Výsledky vyhledávání - "MESH: Recombinant Proteins / metabolism"

Development of screening methods for functional characterization of UGTs from Stevia rebaudiana

Autor: Veronica Vallejo, Laurent Camborde, Monique Berger, Jean Daydé, Eva Petit, Alban Jacques

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.15137. ⟨10.1038/s41598-020-71746-9⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

Glycosylation is a key modification that contributes to determine bioactivity and bioavailability of plant natural products, including that of terpenoids and steviol glycosides (SVglys). It is mediated by uridine-diphosphate glycosyltransferases (UGT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886e9ca646dc72fd0c8c449f8fb16caa
https://pubmed.ncbi.nlm.nih.gov/32934264

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The pore structure of Clostridium perfringens epsilon toxin

Autor: Savva, Christos, Clark, Alice, Naylor, Claire, Popoff, Michel, Moss, David, Basak, Ajit, Titball, Richard, Bokori-Brown, Monika

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2641. ⟨10.1038/s41467-019-10645-8⟩
Nature Communications, 2019, 10 (1), pp.2641. ⟨10.1038/s41467-019-10645-8⟩

Epsilon toxin (Etx), a potent pore forming toxin (PFT) produced by Clostridium perfringens, is responsible for the pathogenesis of enterotoxaemia of ruminants and has been suggested to play a role in multiple sclerosis in humans. Etx is a member of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::03b5647c6160a8077e0ad0ee01cd113c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02454060

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Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis

Autor: Paul R. Thompson, Hidenari Takahara, Laura Cau, Guy Serre, Michel Simon, Marie-Claire Méchin

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
J Invest Dermatol

International audience; Deimination, a post-translational modification catalyzed by a family of enzymes called peptidylarginine deiminases (PADs), is the conversion of arginine into citrulline residues in a protein. Deimination has been associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f9749a5b19b13328a286eb478c2584
https://ut3-toulouseinp.hal.science/hal-03156447/document

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Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Autor: Christine Petit, Florent Delhommel, Benjamin Bardiaux, Julia Chamot-Rooke, Michael Nilges, Sébastien Brier, Florence Cordier, Amel Bahloul, Bertrand Raynal, Sylvie Nouaille, Nicolas Wolff, Baptiste Colcombet-Cazenave, Guillaume Bouvier

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2017, 25 (11), pp.1645-1656.e5. ⟨10.1016/j.str.2017.08.013⟩
Structure, 2017, 25 (11), pp.1645-1656.e5. ⟨10.1016/j.str.2017.08.013⟩

International audience; Hearing relies on the transduction of sound-evoked vibrations into electric signals, occurring in the stereocilia bundle of hair cells. The bundle is organized in a staircase pattern formed by rows of packed stereocilia. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c0f0829c16de0cf89456ba92ad039
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883914

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Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

Autor: Isabelle Landrieu, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Idir Malki, Jean-Charles Lambert

Publikováno v: FEBS Journal
FEBS Journal, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩
FEBS Journal, Wiley, 2017, 284 (19), pp.3218-3229. ⟨10.1111/febs.14185⟩

International audience; Bridging integrator 1 (bin1) gene is a genetic determinant of Alzheimer's disease (AD) and has been reported to modulate Alzheimer's pathogenesis through pathway(s) involving Tau. The functional impact of Tau/BIN1 interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe112535792d7f053c980ddc7146484
https://hal.science/hal-01620146

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Molecular optimization of rabies virus glycoprotein expression in Pichia pastoris

Autor: Brigitte Gasser, Héla Kallel, Rebecca Göngrich, Aicha Eya Belhaj, Safa Ben Azoun

Publikováno v: Microbial Biotechnology
Microbial Biotechnology, Wiley, 2016, 9 (3), pp.355-368. ⟨10.1111/1751-7915.12350⟩

International audience; In this work, different approaches were investigated to enhance the expression rabies virus glycoprotein (RABV-G) in the yeast Pichia pastoris; this membrane protein is responsible for the synthesis of rabies neutralizing anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6361eca8e76407ac9a4c11daa789638
https://hal-riip.archives-ouvertes.fr/pasteur-02012033

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Rotavirus NSP2 interferes with the core lattice protein VP2 in initiation of minus-strand synthesis

Autor: M. Alejandra Tortorici, Zenobia F. Taraporewala, John T. Patton, Patrice Vende

Publikováno v: Virology
Virology, Elsevier, 2003, 313 (1), pp.261-273. ⟨10.1016/S0042-6822(03)00302-7⟩

International audience; The rotavirus nonstructural protein NSP2 self-assembles into stable octameric structures that possess nonspecific affinity for single-stranded (ss)RNA and RNA-RNA helix-destabilizing and NTPase activities. Furthermore, NSP2 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a703cd3c85478366e0eaa8f4513243
https://doi.org/10.1016/s0042-6822(03)00302-7

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Uptake of host cell transforming growth factor-ß by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion

Autor: Waghabi, Mariana, Keramidas, Michelle, Bailly, Sabine, Degrave, Wim, Mendonça-Lima, Leila, Soeiro, Maria De Nazaré, Meirelles, Maria De Nazareth, Paciornik, Sidnei, Araújo-Jorge, Tania, Feige, Jean-Jacques

Publikováno v: American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2005, 167 (4), pp.993-1003. ⟨10.1016/s0002-9440(10)61189-3⟩
American Journal of Pathology, 2005, 167 (4), pp.993-1003. ⟨10.1016/s0002-9440(10)61189-3⟩

11 pages; International audience; Transforming growth factor-β (TGF-β) is a cytokine that plays various functions in the control of Trypanosoma cruzi infectivity and in the progression of Chagas disease. When we immunostained Trypanosoma cruzi-infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::339458e7761ed6b697e131df8c7dfe2e
https://www.hal.inserm.fr/inserm-00207611

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Uptake of host cell transforming growth factor-ß by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion

Autor: Waghabi, Mariana, Keramidas, Michelle, Bailly, Sabine, Degrave, Wim, Mendonça-Lima, Leila, Soeiro, Maria de Nazaré, Meirelles, Maria de Nazareth, Paciornik, Sidnei, Araújo-Jorge, Tania, Feige, Jean-Jacques

Publikováno v: American Journal of Pathology
American Journal of Pathology, 2005, 167 (4), pp.993-1003. ⟨10.1016/s0002-9440(10)61189-3⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::339458e7761ed6b697e131df8c7dfe2e
https://doi.org/10.1016/s0002-9440(10)61189-3

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Biochemical characterization and NMR studies of the nucleotide-binding domain 1 of multidrug-resistance-associated protein 1: evidence for interaction between ATP and Trp653

Autor: Odile Ramaen, Sandrine Masscheleyn, Marine Oberkampf, Olivier Pamlard, Francis Duffieux, Véronique Stoven, Eric Jacquet, Jean-Yves Lallemand

Publikováno v: Biochemical Journal
Biochemical Journal, 2003, 376 (3), pp.749-756. ⟨10.1042/BJ20030998⟩
Biochemical Journal, Portland Press, 2003, 376 (3), pp.749-756. ⟨10.1042/BJ20030998⟩

International audience; Multidrug-resistance-associated protein 1 (MRP1/ABCC1) is a human ATP-binding cassette transporter that confers cell resistance to antitumour drugs. Its NBDs (nucleotide-binding domains) bind/hydrolyse ATP, a key step in the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58d130a595979694c10118f5f1cb7f3
https://pubmed.ncbi.nlm.nih.gov/12954082

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