Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

Autor: Martine Guillermier, Carole Escartin, Océane Guillemaud, Alexis-Pierre Bemelmans, Charlène Joséphine, Gilles Bonvento, Emmanuel Brouillet, Kelly Ceyzériat, Thomas Saint-Georges, Philippe Hantraye, Maria-Angeles Carrillo-de Sauvage, Karine Cambon, Sueva Bernier, Fanny Petit, Lucile Ben Haim, Anne-Sophie Hérard

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩
Neurobiology of Aging, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩

In Alzheimer disease (AD), astrocytes undergo complex changes and become reactive. The consequences of this reaction are still unclear. To evaluate the net impact of reactive astrocytes in AD, we recently developed viral vectors targeting astrocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b28753aa9921b953676af06fa844c9
https://doi.org/10.1016/j.neurobiolaging.2020.02.010

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Autor: Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina

Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩

Comment in :Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song. [Sci Immunol. 2018]; International audience; Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

Autor: Umeshree Govender, Frédérique Michel, Yasmine Bourdache, Sandra Pellegrini, Béatrice Corre

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩
Journal of Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩

Type I IFN can exert pro- and anti-inflammatory activities in the immune system. Here, we have investigated the mechanism by which IFN-α enhances early expression of the anti-inflammatory cytokine IL-10 in human CD45RA+CD4+ T cells. With the use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2464e50cc98856b4358c2ff846e243
https://hal-pasteur.archives-ouvertes.fr/pasteur-02136992

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Autor: Tomi P. Mäkelä, Kari Vaahtomeri, Yajing Gao, Sushil Tripathi, Iris P. L. Wong, Benoit Viollet, Eva Domenech-Moreno, Yan Yan, Nalle Pentinmikko, Timothy C. Wang, Gustavo Leone, Elina H. Niemelä, Saara Ollila, Kaisa Laajanen, Pekka Katajisto

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩

International audience; Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6274585620cb1bbf0318b556f33ec3f5
https://pubmed.ncbi.nlm.nih.gov/29202476

CD5 Promotes IL-10 Production in Chronic Lymphocytic Leukemia B Cells through STAT3 and NFAT2 Activation

Autor: Sébastien Lemoine, Soizic Garaud, Sophie Hillion, Christian Berthou, Anne Bordron, Jacques-Olivier Pers, Ahsen Morva, Yves Renaudineau, Rizgar A. Mageed, Pierre Youinou

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 186 (8), pp.4835-44. ⟨10.4049/jimmunol.1003050⟩

B lymphocytes from chronic lymphocytic leukemia (CLL) display some CD5 transcripts for CD5 containing the known exon 1 (E1A) and other CD5 transcripts containing the new exon 1 (E1B). These malignant B cells, as well as B cell lines transfected with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760c41f872dbc3917c24b803d5281584
https://doi.org/10.4049/jimmunol.1003050