Zobrazeno 1 - 10 of 51 pro vyhledávání: '"MESH: Receptors, IgG"'
1
The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors
Autor: Bianca Balbino, Julien Stackowicz, Kari C. Nadeau, Pauline Herviou, Ophélie Godon, Sébastien Brûlé, Delphine Sterlin, Andrew J. Murphy, Vera Voronina, Bruno Iannascoli, Odile Richard-Le Goff, Gaël A. Millot, Macdonald Lynn, Laurent L. Reber, Harris Faith, Pierre Bruhns
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
J Clin Invest
International audience; Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of Omalizumab is associated with reported side effects, ranging from local skin inflammatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c06554f4a34ad7e3a43c7c44772130
https://doi.org/10.1172/jci129697
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2
From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement
Autor: Coënon, Loïs, Villalba, Martin
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2022, 13, pp.913215. ⟨10.3389/fimmu.2022.913215⟩
International audience; Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3b85a834634f937684ad7eebcdc0a5
https://doi.org/10.3389/fimmu.2022.913215
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3
TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
Autor: Izabela A. Rodenhuis-Zybert, Vinit Upasani, Bram M. ter Ellen, Mariana Ruiz-Silva, Rithy Choeung, Jill Moser, Mindaugas Pauzuolis, Denis R. St. Laurent, Tineke Cantaert, Philippe Dussart, José Alberto Aguilar-Briseño, Sothy Heng, Jolanda M. Smit
Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3177. ⟨10.1038/s41467-020-16849-7⟩
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, 11(1):3177. Nature Publishing Group
Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus (DENV) infection, but the mechanisms underlying the exacerbated inflammation during DENV pathogenesis are unclear. Here, we demonstrate that TLR2, together with it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208ffd5bdf01936c1e26cb9d9b748d7d
https://hal-riip.archives-ouvertes.fr/pasteur-03221719
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4
Fcγ receptor expression on splenic macrophages in adult immune thrombocytopenia
Autor: Bernard Bonnotte, Annemieke G. Laarhoven, Kim Santegoets, Philippe Saas, Maxime Samson, Gestur Vidarsson, Sylvain Audia, Olivier Facy, Timothy R D J Radstake, Pablo Ortega-Deballon, Nona Janikashvili
Publikováno v: Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2017, 188 (2), pp.275-282. ⟨10.1111/cei.12935⟩
Clinical and Experimental Immunology, 188, 275-282
Clinical and Experimental Immunology, 188(2), 275. Wiley-Blackwell
Clinical and Experimental Immunology, 188, 2, pp. 275-282
Clinical and experimental immunology, 188(2), 275-282. Wiley-Blackwell
Clinical and Experimental Immunology, Wiley, 2017, 188 (2), pp.275-282. 〈http://onlinelibrary.wiley.com/doi/10.1111/cei.12935/abstract;jsessionid=FBA5B398503A03620104AAB3C880D684.f02t03?systemMessage=Wiley+Online+Library+%27Journal+Subscribe+%2F+Renew%27+page+will+be+down+on+Wednesday+05th+July+starting+at+08.00+EDT+%2F+13.00+BST+%2F+17.30+IST+for+up+to+75+minutes+due+to+essential+maintenance.〉. 〈10.1111/cei.12935〉
Summary Splenic macrophages play a key role in immune thrombocytopenia (ITP) pathogenesis by clearing opsonized platelets. Fcγ receptors (FcγR) participate in this phenomenon, but their expression on splenic macrophages and their modulation by trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcb58ff87b7880a8fbd365c5a5237a6
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01556448
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5
Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis
Autor: Philipp Starkl, Riccardo Sibilano, Laurent L. Reber, Hajime Karasuyama, Bianca Balbino, Stephen J. Galli, Pierre Bruhns, Thomas Marichal, Mindy Tsai, Nicolas Gaudenzio
Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2017, 139 (2), pp.584-596.e10. ⟨10.1016/j.jaci.2016.05.047⟩
Journal of Allergy and Clinical Immunology, 2017, 139 (2), pp.584-596.e10. ⟨10.1016/j.jaci.2016.05.047⟩
