Zobrazeno 1 - 10 of 91 pro vyhledávání: '"MESH: Receptors, Cytoplasmic and Nuclear"'
1
IDPs and their complexes in GPCR and nuclear receptor signaling
Autor: Pau Bernadó, Jean-Louis Banères, William Bourguet, Myriam Guillien, Assia Mouhand, Albane le Maire, Nathalie Sibille
Publikováno v: Progress in Molecular Biology and Translational Science.Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B.Edited by Vladimir N. Uversky.Volume 174
Progress in Molecular Biology and Translational Science. Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B. Edited by Vladimir N. Uversky. Volume 174, pp.105-155, 2020, ⟨10.1016/bs.pmbts.2020.05.001⟩
Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B
Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, 174, Elsevier, pp.105-155, 2020, Progress in Molecular Biology and Translational Science, ⟨10.1016/bs.pmbts.2020.05.001⟩
Progress in Molecular Biology and Translational Science
Progress in Molecular Biology and Translational Science, 2020, Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, 174, pp.105-155. ⟨10.1016/bs.pmbts.2020.05.001⟩
Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B ISBN: 9780128226155
International audience; G protein-coupled receptors (GPCRs) and Nuclear Receptors (NRs) are two signaling machineries that are involved in major physiological processes and, as a consequence, in a substantial number of diseases. Therefore, they actua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a8c2d1f80324f354000c2cb9c4ed42
https://hal.archives-ouvertes.fr/hal-03047213
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2
Endocrine disrupting potential of replacement flame retardants – Review of current knowledge for nuclear receptors associated with reproductive outcomes
Autor: Johanna Barthelemy-Berneron, Lola Bajard, Vicente Mustieles, Ludek Blaha, Stéphane Jomini, Mariana F. Fernández, Chander K. Negi, Lisa Emily Melymuk
Publikováno v: Environment International
Environment International, Elsevier, 2021, 153, pp.106550. ⟨10.1016/j.envint.2021.106550⟩
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Environment International, Vol 153, Iss, Pp 106550-(2021)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Environment International, 2021, 153, pp.106550. ⟨10.1016/j.envint.2021.106550⟩
The research was supported by funding from the European Unions ' Horizon 2020 Research and Innovation Programme under grant agreements No 733032 (HBM4EU) , No. 859891 (PRORISK) , and No. 857560 (CETOCOEN EXCELLENCE Teaming 2 project) . The RECETOX Re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0903a37dbeabfe49491576c402f1492
https://doi.org/10.1016/j.envint.2021.106550
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3
Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability
Autor: Alexandre Evrard, Litaty Mbatchi, Jean-Paul Brouillet
Publikováno v: Pharmacogenomics
Pharmacogenomics, Future Medicine, 2018, 19 (1), pp.61-77. ⟨10.2217/pgs-2017-0121⟩
International audience; NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors. Upon activation by various xenobiotics, including marketed drugs, they regulate the transcription level of major drug-metabolizing enzymes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12615a7a0408f756b9e836fbcef9e3e7
https://hal.umontpellier.fr/hal-02290151
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4
Structure of a Truncation Mutant of the Nuclear Export Factor CRM1 Provides Insights into the Auto-Inhibitory Role of Its C-Terminal Helix
Autor: Christoph W. Müller, Guy Schoehn, Florent Bernaudat, Karla Langer, Mizar F. Oliva, Cyril Dian, Carlo Petosa, Maarten Fornerod
Publikováno v: Structure (London, England : 1993)
Structure (London, England : 1993), 2013, 21 (8), pp.1338-49
Structure, 21(8), 1338-1349. Cell Press
International audience; Chromosome region maintenance 1/exportin1/Xpo1 (CRM1) associates with the GTPase Ran to mediate the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 consists of helical hairpin HEAT repeats a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89002a9d66aabd3a48c7429910994158
https://doi.org/10.1016/j.str.2013.06.003
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6
L’association fait le poison
Autor: Delfosse, Vanessa, Balaguer, Patrick, Bourguet, William
Publikováno v: médecine/sciences
médecine/sciences, 2016, 32 (4), pp.326-328. ⟨10.1051/medsci/20163204005⟩
International audience
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::c0db6c2b9071c2f5bf002dd6bc67448f
https://hal.umontpellier.fr/hal-02295655
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7
Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver
Autor: Anne Tailleux, Barbara Gross, Fanny Lalloyer, Emmanuelle Vallez, Sophie Lestavel, Thomas Åskov Pedersen, Bart Staels, Saïd Yous, Catherine Fievet, Jan-Ake Gustafsson, Susanne Mandrup
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2009, 29 (10), pp.1488-95. ⟨10.1161/ATVBAHA.109.189506⟩
Lalloyer, F, Pedersen, T Å, Gross, B, Lestavel, S, Yous, S, Vallez, E, Gustafsson, J-Å, Mandrup, S, Fiévet, C, Staels, B & Tailleux, A 2009, ' Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 10, pp. 1488-1495 . https://doi.org/10.1161/ATVBAHA.109.189506
Objective— Bexarotene (Targretin) is a clinically used antitumoral agent which exerts its action through binding to and activation of the retinoid-X-receptor (RXR). The most frequent side-effect of bexarotene administration is an increase in plasma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2e41fa53f67f77e28bf39bfb300cb5
https://doi.org/10.1161/atvbaha.109.189506
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8
Rev-erbα2 mRNA Encodes a Stable Protein with a Potential Role in Circadian Clock Regulation
Autor: Vincent Laudet, Gérard Benoit, Ingrid Masse, Bart Staels, Juliette Rambaud, Gérard Triqueneaux
Publikováno v: Mol Endocrinol
Mol Endocrinol, 2009, 23 (5), pp.630-9. ⟨10.1210/me.2008-0395⟩
International audience; Circadian rhythms are observed in nearly all aspects of physiology and behavior. In mammals, such biological rhythms are supported by a complex network of self-sustained transcriptional loops and posttranslational modification
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67a1c7041af11c47b45658fb3db8a5d
https://doi.org/10.1210/me.2008-0395
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9
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
Autor: Alain Sarasin, Melissa Gava Armelini, Gustavo P. Amarante-Mendes, Carlos Frederico Martins Menck, Vanessa Chiganças, Jacqueline F. Jacysyn, Keronninn M. Lima-Bessa
Publikováno v: DNA Repair
DNA Repair, Elsevier, 2008, 7 (2), pp.303-12. ⟨10.1016/j.dnarep.2007.11.003⟩
Ultraviolet (UV) light generates two major DNA lesions: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific participation of these two lesions in the deleterious effects of UV is a longstandin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58d0c9fba45f70457a6d02c33622459
https://doi.org/10.1016/j.dnarep.2007.11.003
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10
Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23- and 6,23-Alkyl-Substituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5
Autor: Johan Auwerx, Roberto Pellicciari, Gianluca Giorgi, Kristina Schoonjans, Hiroyuki Sato, Bahman M. Sadeghpour, Gabriele Costantino, Antimo Gioiello, Antonio Macchiarulo
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (18), pp.4265-8. ⟨10.1021/jm070633p⟩
23-Alkyl-substituted and 6,23-alkyl-disubstituted derivatives of chenodeoxycholic acid are identified as potent and selective agonists of TGR5, a G-protein coupled receptor for bile acids (BAs). In particular, we show that methylation at the C-23(S)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3cfa699a9b29607cfb7429c74274dd
https://doi.org/10.1021/jm070633p
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