Retinoid receptor subtype-selective modulators through synthetic modifications of RARγ agonists

Autor: Hinrich Gronemeyer, Pierre Germain, Harshal Khanwalkar, Géraldine Lemaire, Rosana Alvarez, Fátima Rodríguez-Barrios, Angel R. de Lera, Susana Alvarez

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2009, 17 (13), pp.4345-59. ⟨10.1016/j.bmc.2009.05.035⟩

International audience; A series of retinoids designed to interfere with the repositioning of H12 have been synthesized to identify novel RARgamma antagonists based on the structure of known RARgamma agonists. The transcriptional activities of the no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c02dfefc0300f16ec94876f40185f08
https://doi.org/10.1016/j.bmc.2009.05.035

Retinoic acid via RARα inhibits the expression of 24-hydroxylase in human prostate stromal cells

Autor: Susanna Miettinen, Hiroyuki Kagechika, Pentti Tuohimaa, Hinrich Gronemeyer, Yan-Ru Lou

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2005, 338 (4), pp.1973-81. ⟨10.1016/j.bbrc.2005.10.178⟩

International audience; 25-Hydroxyvitamin D(3)-24-hydroxylase (24-hydroxylase) is an important inactivating enzyme and its expression is induced by 25-hydroxyvitamin D3 (25OHD3) and 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3) through action of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc2b3990edf8889b1394310ef5e674b
https://doi.org/10.1016/j.bbrc.2005.10.178

Retinoid hyposignaling contributes to aging-related decline in hippocampal function in short-term/working memory organization and long-term declarative memory encoding in mice

Autor: Frédérique Mingaud, Véronique Pallet, Betty Niedergang, Robert Jaffard, Wojciech Krezel, Paul Higueret, Nicole Etchamendy, Aline Marighetto, Marta Wietrzych, Nicole Mons, Cécile Mormède

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2008, 28 (1), pp.279-91. ⟨10.1523/JNEUROSCI.4065-07.2008⟩
Journal of Neuroscience, 2008, 28 (1), pp.279-91. ⟨10.1523/JNEUROSCI.4065-07.2008⟩
Journal of Neuroscience, Society for Neuroscience, 2008, 28 (1), pp.279-291. ⟨10.1523/JNEUROSCI.4065-07.2008⟩

An increasing body of evidence indicates that the vitamin A metabolite retinoic acid (RA) plays a role in adult brain plasticity by activating gene transcription through nuclear receptors. Our previous studies in mice have shown that a moderate downr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3aac58a86b7e5c7f93fd2f5c85ffbc
https://hal.archives-ouvertes.fr/hal-00283110

Design of selective nuclear receptor modulators: RAR and RXR as a case study

Autor: William Bourguet, Lucia Altucci, Angel R. de Lera, Hinrich Gronemeyer

Publikováno v: Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, Nature Publishing Group, 2007, 6 (10), pp.811-20. ⟨10.1038/nrd2398⟩

Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be modulated therapeutically by small-molecule ligands. Although compounds that target these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f2e80fbf9bfa8c9264cfda8590f88d
https://hal.archives-ouvertes.fr/hal-00188872

International Union of Pharmacology. LXIII. Retinoid X receptors

Autor: Ronald M. Evans, Hinrich Gronemeyer, Angel R. de Lera, Mark Leid, Mitchell A. Lazar, Pierre Chambon, Pierre Germain, Reuben Lotan, David J. Mangelsdorf, Gregor Eichele

Publikováno v: Pharmacological Reviews
Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics, 2006, 58 (4), pp.760-72. ⟨10.1124/pr.58.4.7⟩

International audience; The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b474bf4375af51c39a91f4bfc33d4eda
https://hal.archives-ouvertes.fr/hal-00187925