Background Conflicting results have been obtained regarding the roles of Fc receptors and effector cells in models of active systemic anaphylaxis (ASA). In part, this might reflect the choice of adjuvant used during sensitization because various adju
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa3bc6fe0560e9470ac64a04dde18b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02510918
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6
Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy
Autor: Pierre Bruhns, Jean-Luc Teillaud
Publikováno v: Cancer Cell
Cancer Cell, 2016, 29 (6), pp.771-773. ⟨10.1016/j.ccell.2016.05.009⟩
Cancer Cell, Elsevier, 2016, 29 (6), pp.771-773. ⟨10.1016/j.ccell.2016.05.009⟩
While engagement of the inhibitory Fcγ-Receptor (FcγR) IIB is an absolute requirement for in vivo antitumor activity of agonistic mouse anti-CD40 monoclonal antibodies (mAbs), a similar requirement for human mAbs has been disputed. By using a mouse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ae318ac64be8693a12fc90783c8e23
https://doi.org/10.1016/j.ccell.2016.05.009
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7
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions
Autor: Bianca Balbino, George Delidakis, Tae Hyun Kang, Makiko Watanabe, Kendra Triplett, Anja Lux, Navin Varadarajan, Odile Richard-Le Goff, Oana I. Lungu, Pierre Bruhns, George Georgiou, Corrine Alford, Gabrielle Romain, Margaret A. Lindorfer, Wissam Charab, Falk Nimmerjahn, Yan Jessie Zhang, Hidetaka Tanno, Wupeng Yan, Nicholas M. Marshall, Moses Donkor, Chang-Han Lee, Jiwon Lee, Ronald P. Taylor, Biliana Todorova
Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2017, 18 (8), pp.889-898. ⟨10.1038/ni.3770⟩
Nature Immunology, 2017, 18 (8), pp.889-898. ⟨10.1038/ni.3770⟩
International audience; Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the complement com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d0740466da17325dc05af13c9b0b13
https://hal-pasteur.archives-ouvertes.fr/pasteur-02510289
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8
Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis
Autor: Gilles Hayem, Erwan Boedec, Tarek Boussetta, Renato C. Monteiro, Jean-Michel Goujon, Pierre Launay, Pierre Bruhns, Sanae Ben Mkaddem, Marc Benhamou, Jamel El Benna, Friederike Jönsson, Elisabetta Rossato
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2014, 124 (9), pp.3945-3959. ⟨10.1172/JCI74572⟩
Journal of Clinical Investigation, 2014, 124 (9), pp.3945-3959. ⟨10.1172/JCI74572⟩
International audience; Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73a8e812d16c6dc34dddbfc4c460990
https://doi.org/10.1172/jci74572
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9
The function of Fcγ receptors in dendritic cells and macrophages
Autor: Hamida Hammad, Pierre Bruhns, Martin Guilliams, Bart N. Lambrecht, Yvan Saeys
Publikováno v: Nature Reviews Immunology
Nature Reviews Immunology, Nature Publishing Group, 2014, 14 (2), pp.94-108. ⟨10.1038/nri3582⟩
Nature Reviews Immunology, 14(2), 94-108. Nature Publishing Group
Nature Reviews Immunology, 2014, 14 (2), pp.94-108. ⟨10.1038/nri3582⟩
An Erratum to this article was published on 07 April 2014; International audience; Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9879f5f0879ac0e0a3299e116ba0e3
https://doi.org/10.1038/nri3582
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10
Neutrophils mediate antibody-induced antitumor effects in mice
Autor: James P. Di Santo, Pierre Bruhns, Laurence Fiette, Friederike Jönsson, David A. Mancardi, Clifford A. Lowell, Bruno Iannascoli, Marcello Albanesi
Publikováno v: Blood
Blood, American Society of Hematology, 2013, 122 (18), pp.3160-3164. ⟨10.1182/blood-2013-04-497446⟩
Blood, 2013, 122 (18), pp.3160-3164. ⟨10.1182/blood-2013-04-497446⟩
International audience; Tumor engraftment followed by monoclonal antibody (mAb) therapy targeting tumor antigens represents a gold standard for assessing the efficiency of mAbs to eliminate tumor cells. Mouse models have demonstrated that receptors f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e8e94921f34686b498c42eb7e4ce7b
https://doi.org/10.1182/blood-2013-04-497446
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