Does Somatostatin Have a Role in the Regulation of Cortisol Secretion in Primary Pigmented Nodular Adrenocortical Disease (PPNAD)? A Clinical and in Vitro Investigation

Autor: Leo J. Hofland, Meg Keil, Constantine A. Stratakis, M Nesterova, Paraskevi Xekouki, Dimitrios Avgeropoulos, Hervé Lefebvre, Rabia Cherqaoui, Ninet Sinaii, Zakariae Bram, Estelle Louiset, Christoforos Giatzakis

Publikováno v: Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2014, 99 (5), pp.E891-E901. ⟨10.1210/jc.2013-2657⟩
Journal of Clinical Endocrinology and Metabolism, 99(5), E891-E901. Endocrine Society

Context: Somatostatin (SST) receptors (SSTRs) are expressed in a number of tissues, including the adrenal cortex, but their role in cortisol secretion has not been well characterized. Objectives: The objective of the study was to investigate the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80b166816723162ec9c019985da996a
https://pure.eur.nl/en/publications/c6c4d9d3-887a-4f52-bdcc-15b074372539

Identification of an Upstream Promoter of the Human Somatostatin Receptor, hSSTR2, Which Is Controlled by Epigenetic Modifications

Autor: Jean-José Maoret, Naïma Hanoun, Anny Souque, Pierre Cordelier, Frédéric Lopez, Jérôme Torrisani, Louis Buscail, Christiane Susini, Henrik Laurell

Publikováno v: Endocrinology
Endocrinology, 2008, 149 (6), pp.3137-47. ⟨10.1210/en.2007-1525⟩

International audience; Somatostatin is a neuropeptide that inhibits exocrine and endocrine secretions of several hormones and negatively regulates cell proliferation. These events are mediated through somatostatin engagement on one of five G protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a41425cbf8bfccfc321fa5cc03601a
https://doi.org/10.1210/en.2007-1525

Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures

Autor: Mohamed, Amira, Blanchard, Marie-Pierre, Albertelli, Manuela, Barbieri, Federica, Brue, Thierry, Niccoli, Patricia, Delpero, Jean-Robert, Monges, Genevieve, Garcia, Stephane, Ferone, Diego, Florio, Tullio, Enjalbert, Alain, Moutardier, Vincent, Schonbrunn, Agnes, Gerard, Corinne, Barlier, Anne, Saveanu, Alexandru

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2014, 21 (5), pp.691-704. ⟨10.1530/ERC-14-0086⟩
Endocrine-Related Cancer, 2014, 21 (5), pp.691-704. ⟨10.1530/ERC-14-0086⟩

International audience; Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) raise difficult therapeutic problems despite the emergence of targeted therapies. Somatostatin analogs (SSA) remain pivotal therapeutic drugs. However, the tachyphylaxis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::119714f577583fa2a93af99003d85651
https://pubmed.ncbi.nlm.nih.gov/25012983

Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer

Autor: Laurent Dumartin, Martin Hagedorn, Marie Bernadette Delisle, Sophie Le Guellec, Andreas Bikfalvi, Corinne Bousquet, Séverine Laval, Philippe Rochaix, Andrew V. Schally, Christiane Susini, Stéphane Pyronnet, Hanane Laklai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (42), pp.17769-74. ⟨10.1073/pnas.0908674106⟩
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (42), pp.17769-74. ⟨10.1073/pnas.0908674106⟩

International audience; The somatostatin receptor subtype 2 (sst2) behaves as a tumor suppressor when expressed and stimulated by its ligand somatostatin in pancreatic cancer. We reveal a mechanism underlying oncosuppressive action of sst2, whereby t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ad9fac560f3de0c2c0ab1a9946753
https://europepmc.org/articles/PMC2764925/

[A cause of intracerebral calcifications that should be known: pseudohypoparathyroidism Ib]

Autor: P, Faissolle, K, Wagner-Mahler, J-C, Mas, M, Moreigne, A, Khalfi, V, Léonetti, M, Silvy, A, Barlier, H, Giudicelli

Publikováno v: Archives de Pédiatrie
Archives de Pédiatrie, 2008, 15 (9), pp.1433-6. ⟨10.1016/j.arcped.2008.06.016⟩
Archives de Pédiatrie, Elsevier, 2008, 15 (9), pp.1433-6. ⟨10.1016/j.arcped.2008.06.016⟩

International audience; In children, pseudohypoparathyroidism (PHP) is a rare but classical cause of basal ganglia calcifications. It is caused by resistance to parathormone (PTH). Hypocalcemia, which may be symptomatic, is its main feature. We repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0cb40b1f5cf461fba4171842b06c2270
https://hal.science/hal-00398609