Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver

Autor: Anne Tailleux, Barbara Gross, Fanny Lalloyer, Emmanuelle Vallez, Sophie Lestavel, Thomas Åskov Pedersen, Bart Staels, Saïd Yous, Catherine Fievet, Jan-Ake Gustafsson, Susanne Mandrup

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2009, 29 (10), pp.1488-95. ⟨10.1161/ATVBAHA.109.189506⟩
Lalloyer, F, Pedersen, T Å, Gross, B, Lestavel, S, Yous, S, Vallez, E, Gustafsson, J-Å, Mandrup, S, Fiévet, C, Staels, B & Tailleux, A 2009, ' Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 10, pp. 1488-1495 . https://doi.org/10.1161/ATVBAHA.109.189506

Objective— Bexarotene (Targretin) is a clinically used antitumoral agent which exerts its action through binding to and activation of the retinoid-X-receptor (RXR). The most frequent side-effect of bexarotene administration is an increase in plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2e41fa53f67f77e28bf39bfb300cb5
https://doi.org/10.1161/atvbaha.109.189506

RAR and RXR modulation in cancer and metabolic disease

Autor: Hinrich Gronemeyer, Lucia Altucci, Kathleen M. Ogilvie, Angel R. de Lera, Mark D. Leibowitz

Publikováno v: dressNature Reviews Drug Discovery
dressNature Reviews Drug Discovery, 2007, 6 (10), pp.793-810. ⟨10.1038/nrd2397⟩

Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The success of RAR modulation in the treatment of acute promyelocytic leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8d85c9025057ceeaf89aa718817d5a
https://doi.org/10.1038/nrd2397

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin

Autor: Marius Teletin, Pierre Chambon, Mei Li, Jean-Louis Pasquali, Nadia Messaddeq, Daniel Metzger

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2005, 102 (41), pp.14795-800. ⟨10.1073/pnas.0507385102⟩

To investigate the role of retinoid X receptors (RXRs) in epidermal homeostasis, we generated RXRαβ ep-/- somatic mutants in which both RXRα and RXRβ are selectively ablated in epidermal keratinocytes of adult mice. These mice develop a chronic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d76994cced08e9ab33826464862d45
https://doi.org/10.1073/pnas.0507385102

Retinoid X receptors: common heterodimerization partners with distinct functions

Autor: Bart Staels, Yacir Benomar, Philippe Lefebvre

Publikováno v: Trends Endocrinol Metab
Trends Endocrinol Metab, 2010, 21 (11), pp.676-83. ⟨10.1016/j.tem.2010.06.009⟩

International audience; Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only from the ability of RXRs to dimerize with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd16c6917b45f81fffff96c9ee79ba02
https://www.hal.inserm.fr/inserm-00521590

Design of selective nuclear receptor modulators: RAR and RXR as a case study

Autor: William Bourguet, Lucia Altucci, Angel R. de Lera, Hinrich Gronemeyer

Publikováno v: Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, Nature Publishing Group, 2007, 6 (10), pp.811-20. ⟨10.1038/nrd2398⟩

Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be modulated therapeutically by small-molecule ligands. Although compounds that target these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f2e80fbf9bfa8c9264cfda8590f88d
https://hal.archives-ouvertes.fr/hal-00188872