 (12), pp.3830-8. ⟨10.1172/JCI34997⟩

International audience; Growth hormone (GH) is a major metabolic regulator that functions by stimulating lipolysis, preventing protein catabolism, and decreasing insulin-dependent glucose disposal. Modulation of hepatic sensitivity to GH and the down

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4507b5664899b1e65d3ac3d7f43d44d5
https://doi.org/10.1172/jci34997

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In vitro and in vivo effects of zinc on cytokine signalling in human T cells

Autor: George Dedoussis, Fiorella Marcellini, Stavroula Kanoni, Marco Malavolta, Tamas Fulop, Anis Larbi, Georges Herbein, Daniela Monti, Audrey Varin, Eugenio Mocchegiani, Jolanta Jajte, Lothar Rink

Publikováno v: Experimental Gerontology
Experimental Gerontology, Elsevier, 2008, 43 (5), pp.472-82. ⟨10.1016/j.exger.2007.12.008⟩

International audience; Aging is associated with changes in the immune response which are collectively called immunosenescence. The changes mainly affect the adaptive immune response and especially the T cell-mediated cellular immune response. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbdd703a1849c0e447fd3f98ffa9010
https://doi.org/10.1016/j.exger.2007.12.008

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Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B

Autor: Jacques A. Nunès, Magali Grange, Romain Roncagalli, Guylène Firaguay, Nathalie Auphan-Anezin, Anne-Marie Schmitt-Verhulst, Jacques Ghysdael, Amandine Mas, Marilyn Giordano

Publikováno v: Immunology
Immunology, Wiley, 2015, 145 (4), pp.543-57. ⟨10.1111/imm.12471⟩
Immunology, 2015, 145 (4), pp.543-57. ⟨10.1111/imm.12471⟩

International audience; CD8 T cells used in adoptive immunotherapy may be manipulated to optimize their effector functions, tissue-migratory properties and long-term replicative potential. We reported that antigen-stimulated CD8 T cells transduced to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1fcdb14c641d75e1620cc3b0246963
https://www.hal.inserm.fr/inserm-01420012

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STAT5-Mediated Signals Sustain a TCR-Initiated Gene Expression Program toward Differentiation of CD8 T Cell Effectors

Autor: Denis Puthier, Grégory Verdeil, Anne-Marie Schmitt-Verhulst, Nathalie Auphan-Anezin, Catherine Nguyen

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (8), pp.4834-42
Journal of Immunology, 2006, 176 (8), pp.4834-42
Scopus-Elsevier

Poorly functional effector CD8 T cells are generated in some pathological situations, including responses to weakly antigenic tumors. To identify the molecular bases for such defective differentiation, we monitored gene expression in naive monoclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3950048a694dd22c3108f8599dd5676
https://doi.org/10.4049/jimmunol.176.8.4834

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Membrane Microdomains and Cytoskeleton Organization Shape and Regulate the IL7-Receptor Signalosome in Human CD4 T-Cells

Autor: Jacques Thèze, Florence Bugault, Ulf Schwarz, Vincent Lavergne, Thierry Rose, Anne-Hélène Pillet, Blanche Tamarit, Pascal Bochet, Nathalie Garin

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (12), pp.8691-8701. ⟨10.1074/jbc.M113.449918⟩
Journal of Biological Chemistry, 2013, 288 (12), pp.8691-8701. ⟨10.1074/jbc.M113.449918⟩

International audience; Interleukin(IL)-7 is the main homeostatic regulator of CD4 T-lymphocytes (helper) at both central and peripheral levels. Upon activation by IL-7, several signalling pathways, mainly Jak/STAT, PI3K/Akt and MAPK, induce the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae84103c33230a84c84999f2b220684e
https://hal-pasteur.archives-ouvertes.fr/pasteur-02397495

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Autor: Jean-Claude Capiod, Isabelle Dusanter-Fourt, François Dreyfus, Jacques Delobel, Fabrice Gouilleux, Renate Weber-Nordt, Jean-François Claisse, Bernd Groner, Valérie Gouilleux-Gruart, Lionel Prin, Corinne Desaint

Publikováno v: Blood
Blood, American Society of Hematology, 1996, 87 (5), pp.1692-1697. ⟨10.1182/blood.V87.5.1692.1692⟩

A signal transduction pathway activated by many cytokines has recently been elaborated. The JAK kinases and the signal transducers and activators of transcription (STAT) factors have been found to be essential components. In this report, we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071cddd81a735a4d89fd9b2e4ccaf5fa
https://doi.org/10.1182/blood.v87.5.1692.1692

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Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature

Autor: Mylène Tajan, Marianne Mus, Thomas Edouard, Karine Tréguer, Jean-Pierre Salles, Alexandra Montagner, Armelle Yart, Patrick Raynal, Toshiyuki Araki, M. Tauber, Philippe Valet, Audrey De Rocca Serra-Nédélec, Marie Dance, Benjamin G. Neel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 11 (109), 4257-4262. (2012)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-62. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩

Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 ( PTPN11 ), is characterized by congenital cardiopathies, facial dysmorphic features, and short stature. How mutated SHP2 induces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b331c42273a01c5f8af7d797ede56951
http://prodinra.inra.fr/record/387290

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