mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Autor: Martin, Pierre-Yves, Doly, Stéphane, Hamieh, Al Mahdy, Chapuy, Eric, Canale, Vittorio, Drop, Marcin, Chaumont-Dubel, Séverine, Bantreil, Xavier, Lamaty, Frédéric, Bojarski, Andrzej, Zajdel, Pawel, Eschalier, Alain, Marin, Philippe, COURTEIX, Christine

Publikováno v: Progress in Neurobiology
Progress in Neurobiology, Elsevier, 2020, 193, pp.101846. ⟨10.1016/j.pneurobio.2020.101846⟩
Progress in Neurobiology, 2020, 193, pp.101846. ⟨10.1016/j.pneurobio.2020.101846⟩

International audience; Chronic neuropathic pain is a highly disabling syndrome that is poorly controlled by currently available analgesics. Here, we show that painful symptoms and associated cognitive deficits induced by spinal nerve ligation in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8aef17b38cdcef4604d7c319d906c1cb
https://hal.uca.fr/hal-02906397/document

Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor

Autor: Aline Desmyter, Horst Vogel, Lamia Mebarki, Takashi Tomizaki, Ruud Hovius, Romain Wyss, Sonja Minniberger, Xiao-Dan Li, Christophe Moreau, Lucie Peclinovska, Ghérici Hassaine, Cédric Deluz, Hugues Nury, Luigino Grasso, Henning Stahlberg

Publikováno v: Methods in Molecular Biology
Methods in Molecular Biology, Humana Press/Springer Imprint, 2018, pp.139-168. ⟨10.1007/978-1-4939-7151-0_8⟩
Methods in Molecular Biology, 2018, pp.139-168. ⟨10.1007/978-1-4939-7151-0_8⟩
Methods in Molecular Biology ISBN: 9781493971497
Methods in Molecular Biology-Membrane Protein Structure and Function Characterization
Methods in Molecular Biology, Membrane Protein Structure and Function Characterization

International audience; There is growing interest in the use of mammalian protein expression systems, and in the use of antibody-derived chaperones, for structural studies. Here, we describe protocols ranging from the production of recombinant membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97109ac8dfda1b9855a018b3376074a
https://hal.archives-ouvertes.fr/hal-01802945

Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse

Autor: Thomas Freret, Véronique Lelong-Boulouard, Pierre Lecouflet, François Dauphin, Katia Hamidouche, Michel Boulouard

Publikováno v: Psychopharmacology
Psychopharmacology, Springer Verlag, 2017, 234 (15), pp.2365-2374. ⟨10.1007/s00213-017-4664-z⟩

It is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7807a009be755f6ab4c1595b14028578
https://hal-normandie-univ.archives-ouvertes.fr/hal-02135214

Time-dependent impact of glutamatergic modulators on the promnesiant effect of 5-HT 6 R blockade on mice recognition memory

Autor: Asselot, Rachel, Simon-O'Brien, Emmanuelle, Lebourgeois, Sophie, Nee, Gérald, Delaunay, Virgile, Duchatelle, Pascal, Bouet, Valentine, DAUPHIN, François, Simon-O’Brien, Emmanuelle

Publikováno v: Pharmacological Research
Pharmacological Research, Elsevier, 2017, 118, pp.111-118. ⟨10.1016/j.phrs.2016.06.009⟩

Selective antagonists at serotonin 5-HT 6 receptors (5-HT 6 R) improve memory performance in rodents and are currently under clinical investigations. If blockade of 5-HT 6 R is known to increase glutamate release, only two studies have so far demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a47961f959fed30162b1e1565bbd315
https://hal-normandie-univ.archives-ouvertes.fr/hal-02135223

5-HT3Receptors Mediate Serotonergic Fast Synaptic Excitation of Neocortical Vasoactive Intestinal Peptide/Cholecystokinin Interneurons

Autor: Bertrand Lambolez, Edith Hamel, Bruno Cauli, Elisa L. Hill, Jean Rossier, Isabelle Ferezou

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2002, 22 (17), pp.7389-97. ⟨10.1523/JNEUROSCI.22-17-07389.2002⟩

International audience; Neocortical neurons expressing the serotonin 5-HT3 receptor (5-HT3R) were characterized in rat acute slices by using patch-clamp recordings combined with single-cell RT-PCR and histochemical labeling. The 5-HT3A receptor subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4cd8816f19f79785e92bd87a1d35aa
https://doi.org/10.1523/jneurosci.22-17-07389.2002