Výsledky vyhledávání - "MESH: Receptors, sigma"

Intracellular σ 1 receptor modulates phospholipase C and protein kinase C activities in the brainstem

Autor: E. E. Baulieu, François P. Monnet, Marie-Pierre Morin-Surun, T. Collin, Monique Denavit-Saubié

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1999, 96 (14), pp.8196-9

Most physiological effects of σ 1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the σ 1 receptor has allowed the identification of an intracellular protein anch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b277f6c4d43003a6b9d422c97065669f
https://doi.org/10.1073/pnas.96.14.8196

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Voltage-gated ion channels, new targets in anti-cancer research

Autor: Vandier Christophe, Besson Pierre, Ouadid-Ahidouch Halima, Ahidouch Ahmed, Soriani Olivier, Le Guennec Jean-Yves

Publikováno v: Recent Pat Anticancer Drug Discov
Recent Pat Anticancer Drug Discov, 2007, 2 (3), pp.189-202
Recent Patents Anticancer Drug Discov
Recent Patents Anticancer Drug Discov, 2007, 2 (3), pp.189-202

International audience; Cancer is one of the leading causes of mortality in the world. This is a complex disease involving many steps with proper signalling pathways. Early detection and treatment of cancers have increased survival and improved clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7d47653b39b23e005cacb3a9fda74e
https://www.hal.inserm.fr/inserm-00662369

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Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons

Autor: M. P. Morin-Surun, François P. Monnet, Laurent Combettes, J. Leger

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2003, 307 (2), pp.705-12. ⟨10.1124/jpet.103.053447⟩

International audience; Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88ccb990423fc4ac4a777fb35c5fdaa
https://hal.archives-ouvertes.fr/hal-00374393

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Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor

Autor: Marc Poirot, Sylvie Daunes, Jean-Charles Faye, Wayne D. Bowen, Berthold J Vilner, Blandine Kedjouar, Alain Klaebe

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, 1999, 58, pp.1927-39
Biochemical Pharmacology, Elsevier, 1999, 58, pp.1927-39

1-Benzyl-4-(N-2-pyrrolidinylethoxy)benzene (PBPE) is a cytotoxic derivative of the antitumoral drug tamoxifen. PBPE binds with high-affinity and specificity to the microsomal antiestrogen-binding site (AEBS). PBPE, as well as some other high-affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87edff330fa8a49b4bf7e6243c2d7a
https://www.hal.inserm.fr/inserm-00090780

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